DOI: 10.1126/science.2157286. Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

10.1126/science.2157286

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Human papillomavirus type 16 (HPV-16) is a DNA tumor virus that is associated with human anogenital cancers and encodes two transforming proteins, E6 and E7. The E7 protein has been shown to bind to the retinoblastoma tumor suppressor gene product, pRB. This study shows that the E6 protein of HPV-16 is capable of binding to the cellular p53 protein. The ability of the E6 proteins from different human papillomaviruses to form complexes with p53 was assayed and found to correlate with the in vivo clinical behavior and the in vitro transforming activity of these different papillomaviruses. The wild-type p53 protein has tumor suppressor properties and has also been found in association with large T antigen and the E1B 55-kilodalton protein in cells transformed by SV40 and by adenovirus type 5, respectively, providing further evidence that the human papillomaviruses, the adenoviruses, and SV40 may effect similar cellular pathways in transformation.

Bibliography

Werness, B. A., Levine, A. J., & Howley, P. M. (1990). Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53. Science, 248(4951), 76â79.

Authors 3

Bruce A. Werness (first)
Arnold J. Levine (additional)
Peter M. Howley (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 12, 2024, 5:15 a.m.)
Indexed	1 month ago (July 26, 2025, 5:17 a.m.)
Issued	35 years, 4 months ago (April 6, 1990)
Published	35 years, 4 months ago (April 6, 1990)
Published Print	35 years, 4 months ago (April 6, 1990)

Funders 0

None

BibTeX

@article{Werness_1990, title={Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53}, volume={248}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2157286}, DOI={10.1126/science.2157286}, number={4951}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Werness, Bruce A. and Levine, Arnold J. and Howley, Peter M.}, year={1990}, month=apr, pages={76–79} }

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