DOI: 10.1126/science.2218531. Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

10.1126/science.2218531

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The amyloid β protein is deposited in the brains of patients with Alzheimer's disease but its pathogenic role is unknown. In culture, the amyloid β protein was neurotrophic to undifferentiated hippocampal neurons at low concentrations and neurotoxic to mature neurons at higher concentrations. In differentiated neurons, amyloid β protein caused dendritic and axonal retraction followed by neuronal death. A portion of the amyloid β protein (amino acids 25 to 35) mediated both the trophic and toxic effects and was homologous to the tachykinin neuropeptide family. The effects of the amyloid β protein were mimicked by tachykinin antagonists and completely reversed by specific tachykinin agonists. Thus, the amyloid β protein could function as a neurotrophic factor for differentiating neurons, but at high concentrations in mature neurons, as in Alzheimer's disease, could cause neuronal degeneration.

Bibliography

Yankner, B. A., Duffy, L. K., & Kirschner, D. A. (1990). Neurotrophic and Neurotoxic Effects of Amyloid Î² Protein: Reversal by Tachykinin Neuropeptides. Science, 250(4978), 279â282.

Authors 3

Bruce A. Yankner (first)
Lawrence K. Duffy (additional)
Daniel A. Kirschner (additional)

References 33 Referenced 1,637

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10.1126/science.2474201

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 2:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, midnight)
Indexed	3 days, 15 hours ago (Aug. 29, 2025, 6:35 a.m.)
Issued	34 years, 10 months ago (Oct. 12, 1990)
Published	34 years, 10 months ago (Oct. 12, 1990)
Published Print	34 years, 10 months ago (Oct. 12, 1990)

Funders 0

None

BibTeX

@article{Yankner_1990, title={Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides}, volume={250}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2218531}, DOI={10.1126/science.2218531}, number={4978}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Yankner, Bruce A. and Duffy, Lawrence K. and Kirschner, Daniel A.}, year={1990}, month=oct, pages={279–282} }

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