Cell Cycle Control of DNA Replication by a Homologue from Human Cells of the p34 cdc2 Protein Kinase
10.1126/science.2173140
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

The regulation of DNA replication during the eukaryotic cell cycle was studied in a system where cell free replication of simian virus 40 (SV40) DNA was used as a model for chromosome replication. A factor, RF-S, was partially purified from human S phase cells based on its ability to activate DNA replication in extracts from G 1 cells. RF-S contained a human homologue of the Schizosaccharomyces pombe p34 cdc2 kinase, and this kinase was necessary for RF-S activity. The limiting step in activation of the p34 kinase at the G 1 to S transition may be its association with a cyclin since addition of cyclin A to a G 1 extract was sufficient to start DNA replication. These observations suggest that the role of p34 cdc2 in controlling the start of DNA synthesis has been conserved in evolution.

Bibliography

D’Urso, G., Marraccino, R. L., Marshak, D. R., & Roberts, J. M. (1990). Cell Cycle Control of DNA Replication by a Homologue from Human Cells of the p34 cdc2 Protein Kinase. Science, 250(4982), 786–791.

Authors 4
  1. Gennaro D'Urso (first)
  2. Robert L. Marraccino (additional)
  3. Daniel R. Marshak (additional)
  4. James M. Roberts (additional)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited 1 year, 7 months ago (Jan. 12, 2024, 4:52 a.m.)
Indexed 2 months, 1 week ago (June 21, 2025, 12:28 a.m.)
Issued 34 years, 9 months ago (Nov. 9, 1990)
Published 34 years, 9 months ago (Nov. 9, 1990)
Published Print 34 years, 9 months ago (Nov. 9, 1990)
Funders 0

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@article{D_Urso_1990, title={Cell Cycle Control of DNA Replication by a Homologue from Human Cells of the p34 cdc2 Protein Kinase}, volume={250}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2173140}, DOI={10.1126/science.2173140}, number={4982}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={D’Urso, Gennaro and Marraccino, Robert L. and Marshak, Daniel R. and Roberts, James M.}, year={1990}, month=nov, pages={786–791} }