DOI: 10.1126/science.1948031. Establishment of Cell Type by Compartmentalized Activation of a Transcription Factor

Establishment of Cell Type by Compartmentalized Activation of a Transcription Factor

10.1126/science.1948031

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Early in the process of spore formation in Bacillus subtilis a septum is formed that partitions the sporangium into daughter cells called the forespore and the mother cell. The daughter cells each have their own chromosome but follow dissimilar programs of gene expression. Differential gene expression in the forespore is now shown to be established by the compartmentalized activity of the transcription factor σ F . The σ F factor is produced prior to septation, but is active only in the forespore compartment of the post-septation sporangium. The σ F factor is controlled by the products of sporulation operons spoIIA and spoIIE , which may be responsible for confining its activity to one of the daughter cells.

Bibliography

Margolis, P., Driks, A., & Losick, R. (1991). Establishment of Cell Type by Compartmentalized Activation of a Transcription Factor. Science, 254(5031), 562â565.

Authors 3

Peter Margolis (first)
Adam Driks (additional)
Richard Losick (additional)

References 41 Referenced 142

CUTTING, S, FORESPORE-SPECIFIC TRANSCRIPTION OF A GENE IN THE SIGNAL TRANSDUCTION PATHWAY THAT GOVERNS PRO-SIGMA-K PROCESSING IN BACILLUS-SUBTILIS, GENES & DEVELOPMENT 5: 456 (1991). (10.1101/gad.5.3.456) / GENES & DEVELOPMENT (1991)
Driks, A., Proceedings of the National Academy of Sciences of the United States of America 88: 9934 (1991). / Proceedings of the National Academy of Sciences of the United States of America (1991)
DRIKS A unpublished data.
ERRINGTON, J, DUPLICATED SPORULATION GENES IN BACTERIA - IMPLICATIONS FOR SIMPLE DEVELOPMENTAL SYSTEMS, FEBS LETTERS 188: 184 (1985). (10.1016/0014-5793(85)80368-9) / FEBS LETTERS (1985)
Errington, J., Genetics and Biotechnology of Bacilli 3: 257 (1990). / Genetics and Biotechnology of Bacilli (1990)
ERRINGTON, J, USE OF A LACZ GENE FUSION TO DETERMINE THE DEPENDENCE PATTERN OF SPORULATION OPERON SPOIIA IN SPO MUTANTS OF BACILLUS-SUBTILIS, JOURNAL OF GENERAL MICROBIOLOGY 132: 2967 (1986). / JOURNAL OF GENERAL MICROBIOLOGY (1986)
FORT, P, NUCLEOTIDE-SEQUENCE OF SPORULATION LOCUS SPOIIA IN BACILLUS-SUBTILIS, JOURNAL OF GENERAL MICROBIOLOGY 130: 2147 (1984). / JOURNAL OF GENERAL MICROBIOLOGY (1984)
FOULGER, D, THE ROLE OF THE SPORULATION GENE SPOIIIE IN THE REGULATION OF PRESPORE-SPECIFIC GENE-EXPRESSION IN BACILLUS-SUBTILIS, MOLECULAR MICROBIOLOGY 3: 1247 (1989). (10.1111/j.1365-2958.1989.tb00275.x) / MOLECULAR MICROBIOLOGY (1989)
FRANCESCONI, S.C., IMMUNOELECTRON MICROSCOPIC LOCALIZATION OF SMALL, ACID-SOLUBLE SPORE PROTEINS IN SPORULATING CELLS OF BACILLUS-SUBTILIS, JOURNAL OF BACTERIOLOGY 170: 5963 (1988). (10.1128/jb.170.12.5963-5967.1988) / JOURNAL OF BACTERIOLOGY (1988)
GARDELLA, T, A MUTANT ESCHERICHIA-COLI SIGMA-70 SUBUNIT OF RNA-POLYMERASE WITH ALTERED PROMOTER SPECIFICITY, JOURNAL OF MOLECULAR BIOLOGY 206: 579 (1989). (10.1016/0022-2836(89)90567-6) / JOURNAL OF MOLECULAR BIOLOGY (1989)
GHOLAMHOSEINIAN, A, TIMING OF SPOII GENE-EXPRESSION RELATIVE TO SEPTUM FORMATION DURING SPORULATION OF BACILLUS-SUBTILIS, JOURNAL OF BACTERIOLOGY 171: 5747 (1989). (10.1128/jb.171.10.5747-5749.1989) / JOURNAL OF BACTERIOLOGY (1989)
