DOI: 10.1126/science.2163544. Mediation of Wound-Related Rous Sarcoma Virus Tumorigenesis by TGF-β

Mediation of Wound-Related Rous Sarcoma Virus Tumorigenesis by TGF-β

10.1126/science.2163544

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

In Rous sarcoma virus (RSV)-infected chickens, wounding leads to tumor formation with nearly 100% frequency in tissues that would otherwise remain tumor-free. Identifying molecular mediators of this phenomenon should yield important clues to the mechanisms involved in RSV tumorigenesis. Immunohistochemical staining showed that TGF-β is present locally shortly after wounding, but not in unwounded controls. In addition, subcutaneous administration of recombinant transforming growth factor-β1 (TGF-β1) could substitute completely for wounding in tumor induction. A treatment protocol of four doses of 800 nanograms of TGF-β resulted in v- src -expressing tumors with 100% frequency; four doses of only 10 nanograms still led to tumor formation in 80% of the animals. This effect was specific, as other growth factors with suggested roles in wound healing did not elicit the same response. Epidermal growth factor (EGF) or TGF-α had no effect, and platelet-derived growth factor (PDGF) or insulin-like growth factor-1 (IGF-1) yielded only occasional tumors after longer latency. TGF-β release during the wound-healing response may thus be a critical event that creates a conducive environment for RSV tumorigenesis and may act as a cofactor for transformation in this system.

Bibliography

Sieweke, M. H., Thompson, N. L., Sporn, M. B., & Bissell, M. J. (1990). Mediation of Wound-Related Rous Sarcoma Virus Tumorigenesis by TGF-Î². Science, 248(4963), 1656â1660.

Authors 4

Michael H. Sieweke (first)
Nancy L. Thompson (additional)
Michael B. Sporn (additional)
Mina J. Bissell (additional)

