DOI: 10.1126/science.222.4622.419. Male Esterase 6 Catalyzes the Synthesis of a Sex Pheromone in <i>Drosophila melanogaster</i> Females

Male Esterase 6 Catalyzes the Synthesis of a Sex Pheromone in Drosophila melanogaster Females

10.1126/science.222.4622.419

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Esterase 6, a component of the seminal fluid of Drosophila melanogaster males, hydrolyzes cis -vaccenyl acetate, a lipid made only by males, to cis -vaccenyl alcohol. This reaction occurs in the female reproductive tract and is virtually complete within 6 hours after copulation. Both the alcohol and the acetate decrease the number of matings among pairs of virgin flies in which the female is treated topically with these substances. Although females tested 10 minutes after copulation elicit less courtship than virgin females, females tested 6 hours after copulation stimulate even less courtship if they received active esterase 6 in the seminal fluid of their respective mates. Either the alcohol or a derivative appears to be an antiaphrodisiac that decreases courtship elicited by inseminated females and thus reduces the probability of further mating. Thus the activity of the pheromone depends on a final reaction which occurs in the female, using both substrate and enzyme provided by the male.

Bibliography

Mane, S. D., Tompkins, L., & Richmond, R. C. (1983). Male Esterase 6 Catalyzes the Synthesis of a Sex Pheromone in Drosophila melanogaster Females. Science, 222(4622), 419â421.

Authors 3

Suresh D. Mane (first)
Laurie Tompkins (additional)
Rollin C. Richmond (additional)