GUZMAN P COMMUNICATION.
IGO, M, GENETIC-STUDIES OF A SECONDARY RNA-POLYMERASE SIGMA FACTOR IN BACILLUS-SUBTILIS, JOURNAL OF BACTERIOLOGY 169: 3464 (1987). (10.1128/jb.169.8.3464-3469.1987) / JOURNAL OF BACTERIOLOGY (1987)
IGO, M.M., REGULATION OF A PROMOTER THAT IS UTILIZED BY MINOR FORMS OF RNA-POLYMERASE HOLOENZYME IN BACILLUS-SUBTILIS, JOURNAL OF MOLECULAR BIOLOGY 191: 615 (1986). (10.1016/0022-2836(86)90449-3) / JOURNAL OF MOLECULAR BIOLOGY (1986)
ILLING, N, GENETIC-REGULATION OF MORPHOGENESIS IN BACILLUS-SUBTILIS - ROLES OF SIGMA-E AND SIGMA-F IN PRESPORE ENGULFMENT, JOURNAL OF BACTERIOLOGY 173: 3159 (1991). (10.1128/jb.173.10.3159-3169.1991) / JOURNAL OF BACTERIOLOGY (1991)
JONAS, R.M., THE BACILLUS-SUBTILIS SPOIIG OPERON ENCODES BOTH SIGMA-E AND A GENE NECESSARY FOR SIGMA-E ACTIVATION, JOURNAL OF BACTERIOLOGY 170: 507 (1988). (10.1128/jb.170.2.507-511.1988) / JOURNAL OF BACTERIOLOGY (1988)
JONAS, R.M., INFLUENCE OF SPO MUTATIONS ON SIGMA-E SYNTHESIS IN BACILLUS-SUBTILIS, JOURNAL OF BACTERIOLOGY 171: 5226 (1989). (10.1128/jb.171.9.5226-5228.1989) / JOURNAL OF BACTERIOLOGY (1989)
KARMAZYNCAMPELL.C, TANDEM GENES ENCODING SIGMA-FACTORS FOR CONSECUTIVE STEPS OF DEVELOPMENT IN BACILLUS-SUBTILIS, GENES & DEVELOPMENT 3: 150 (1989). (10.1101/gad.3.2.150) / GENES & DEVELOPMENT (1989)
LABELL, T.L., SPORULATION-SPECIFIC SIGMA-FACTOR SIGMA-29 OF BACILLUS-SUBTILIS IS SYNTHESIZED FROM A PRECURSOR PROTEIN, P-31, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 1784 (1987). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1987)
LOSICK, R, GENETICS OF ENDOSPORE FORMATION IN BACILLUS-SUBTILIS, ANNUAL REVIEW OF GENETICS 20: 625 (1986). (10.1146/annurev.ge.20.120186.003205) / ANNUAL REVIEW OF GENETICS (1986)
MARGOLIS P unpublished data.
MASON, J.M., REGULATION OF EXPRESSION OF GENES-CODING FOR SMALL, ACID-SOLUBLE PROTEINS OF BACILLUS-SUBTILIS SPORES - STUDIES USING LACZ GENE FUSIONS, JOURNAL OF BACTERIOLOGY 170: 239 (1988). (10.1128/jb.170.1.239-244.1988) / JOURNAL OF BACTERIOLOGY (1988)
PARTRIDGE, S.R., THE ROLE OF SIGMA-F IN PRESPORE-SPECIFIC TRANSCRIPTION IN BACILLUS-SUBTILIS, MOLECULAR MICROBIOLOGY 5: 757 (1991). (10.1111/j.1365-2958.1991.tb00746.x) / MOLECULAR MICROBIOLOGY (1991)
PIGGOT, P.J., GENETIC ASPECTS OF BACTERIAL ENDOSPORE FORMATION, BACTERIOLOGICAL REVIEWS 40: 908 (1976). (10.1128/br.40.4.908-962.1976) / BACTERIOLOGICAL REVIEWS (1976)
PIGGOT, P.J., USE OF INTEGRATIONAL PLASMID VECTORS TO DEMONSTRATE THE POLYCISTRONIC NATURE OF A TRANSCRIPTIONAL UNIT (SPOIIA) REQUIRED FOR SPORULATION OF BACILLUS-SUBTILIS, JOURNAL OF GENERAL MICROBIOLOGY 130: 2123 (1984). / JOURNAL OF GENERAL MICROBIOLOGY (1984)
RATHER, P.N., NEGATIVE REGULATOR OF SIGMA-G-CONTROLLED GENE-EXPRESSION IN STATIONARY-PHASE BACILLUS-SUBTILIS, JOURNAL OF BACTERIOLOGY 172: 709 (1990). (10.1128/jb.172.2.709-715.1990) / JOURNAL OF BACTERIOLOGY (1990)
RAY, C, SUPPRESSION OF CTC PROMOTER MUTATIONS IN BACILLUS-SUBTILIS, JOURNAL OF BACTERIOLOGY 170: 900 (1988). (10.1128/jb.170.2.900-907.1988) / JOURNAL OF BACTERIOLOGY (1988)
SAVVA, D, SYNTHESIS OF SPOIIA AND SPOVA MESSENGER-RNA IN BACILLUS-SUBTILIS, JOURNAL OF GENERAL MICROBIOLOGY 132: 3005 (1986). / JOURNAL OF GENERAL MICROBIOLOGY (1986)
