DOI: 10.1126/science.224.4656.1443. Acetolactate Synthase Is the Site of Action of Two Sulfonylurea Herbicides in Higher Plants

Acetolactate Synthase Is the Site of Action of Two Sulfonylurea Herbicides in Higher Plants

10.1126/science.224.4656.1443

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Biochemical and genetic studies of a tobacco mutant resistant to the herbicides chlorsulfuron and sulfometuron methyl have demonstrated that these sulfonylurea herbicides inhibit acetolactate synthase, the first enzyme specific to the branched chain amino acid biosynthetic pathway. Resistance of this mutant is accomplished by production of a form of the enzyme that is insensitive to inhibition by the two herbicides.

Bibliography

Chaleff, R. S., & Mauvais, C. J. (1984). Acetolactate Synthase Is the Site of Action of Two Sulfonylurea Herbicides in Higher Plants. Science, 224(4656), 1443â1445.

Authors 2

R. S. Chaleff (first)
C. J. Mauvais (additional)

References 13 Referenced 347

ASHTON, F.M., HERBICIDES PHYSL BIO 1: 219 (1976). / HERBICIDES PHYSL BIO (1976)
CHALEFF R.S. GENETICS HIGHER PLAN (1981).
CHALEFF, R.S., DIRECT SELECTION INVITRO FOR HERBICIDE-RESISTANT MUTANTS OF NICOTIANA-TABACUM, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 75: 5104 (1978). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1978)
10.1126/science.219.4585.676
10.1126/science.223.4641.1148
10.1126/science.221.4608.370
FALCO S.C. unpublished data.
JAWORSKI, E.G., MODE OF ACTION OF N-PHOSPHONOMETHYLGLYCINE - INHIBITION OF AROMATIC AMINO-ACID BIOSYNTHESIS, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 20: 1195 (1972). (10.1021/jf60184a057) / JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (1972)
LAROSSA R.A. unpublished data.
MULLER, A.J., GENETIC-ANALYSIS OF NITRATE REDUCTASE-DEFICIENT TOBACCO PLANTS REGENERATED FROM MUTANT-CELLS - EVIDENCE FOR DUPLICATE STRUCTURAL GENES, MOLECULAR & GENERAL GENETICS 192: 275 (1983). (10.1007/BF00327678) / MOLECULAR & GENERAL GENETICS (1983)
Ray, T. B., Plant Physiology 75: 827 (1984). (10.1104/pp.75.3.827) / Plant Physiology (1984)
WESTERFELD, W.W., A COLORIMETRIC DETERMINATION OF BLOOD ACETOIN, JOURNAL OF BIOLOGICAL CHEMISTRY 161: 495 (1945). (10.1016/S0021-9258(17)41484-0) / JOURNAL OF BIOLOGICAL CHEMISTRY (1945)
ZELITCH, I, ALTERED GLYCINE DECARBOXYLATION INHIBITION IN ISONICOTINIC-ACID HYDRAZIDE-RESISTANT MUTANT CALLUS LINES AND IN REGENERATED PLANTS AND SEED PROGENY, PLANT PHYSIOLOGY 69: 198 (1982). (10.1104/pp.69.1.198) / PLANT PHYSIOLOGY (1982)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 3:41 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 4:29 a.m.)
Indexed	4 weeks, 2 days ago (Aug. 5, 2025, 8:23 a.m.)
Issued	41 years, 2 months ago (June 29, 1984)
Published	41 years, 2 months ago (June 29, 1984)
Published Print	41 years, 2 months ago (June 29, 1984)

