DOI: 10.1126/science.1957173. DNA Bending by Fos and Jun: The Flexible Hinge Model

DNA Bending by Fos and Jun: The Flexible Hinge Model

10.1126/science.1957173

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

DNA bending is essential for the assembly of multiprotein complexes that contact several DNA sequence elements. An approach based on phasing analysis was developed that allows determination of both the directed DNA bend angle and the orientation of DNA bending. This technique has been applied to the analysis of DNA bending by the transcription regulatory proteins Fos and Jun. Complexes that contained different combinations of full-length and truncated Fos and Jun induced DNA bends of different magnitudes and orientations. The DNA bends induced by the individual proteins were determined on the basis of a quantitative model for DNA bending by dimeric complexes. This information was used to visualize the consequences of DNA bending by Fos and Jun for the structures of Fos-Jun-DNA and Jun-DNA complexes.

Bibliography

Kerppola, T. K., & Curran, T. (1991). DNA Bending by Fos and Jun: The Flexible Hinge Model. Science, 254(5035), 1210â1214.

Authors 2

Tom K. Kerppola (first)
Tom Curran (additional)

References 38 Referenced 124

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COHEN, D.R., ANALYSIS OF DIMERIZATION AND DNA-BINDING FUNCTIONS IN FOS AND JUN BY DOMAIN-SWAPPING - INVOLVEMENT OF RESIDUES OUTSIDE THE LEUCINE ZIPPER BASIC REGION, ONCOGENE 5: 929 (1990). / ONCOGENE (1990)
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GOBER, J.W., INTEGRATION HOST FACTOR IS REQUIRED FOR THE ACTIVATION OF DEVELOPMENTALLY REGULATED GENES IN CAULOBACTER, GENES & DEVELOPMENT 4: 1494 (1990). (10.1101/gad.4.9.1494) / GENES & DEVELOPMENT (1990)
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HOOVER, T.R., THE INTEGRATION HOST FACTOR STIMULATES INTERACTION OF RNA-POLYMERASE WITH NIFA, THE TRANSCRIPTIONAL ACTIVATOR FOR NITROGEN-FIXATION OPERONS, CELL 63: 11 (1990). (10.1016/0092-8674(90)90284-L) / CELL (1990)
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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 5:09 p.m.)
Indexed	3 months, 1 week ago (May 20, 2025, 9:31 a.m.)
Issued	33 years, 9 months ago (Nov. 22, 1991)
Published	33 years, 9 months ago (Nov. 22, 1991)
Published Print	33 years, 9 months ago (Nov. 22, 1991)

Funders 0

None

BibTeX

@article{Kerppola_1991, title={DNA Bending by Fos and Jun: The Flexible Hinge Model}, volume={254}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1957173}, DOI={10.1126/science.1957173}, number={5035}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Kerppola, Tom K. and Curran, Tom}, year={1991}, month=nov, pages={1210–1214} }

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