References 30 Referenced 154

AKHURST, R.J., LOCALIZED PRODUCTION OF TGF-BETA MESSENGER-RNA IN TUMOR PROMOTER-STIMULATED MOUSE EPIDERMIS, NATURE 331: 363 (1988). (10.1038/331363a0) / NATURE (1988)
ASSOIAN, R.K., EXPRESSION AND SECRETION OF TYPE-BETA TRANSFORMING GROWTH-FACTOR BY ACTIVATED HUMAN MACROPHAGES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 6020 (1987). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1987)
BAUER, G, EPSTEIN-BARR VIRUS-INDUCING FACTOR - A GROWTH-FACTOR WITH TUMOR PROMOTING ACTIVITY, JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 109: A48 (1985). / JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (1985)
BRYAN, R.W., J NATL CANCER I 24: 221 (1960). / J NATL CANCER I (1960)
CLARK RAF MOL CELLULAR BIOL WO (1988).
DOLBERG, D.S., INABILITY OF ROUS-SARCOMA VIRUS TO CAUSE SARCOMAS IN THE AVIAN EMBRYO, NATURE 309: 552 (1984). (10.1038/309552a0) / NATURE (1984)
10.1126/science.2996144
DVORAK, H.F., TUMORS - WOUNDS THAT DO NOT HEAL - SIMILARITIES BETWEEN TUMOR STROMA GENERATION AND WOUND-HEALING, NEW ENGLAND JOURNAL OF MEDICINE 315: 1650 (1986). (10.1056/NEJM198612253152606) / NEW ENGLAND JOURNAL OF MEDICINE (1986)
FLANDERS, K.C., TRANSFORMING GROWTH FACTOR-BETA-1 - HISTOCHEMICAL-LOCALIZATION WITH ANTIBODIES TO DIFFERENT EPITOPES, JOURNAL OF CELL BIOLOGY 108: 653 (1989). (10.1083/jcb.108.2.653) / JOURNAL OF CELL BIOLOGY (1989)
FUERSTENBERGER, G, INT J CANCER 43: 915 (1989). (10.1002/ijc.2910430531) / INT J CANCER (1989)
10.1126/science.7123245
GROTENDORST, G.R., PRODUCTION OF TRANSFORMING GROWTH-FACTOR BETA BY HUMAN PERIPHERAL-BLOOD MONOCYTES AND NEUTROPHILS, JOURNAL OF CELLULAR PHYSIOLOGY 140: 396 (1989). (10.1002/jcp.1041400226) / JOURNAL OF CELLULAR PHYSIOLOGY (1989)
HAMEL, E, TRANSFORMING GROWTH FACTOR-BETA AS A POTENT PROMOTER IN 2-STAGE BALB/C 3T3 CELL-TRANSFORMATION, CANCER RESEARCH 48: 2832 (1988). / CANCER RESEARCH (1988)
KESKIOJA, J, TRANSFORMING GROWTH-FACTORS IN THE REGULATION OF MALIGNANT-CELL GROWTH AND INVASION, CANCER INVESTIGATION 6: 705 (1988). (10.3109/07357908809078038) / CANCER INVESTIGATION (1988)
LEOF, E.B., INDUCTION OF C-SIS MESSENGER-RNA AND ACTIVITY SIMILAR TO PLATELET-DERIVED GROWTH-FACTOR BY TRANSFORMING GROWTH-FACTOR-BETA - A PROPOSED MODEL FOR INDIRECT MITOGENESIS INVOLVING AUTOCRINE ACTIVITY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 2453 (1986). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1986)
MILFORD, J.J., Growth of a chicken sarcoma virus in the chick embryo in the absence of neoplasia, CANCER RESEARCH 3: 578 (1943). / CANCER RESEARCH (1943)
10.1126/science.2442813
PARDUE, M.L., NUCLEIC ACID HYBRIDI: 179 (1985). / NUCLEIC ACID HYBRIDI (1985)
PIERCE, G.F., TRANSFORMING GROWTH FACTOR-BETA REVERSES THE GLUCOCORTICOID-INDUCED WOUND-HEALING DEFICIT IN RATS - POSSIBLE REGULATION IN MACROPHAGES BY PLATELET-DERIVED GROWTH-FACTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 2229 (1989). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1989)
ROBERTS, A.B., TRANSFORMING GROWTH FACTOR-BETA - POSSIBLE ROLES IN CARCINOGENESIS, BRITISH JOURNAL OF CANCER 57: 594 (1988). (10.1038/bjc.1988.135) / BRITISH JOURNAL OF CANCER (1988)
ROBERTS, A.B., TRANSFORMING GROWTH-FACTOR TYPE-BETA - RAPID INDUCTION OF FIBROSIS AND ANGIOGENESIS INVIVO AND STIMULATION OF COLLAGEN FORMATION INVITRO, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 4167 (1986). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1986)
ROBERTS, A.B., TRANSFORMING GROWTH FACTOR-BETA - BIOCHEMISTRY AND ROLES IN EMBRYOGENESIS, TISSUE-REPAIR AND REMODELING, AND CARCINOGENESIS, RECENT PROGRESS IN HORMONE RESEARCH 44: 157 (1988). / RECENT PROGRESS IN HORMONE RESEARCH (1988)
ROUS, P, A sarcoma of the fowl transmissible by an agent from the tumor cells., JOURNAL OF EXPERIMENTAL MEDICINE 13: 397 (1911). (10.1084/jem.13.4.397) / JOURNAL OF EXPERIMENTAL MEDICINE (1911)
SIEWEKE, M.H., EVALUATION OF THE COCARCINOGENIC EFFECT OF WOUNDING IN ROUS-SARCOMA VIRUS TUMORIGENESIS, CANCER RESEARCH 49: 6419 (1989). / CANCER RESEARCH (1989)
SIEWEKE M.H. unpublished data.
SPORN, M.B., BIOFACTORS 1: 89 (1988). / BIOFACTORS (1988)
10.1083/jcb.105.3.1039
10.1126/science.6572416
TEICH, N, RNA TUMOR VIRUSES: 785 (1982). / RNA TUMOR VIRUSES (1982)
Wakefield L. M. Tumor Suppressor Genes (1990).

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 4:18 a.m.)
Indexed	3 weeks, 1 day ago (Aug. 6, 2025, 8:31 a.m.)
Issued	35 years, 1 month ago (June 29, 1990)
Published	35 years, 1 month ago (June 29, 1990)
Published Print	35 years, 1 month ago (June 29, 1990)

Funders 0

None

BibTeX

@article{Sieweke_1990, title={Mediation of Wound-Related Rous Sarcoma Virus Tumorigenesis by TGF-β}, volume={248}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2163544}, DOI={10.1126/science.2163544}, number={4963}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Sieweke, Michael H. and Thompson, Nancy L. and Sporn, Michael B. and Bissell, Mina J.}, year={1990}, month=jun, pages={1656–1660} }

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}