SCHMIDT, R, CONTROL OF DEVELOPMENTAL TRANSCRIPTION FACTOR-RHO-F BY SPORULATION REGULATORY PROTEINS SPOIIAA AND SPOIIAB IN BACILLUS-SUBTILIS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 9221 (1990). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1990)
SIEGELE, D.A., ALTERED PROMOTER RECOGNITION BY MUTANT FORMS OF THE SIGMA-70 SUBUNIT OF ESCHERICHIA-COLI RNA-POLYMERASE, JOURNAL OF MOLECULAR BIOLOGY 206: 591 (1989). (10.1016/0022-2836(89)90568-8) / JOURNAL OF MOLECULAR BIOLOGY (1989)
STRAGIER, P, PROCESSING OF A SPORULATION SIGMA FACTOR IN BACILLUS-SUBTILIS - HOW MORPHOLOGICAL STRUCTURE COULD CONTROL GENE-EXPRESSION, CELL 52: 697 (1988). (10.1016/0092-8674(88)90407-2) / CELL (1988)
STRAGIER, P, DUPLICATED SPORULATION GENES IN BACTERIA - COMMENT, FEBS LETTERS 195: 9 (1986). (10.1016/0014-5793(86)80119-3) / FEBS LETTERS (1986)
Stragier P. Prokaryotic structure and function: (1992).
STRAGIER, P, CASCADES OF SIGMA-FACTORS REVISITED, MOLECULAR MICROBIOLOGY 4: 1801 (1990). (10.1111/j.1365-2958.1990.tb02028.x) / MOLECULAR MICROBIOLOGY (1990)
SUN, D, IDENTIFICATION OF A NEW SIGMA-FACTOR INVOLVED IN COMPARTMENTALIZED GENE-EXPRESSION DURING SPORULATION OF BACILLUS-SUBTILIS, GENES & DEVELOPMENT 3: 141 (1989). (10.1101/gad.3.2.141) / GENES & DEVELOPMENT (1989)
SUN, D.X., CONTROL OF TRANSCRIPTION OF THE BACILLUS-SUBTILIS SPOIIIG GENE, WHICH CODES FOR THE FORESPORE-SPECIFIC TRANSCRIPTION FACTOR-SIGMA-G, JOURNAL OF BACTERIOLOGY 173: 2977 (1991). (10.1128/jb.173.9.2977-2984.1991) / JOURNAL OF BACTERIOLOGY (1991)
SUSSMAN, M.D., CLONING, NUCLEOTIDE-SEQUENCE, AND REGULATION OF THE BACILLUS-SUBTILIS GPR GENE, WHICH CODES FOR THE PROTEASE THAT INITIATES DEGRADATION OF SMALL, ACID-SOLUBLE PROTEINS DURING SPORE GERMINATION, JOURNAL OF BACTERIOLOGY 173: 291 (1991). (10.1128/jb.173.1.291-300.1991) / JOURNAL OF BACTERIOLOGY (1991)
TREMPY, J.E., SYNTHESIS OF SIGMA-29, AN RNA-POLYMERASE SPECIFICITY DETERMINANT, IS A DEVELOPMENTALLY REGULATED EVENT IN BACILLUS-SUBTILIS, JOURNAL OF BACTERIOLOGY 161: 340 (1985). (10.1128/jb.161.1.340-346.1985) / JOURNAL OF BACTERIOLOGY (1985)
WU, J.J., REGULATION OF TRANSCRIPTION OF THE BACILLUS-SUBTILIS SPOIIA LOCUS, JOURNAL OF BACTERIOLOGY 171: 692 (1989). (10.1128/jb.171.2.692-698.1989) / JOURNAL OF BACTERIOLOGY (1989)
YUDKIN, M.D., STRUCTURE AND FUNCTION IN A BACILLUS-SUBTILIS SPORULATION-SPECIFIC SIGMA FACTOR - MOLECULAR NATURE OF MUTATIONS IN SPOIIAC, JOURNAL OF GENERAL MICROBIOLOGY 133: 475 (1987). / JOURNAL OF GENERAL MICROBIOLOGY (1987)
ZHENG, L.B., CASCADE REGULATION OF SPORE COAT GENE-EXPRESSION IN BACILLUS-SUBTILIS, JOURNAL OF MOLECULAR BIOLOGY 212: 645 (1990). (10.1016/0022-2836(90)90227-D) / JOURNAL OF MOLECULAR BIOLOGY (1990)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 5:10 p.m.)
Indexed	1 year, 5 months ago (March 19, 2024, 2:20 p.m.)
Issued	33 years, 10 months ago (Oct. 25, 1991)
Published	33 years, 10 months ago (Oct. 25, 1991)
Published Print	33 years, 10 months ago (Oct. 25, 1991)

Funders 0

None

BibTeX

@article{Margolis_1991, title={Establishment of Cell Type by Compartmentalized Activation of a Transcription Factor}, volume={254}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1948031}, DOI={10.1126/science.1948031}, number={5031}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Margolis, Peter and Driks, Adam and Losick, Richard}, year={1991}, month=oct, pages={562–565} }

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