References 27 Referenced 98

ANTONY, C, EVOLUTION OF BEHAVIORALLY ACTIVE HYDROCARBONS OF DROSOPHILA-MELANOGASTER IN THE COURSE OF SEXUAL-MATURATION, COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES 292: 239 (1981). / COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES (1981)
AVERHOFF, W.W., MULTIPLE PHEROMONE SYSTEM CONTROLLING MATING IN DROSOPHILA-MELANOGASTER, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 73: 591 (1976). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1976)
10.1126/science.167.3922.1262
10.1126/science.163.3873.1356
COYNE, J.A., EXTENT OF GENETIC-VARIATION AT A HIGHLY POLYMORPHIC ESTERASE LOCUS IN DROSOPHILA-PSEUDOOBSCURA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 75: 5090 (1978). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1978)
GILBERT, D.G., STUDIES OF ESTERASE-6 IN DROSOPHILA-MELANOGASTER .7. RE-MATING TIMES OF FEMALES INSEMINATED BY MALES HAVING ACTIVE OR NULL ALLELES, BEHAVIOR GENETICS 11: 195 (1981). (10.1007/BF01065458) / BEHAVIOR GENETICS (1981)
GILBERT, D.G., STUDIES OF ESTERASE-6 IN DROSOPHILA-MELANOGASTER .8. EJACULATE ESTERASE-6 AND INITIAL SPERM USE BY FEMALE DROSOPHILA-MELANOGASTER, JOURNAL OF INSECT PHYSIOLOGY 27: 641 (1981). (10.1016/0022-1910(81)90112-8) / JOURNAL OF INSECT PHYSIOLOGY (1981)
GILBERT, L.E., POSTMATING FEMALE ODOR IN HELICONIUS BUTTERFLIES - MALE-CONTRIBUTED ANTI-APHRODISIAC, SCIENCE 193: 419 (1976). (10.1126/science.935877) / SCIENCE (1976)
HALL, J.C., GENETICS OF ACETYLCHOLINESTERASE IN DROSOPHILA-MELANOGASTER, GENETICS 83: 517 (1976). (10.1093/genetics/83.3.517) / GENETICS (1976)
JALLON, J.M., 1ST CHARACTERIZATION OF APHRODISIAC SUBSTANCES IN DROSOPHILA-MELANOGASTER, COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES SERIE D 291: 717 (1980). / COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES SERIE D (1980)
JALLON, J.M., AN ANTI-APHRODISIAC PRODUCED BY DROSOPHILA-MELANOGASTER MALES AND TRANSFERRED TO FEMALES DURING COPULATION, COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES 292: 1147 (1981). / COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES (1981)
JOHNSON, F.M., U TEXAS PUBL 6615: 517 (1966). / U TEXAS PUBL (1966)
MANE, S.D., BIOCH GENET 211: 1019 (1983). / BIOCH GENET (1983)
MANNING, A, CONTROL OF SEXUAL RECEPTIVITY IN FEMALE DROSOPHILA, ANIMAL BEHAVIOUR 15: 239 (1967). (10.1016/0003-3472(67)90006-1) / ANIMAL BEHAVIOUR (1967)
OAKESHOTT, J.G., LATITUDINAL RELATIONSHIPS OF ESTERASE-6 AND PHOSPHOGLUCOMUTASE GENE-FREQUENCIES IN DROSOPHILA-MELANOGASTER, HEREDITY 47: 385 (1981). (10.1038/hdy.1981.99) / HEREDITY (1981)
RICHMOND, R.C., STUDIES OF ESTERASE 6 OF DROSOPHILA-MELANOGASTER .6. KINETICS OF TRANSFER TO FEMALES, DECAY IN FEMALES AND MALE RECOVERY, JOURNAL OF INSECT PHYSIOLOGY 27: 849 (1981). (10.1016/0022-1910(81)90086-X) / JOURNAL OF INSECT PHYSIOLOGY (1981)
10.1126/science.6767273
RODRIGUES, V, DEV NEUROBIOLOGY DRO: 361 (1980). / DEV NEUROBIOLOGY DRO (1980)
RODRIGUES, V, GENETIC-ANALYSIS OF CHEMOSENSORY PATHWAY, PROCEEDINGS OF THE INDIAN ACADEMY OF SCIENCES SECTION B 87: 147 (1978). / PROCEEDINGS OF THE INDIAN ACADEMY OF SCIENCES SECTION B (1978)
SHEEHAN, K, STUDIES OF ESTERASE-6 IN DROSOPHILA-MELANOGASTER .3. DEVELOPMENTAL PATTERN AND TISSUE DISTRIBUTION, INSECT BIOCHEMISTRY 9: 443 (1979). (10.1016/0020-1790(79)90062-3) / INSECT BIOCHEMISTRY (1979)
STANLEYSAMUELSO.DW, ARACHIDONIC AND OTHER LONG-CHAIN POLY-UNSATURATED FATTY-ACIDS IN SPERMATOPHORES AND SPERMATHECAE OF TELEOGRYLLUS-COMMODUS - SIGNIFICANCE IN PROSTAGLANDIN-MEDIATED REPRODUCTIVE-BEHAVIOR, JOURNAL OF INSECT PHYSIOLOGY 29: 41 (1983). (10.1016/0022-1910(83)90104-X) / JOURNAL OF INSECT PHYSIOLOGY (1983)
TEMPLETON, A.R., SCREW WORM PROBLEM: 83 (1978). / SCREW WORM PROBLEM (1978)
TOMPKINS, L, COURTSHIP-STIMULATING VOLATILE COMPOUNDS FROM NORMAL AND MUTANT DROSOPHILA, JOURNAL OF INSECT PHYSIOLOGY 26: 689 (1980). (10.1016/0022-1910(80)90042-6) / JOURNAL OF INSECT PHYSIOLOGY (1980)
TOMPKINS, L, THE DIFFERENT EFFECTS ON COURTSHIP OF VOLATILE COMPOUNDS FROM MATED AND VIRGIN DROSOPHILA-FEMALES, JOURNAL OF INSECT PHYSIOLOGY 27: 17 (1981). (10.1016/0022-1910(81)90026-3) / JOURNAL OF INSECT PHYSIOLOGY (1981)
TOMPKINS, L, DROSOPHILA MALES PRODUCE A PHEROMONE WHICH INHIBITS COURTSHIP, ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES 36: 694 (1981). (10.1515/znc-1981-7-832) / ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES (1981)
WHITMORE, D, ORIGIN OF HEMOLYMPH CARBOXYLESTERASES INDUCED BY INSECT JUVENILE-HORMONE, MOLECULAR AND CELLULAR ENDOCRINOLOGY 1: 37 (1974). (10.1016/0303-7207(74)90037-9) / MOLECULAR AND CELLULAR ENDOCRINOLOGY (1974)
WRIGHT, TRF, A JOMOLOGOUS GENE-ENZYME SYSTEM, ESTERASE 6, IN DROSOPHILA MELANOGASTER AND D. SIMULANS, GENETICS 48: 1717 (1963). (10.1093/genetics/48.12.1717) / GENETICS (1963)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 2:37 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 4:59 a.m.)
Indexed	1 month, 4 weeks ago (July 1, 2025, 7:30 a.m.)
Issued	41 years, 10 months ago (Oct. 28, 1983)
Published	41 years, 10 months ago (Oct. 28, 1983)
Published Print	41 years, 10 months ago (Oct. 28, 1983)

Funders 0

None

BibTeX

@article{Mane_1983, title={Male Esterase 6 Catalyzes the Synthesis of a Sex Pheromone in Drosophila melanogaster Females}, volume={222}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.222.4622.419}, DOI={10.1126/science.222.4622.419}, number={4622}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Mane, Suresh D. and Tompkins, Laurie and Richmond, Rollin C.}, year={1983}, month=oct, pages={419–421} }

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