At the Crossroads of Chemistry and Immunology: Catalytic Antibodies
10.1126/science.2024118
Crossref journal-article
American Association for the Advancement of Science (AAAS)
Science (221)
Abstract

Immunochemistry has historically focused on the nature of antigenicity and antibody-antigen recognition. However, in the last 5 years, the field of immunochemistry has taken a new direction. With the aid of mechanistic and synthetic chemistry, the vast network of molecules and cells of the immune system has been tapped to produce antibodies with a new function—catalytic antibodies. Because antibodies can be generated that selectively bind almost any molecule of interest, this new technology offers the potential to tailor-make highly selective catalysts for applications in biology, chemistry, and medicine. In addition, catalytic antibodies provide fundamental insight into important aspects of biological catalysis, including the importance of transition-state stabilization, proximity effects, general acid and base catalysts, electrophilic and nucleophilic catalysis, and strain.

Bibliography

Lerner, R. A., Benkovic, S. J., & Schultz, P. G. (1991). At the Crossroads of Chemistry and Immunology: Catalytic Antibodies. Science, 252(5006), 659–667.

Authors 3
  1. Richard A. Lerner (first)
  2. Stephen J. Benkovic (additional)
  3. Peter G. Schultz (additional)
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Dates
Type When
Created 18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited 1 year, 7 months ago (Jan. 11, 2024, 9:25 p.m.)
Indexed 1 day, 16 hours ago (Aug. 26, 2025, 2:47 a.m.)
Issued 34 years, 3 months ago (May 3, 1991)
Published 34 years, 3 months ago (May 3, 1991)
Published Print 34 years, 3 months ago (May 3, 1991)
Funders 0

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@article{Lerner_1991, title={At the Crossroads of Chemistry and Immunology: Catalytic Antibodies}, volume={252}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.2024118}, DOI={10.1126/science.2024118}, number={5006}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Lerner, Richard A. and Benkovic, Stephen J. and Schultz, Peter G.}, year={1991}, month=may, pages={659–667} }