DOI: 10.1126/science.197604. Selective Destruction of Neurons by a Transmitter Agonist

Selective Destruction of Neurons by a Transmitter Agonist

10.1126/science.197604

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Microinjection of nanomole amounts of kainic acid, a heterocyclic analog of glutamate, into the cerebellums of adult hamsters and rats causes rapid degeneration of Purkinje, basket, stellate, and Golgi II cells, neurons that receive synaptic input from granule cells, whereas the granule cells themselves are spared. This selectivity is consistent with the evidence that glutamate is the granule cell transmitter and supports the hypothesis that kainic acid exerts its neurotoxic effects through glutamate receptors.

Bibliography

Herndon, R. M., & Coyle, J. T. (1977). Selective Destruction of Neurons by a Transmitter Agonist. Science, 198(4312), 71â72.

Authors 2

Robert M. Herndon (first)
Joseph T. Coyle (additional)

References 19 Referenced 175

AMANO, T, NEUROTRANSMITTER SYNTHESIS BY NEUROBLASTOMA CLONES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 258 (1972). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1972)
BRAIN, W.R., REMOTE EFFECTS CANCE: 17 (1965). / REMOTE EFFECTS CANCE (1965)
BUU, N.T., RECEPTORS FOR AMINO-ACIDS IN EXCITABLE TISSUES, GENERAL PHARMACOLOGY 7: 5 (1976). (10.1016/0306-3623(76)90026-4) / GENERAL PHARMACOLOGY (1976)
CHRISTOMANOS, A, Clinical observations and pathological-anatomical findings in the central nervous system with the thiophene of poisoned dogs (Contribution to the issue of the selectivity of toxin effects in the central nervous system), ZEITSCHRIFT FUR DIE GESAMTE NEUROLOGIE UND PSYCHIATRIE 144: 1 (1933). (10.1007/BF02870270) / ZEITSCHRIFT FUR DIE GESAMTE NEUROLOGIE UND PSYCHIATRIE (1933)
10.1038/263244a0
COYLE, J.T., CLINICAL, NEUROPATHOLOGIC AND PHARMACOLOGIC ASPECTS OF HUNTINGTONS-DISEASE - CORRELATES WITH A NEW ANIMAL-MODEL, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY 1: 13 (1977). (10.1016/0364-7722(77)90025-X) / PROGRESS IN NEURO-PSYCHOPHARMACOLOGY (1977)
ECCLES J.C. CEREBELLUM NEURONAL (1967).
HERNDON, R.M., THIOPHEN INDUCED GRANULE CELL NECROSIS IN RAT CEREBELLUM - AN ELECTRON MICROSCOPIC STUDY, EXPERIMENTAL BRAIN RESEARCH 6: 49 (1968). / EXPERIMENTAL BRAIN RESEARCH (1968)
HUDSON, D.B., NEUROCHEM RES 1: 83 (1976). (10.1007/BF00965634) / NEUROCHEM RES (1976)
HUNTER, D, FOCAL CEREBRAL AND CEREBELLAR ATROPHY IN A HUMAN SUBJECT DUE TO ORGANIC MERCURY COMPOUNDS, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 17: 235 (1954). (10.1136/jnnp.17.4.235) / JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (1954)
KOKENGE, R, NEUROLOGICAL SEQUELAE FOLLOWING DILANTIN OVERDOSE IN A PATIENT AND IN EXPERIMENTAL ANIMALS, NEUROLOGY 15: 823 (1965). (10.1212/WNL.15.9.823) / NEUROLOGY (1965)
MACKENZIE, I, BRITISH MEDICAL JOURNAL 1: 406 (1935). (10.1136/bmj.1.3869.406) / BRITISH MEDICAL JOURNAL (1935)
MCBRIDE, W.J., EFFECTS OF SELECTIVE DOSES OF X-IRRADIATION ON LEVELS OF SEVERAL AMINO-ACIDS IN CEREBELLUM OF RAT, NEUROCHEMICAL RESEARCH 1: 141 (1976). (10.1007/BF00966106) / NEUROCHEMICAL RESEARCH (1976)
METTLER, F.A., CHEMICAL CEREBELLAR DECORTICATION, ANATOMICAL RECORD 169: 379 (1971). / ANATOMICAL RECORD (1971)
OLNEY, J.W., KAINIC ACID - POWERFUL NEUROTOXIC ANALOG OF GLUTAMATE, BRAIN RESEARCH 77: 507 (1974). (10.1016/0006-8993(74)90640-4) / BRAIN RESEARCH (1974)
SCHWARCZ, R, STRIATAL LESIONS WITH KAINIC ACID - NEUROCHEMICAL CHARACTERISTICS, BRAIN RESEARCH 127: 235 (1977). (10.1016/0006-8993(77)90538-8) / BRAIN RESEARCH (1977)
SEILER, G, ROLE OF SPECIFIC EOSINOPHIL GRANULES IN EOSINOPHIL-INDUCED EXPERIMENTAL ENCEPHALITIS, NEUROLOGY 19: 478 (1969). (10.1212/WNL.19.5.478) / NEUROLOGY (1969)
SNYDER, S.H., METABOLIC COMPARTMEN: 1 (1975). / METABOLIC COMPARTMEN (1975)
YOUNG, A.B., GLUTAMIC-ACID - SELECTIVE DEPLETION BY VIRAL INDUCED GRANULE CELL LOLL IN HAMSTER CEREBELLUM, BRAIN RESEARCH 73: 1 (1974). (10.1016/0006-8993(74)91002-6) / BRAIN RESEARCH (1974)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 12:03 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 9:43 p.m.)
Indexed	4 months, 1 week ago (April 22, 2025, 2:45 a.m.)
Issued	47 years, 10 months ago (Oct. 7, 1977)
Published	47 years, 10 months ago (Oct. 7, 1977)
Published Print	47 years, 10 months ago (Oct. 7, 1977)

Funders 0

None

BibTeX

@article{Herndon_1977, title={Selective Destruction of Neurons by a Transmitter Agonist}, volume={198}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.197604}, DOI={10.1126/science.197604}, number={4312}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Herndon, Robert M. and Coyle, Joseph T.}, year={1977}, month=oct, pages={71–72} }

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