Funders 0

None

BibTeX

@article{Chaleff_1984, title={Acetolactate Synthase Is the Site of Action of Two Sulfonylurea Herbicides in Higher Plants}, volume={224}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.224.4656.1443}, DOI={10.1126/science.224.4656.1443}, number={4656}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Chaleff, R. S. and Mauvais, C. J.}, year={1984}, month=jun, pages={1443–1445} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        5
      ]
    ],
    "date-time": "2025-08-05T12:23:14Z",
    "timestamp": 1754396594448
  },
  "reference-count": 13,
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "issue": "4656",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1984,
        6,
        29
      ]
    ]
  },
  "abstract": "<jats:p>Biochemical and genetic studies of a tobacco mutant resistant to the herbicides chlorsulfuron and sulfometuron methyl have demonstrated that these sulfonylurea herbicides inhibit acetolactate synthase, the first enzyme specific to the branched chain amino acid biosynthetic pathway. Resistance of this mutant is accomplished by production of a form of the enzyme that is insensitive to inhibition by the two herbicides.</jats:p>",
  "DOI": "10.1126/science.224.4656.1443",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        10,
        5
      ]
    ],
    "date-time": "2006-10-05T19:41:59Z",
    "timestamp": 1160077319000
  },
  "page": "1443-1445",
  "source": "Crossref",
  "is-referenced-by-count": 347,
  "title": "Acetolactate Synthase Is the Site of Action of Two Sulfonylurea Herbicides in Higher Plants",
  "prefix": "10.1126",
  "volume": "224",
  "author": [
    {
      "given": "R. S.",
      "family": "Chaleff",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Central Research and Development, Experimental Station, E. I. du Pont de Nemours and Company, Wilimington, Delaware 19898"
        }
      ]
    },
    {
      "given": "C. J.",
      "family": "Mauvais",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Central Research and Development, Experimental Station, E. I. du Pont de Nemours and Company, Wilimington, Delaware 19898"
        }
      ]
    }
  ],
  "member": "221",
  "reference": [
    {
      "key": "e_1_2_1_1_1",
      "first-page": "219",
      "volume": "1",
      "year": "1976",
      "unstructured": "ASHTON, F.M., HERBICIDES PHYSL BIO 1: 219 (1976).",
      "journal-title": "HERBICIDES PHYSL BIO"
    },
    {
      "key": "e_1_2_1_2_1",
      "unstructured": "CHALEFF R.S. GENETICS HIGHER PLAN (1981)."
    },
    {
      "key": "e_1_2_1_3_1",
      "first-page": "5104",
      "volume": "75",
      "year": "1978",
      "unstructured": "CHALEFF, R.S., DIRECT SELECTION INVITRO FOR HERBICIDE-RESISTANT MUTANTS OF NICOTIANA-TABACUM, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 75: 5104 (1978).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_4_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.219.4585.676"
    },
    {
      "key": "e_1_2_1_5_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.223.4641.1148"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.221.4608.370"
    },
    {
      "key": "e_1_2_1_7_1",
      "unstructured": "FALCO S.C. unpublished data."
    },
    {
      "key": "e_1_2_1_8_1",
      "doi-asserted-by": "crossref",
      "first-page": "1195",
      "DOI": "10.1021/jf60184a057",
      "volume": "20",
      "year": "1972",
      "unstructured": "JAWORSKI, E.G., MODE OF ACTION OF N-PHOSPHONOMETHYLGLYCINE - INHIBITION OF AROMATIC AMINO-ACID BIOSYNTHESIS, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 20: 1195 (1972).",
      "journal-title": "JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY"
    },
    {
      "key": "e_1_2_1_9_1",
      "unstructured": "LAROSSA R.A. unpublished data."
    },
    {
      "key": "e_1_2_1_10_1",
      "doi-asserted-by": "crossref",
      "first-page": "275",
      "DOI": "10.1007/BF00327678",
      "volume": "192",
      "year": "1983",
      "unstructured": "MULLER, A.J., GENETIC-ANALYSIS OF NITRATE REDUCTASE-DEFICIENT TOBACCO PLANTS REGENERATED FROM MUTANT-CELLS - EVIDENCE FOR DUPLICATE STRUCTURAL GENES, MOLECULAR & GENERAL GENETICS 192: 275 (1983).",
      "journal-title": "MOLECULAR & GENERAL GENETICS"
    },
    {
      "key": "e_1_2_1_11_1",
      "doi-asserted-by": "crossref",
      "first-page": "827",
      "DOI": "10.1104/pp.75.3.827",
      "volume": "75",
      "year": "1984",
      "unstructured": "Ray, T. B., Plant Physiology 75: 827 (1984).",
      "journal-title": "Plant Physiology"
    },
    {
      "key": "e_1_2_1_12_1",
      "doi-asserted-by": "crossref",
      "first-page": "495",
      "DOI": "10.1016/S0021-9258(17)41484-0",
      "volume": "161",
      "year": "1945",
      "unstructured": "WESTERFELD, W.W., A COLORIMETRIC DETERMINATION OF BLOOD ACETOIN, JOURNAL OF BIOLOGICAL CHEMISTRY 161: 495 (1945).",
      "journal-title": "JOURNAL OF BIOLOGICAL CHEMISTRY"
    },
    {
      "key": "e_1_2_1_13_1",
      "doi-asserted-by": "crossref",
      "first-page": "198",
      "DOI": "10.1104/pp.69.1.198",
      "volume": "69",
      "year": "1982",
      "unstructured": "ZELITCH, I, ALTERED GLYCINE DECARBOXYLATION INHIBITION IN ISONICOTINIC-ACID HYDRAZIDE-RESISTANT MUTANT CALLUS LINES AND IN REGENERATED PLANTS AND SEED PROGENY, PLANT PHYSIOLOGY 69: 198 (1982).",
      "journal-title": "PLANT PHYSIOLOGY"
    }
  ],
  "container-title": "Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.science.org/doi/pdf/10.1126/science.224.4656.1443",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        12
      ]
    ],
    "date-time": "2024-01-12T09:29:11Z",
    "timestamp": 1705051751000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.science.org/doi/10.1126/science.224.4656.1443"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1984,
        6,
        29
      ]
    ]
  },
  "references-count": 13,
  "journal-issue": {
    "issue": "4656",
    "published-print": {
      "date-parts": [
        [
          1984,
          6,
          29
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.224.4656.1443"
  ],
  "URL": "http://dx.doi.org/10.1126/science.224.4656.1443",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1984,
        6,
        29
      ]
    ]
  }
}