DOI: 10.1126/science.1900951. Peripheral Selection of the T Cell Repertoire

Peripheral Selection of the T Cell Repertoire

10.1126/science.1900951

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

T lymphocytes undergo selection events not only in the thymus, but also after they leave the thymus and reside in the periphery. Peripheral selection was found to be dependent on T cell receptor (TCR)-ligand interactions but to differ from thymic selection with regard to specificity and mechanism. Unlike thymic selection, peripheral selection required binding of antigen to the TCR, and it induced expansion of T cell clones. Tolerance to self antigens that are restricted to the periphery occurred through the elimination of self-reactive T cells and by the clonal anergy, which was associated with down-regulation of the αβ TCR and CD8.

Bibliography

Rocha, B., & von Boehmer, H. (1991). Peripheral Selection of the T Cell Repertoire. Science, 251(4998), 1225â1228.

Authors 2

Benedita Rocha (first)
Harald von Boehmer (additional)

References 27 Referenced 494

BEHLKE, M.A., EXPRESSION OF A MURINE POLYCLONAL T-CELL RECEPTOR MARKER CORRELATES WITH THE USE OF SPECIFIC MEMBERS OF THE V-BETA-8 GENE SEGMENT SUBFAMILY, JOURNAL OF EXPERIMENTAL MEDICINE 165: 257 (1987). (10.1084/jem.165.1.257) / JOURNAL OF EXPERIMENTAL MEDICINE (1987)
BERG, L.J., ANTIGEN MHC-SPECIFIC T-CELLS ARE PREFERENTIALLY EXPORTED FROM THE THYMUS IN THE PRESENCE OF THEIR MHC LIGAND, CELL 58: 1035 (1989). (10.1016/0092-8674(89)90502-3) / CELL (1989)
BLUTHMANN, H, T-CELL-SPECIFIC DELETION OF T-CELL RECEPTOR TRANSGENES ALLOWS FUNCTIONAL REARRANGEMENT OF ENDOGENOUS ALPHA-GENES AND BETA-GENES, NATURE 334: 156 (1988). (10.1038/334156a0) / NATURE (1988)
BURKLY, L.C., T-CELL TOLERANCE BY CLONAL ANERGY IN TRANSGENIC MICE WITH NONLYMPHOID EXPRESSION OF MHC CLASS-II I-E, NATURE 342: 564 (1989). (10.1038/342564a0) / NATURE (1989)
DIALYNAS, D.P., CHARACTERIZATION OF THE MURINE T-CELL SURFACE-MOLECULE, DESIGNATED L3T4, IDENTIFIED BY MONOCLONAL-ANTIBODY GK1.5 - SIMILARITY OF L3T4 TO THE HUMAN LEU-3-T4 MOLECULE, JOURNAL OF IMMUNOLOGY 131: 2445 (1983). (10.4049/jimmunol.131.5.2445) / JOURNAL OF IMMUNOLOGY (1983)
FREITAS, A.A., CONTROL MECHANISMS OF LYMPHOCYTE TRAFFIC - MODIFICATION OF TRAFFIC OF CR-51-LABELED MOUSE LYMPH-NODE CELLS BY TREATMENT WITH PLANT LECTINS IN INTACT AND SPLENECTOMIZED HOSTS, EUROPEAN JOURNAL OF IMMUNOLOGY 5: 831 (1975). (10.1002/eji.1830051207) / EUROPEAN JOURNAL OF IMMUNOLOGY (1975)
GOODNOW, C.C., INDUCTION OF SELF-TOLERANCE IN MATURE PERIPHERAL LYMPHOCYTES-B, NATURE 342: 385 (1989). (10.1038/342385a0) / NATURE (1989)
GOTTLIEB, P.D., IMMUNOGENETICS 10: 545 (1980). (10.1007/BF01572589) / IMMUNOGENETICS (1980)
10.1016/0092-8674(87)90568-X
10.1038/341746a0
KISIELOW, P, FUNCTIONAL AND PHENOTYPIC PROPERTIES OF SUB-POPULATIONS OF MURINE THYMOCYTES .1. THE BULK OF PEANUT AGGLUTININ-POSITIVE LYT-1,2,3 THYMOCYTES LACKS PRECURSORS OF CYTO-TOXIC T LYMPHOCYTES RESPONSIVE TO INTERLEUKIN 2 (T-CELL GROWTH-FACTOR), EUROPEAN JOURNAL OF IMMUNOLOGY 12: 463 (1982). (10.1002/eji.1830120603) / EUROPEAN JOURNAL OF IMMUNOLOGY (1982)
10.1038/333742a0
KISIELOW, P, POSITIVE SELECTION OF ANTIGEN-SPECIFIC T-CELLS IN THYMUS BY RESTRICTING MHC MOLECULES, NATURE 335: 730 (1988). (10.1038/335730a0) / NATURE (1988)
KUBO, R.T., CHARACTERIZATION OF A MONOCLONAL-ANTIBODY WHICH DETECTS ALL MURINE-ALPHA-BETA T-CELL RECEPTORS, JOURNAL OF IMMUNOLOGY 142: 2736 (1989). (10.4049/jimmunol.142.8.2736) / JOURNAL OF IMMUNOLOGY (1989)
10.1126/science.129.3364.1649
10.1084/jem.170.1.87
10.1038/332040a0
MILLER, JFA, EXPERIMENTAL THYMOLOGY HAS COME OF AGE, THYMUS 1: 3 (1979). / THYMUS (1979)
MILLER, R.A., T-CELL REPOPULATION FROM FUNCTIONALLY RESTRICTED SPLENIC PROGENITORS - 10,000-FOLD EXPANSION DOCUMENTED BY USING LIMITING DILUTION ANALYSES, JOURNAL OF IMMUNOLOGY 133: 2925 (1984). (10.4049/jimmunol.133.6.2925) / JOURNAL OF IMMUNOLOGY (1984)
10.1038/339622a0
PENIT, C, SEQUENTIAL EVENTS IN THYMOCYTE DIFFERENTIATION AND THYMUS REGENERATION REVEALED BY A COMBINATION OF BROMODEOXYURIDINE DNA LABELING AND ANTIMITOTIC DRUG-TREATMENT, JOURNAL OF IMMUNOLOGY 140: 3315 (1988). (10.4049/jimmunol.140.10.3315) / JOURNAL OF IMMUNOLOGY (1988)
10.1002/eji.1830190518
ROCHA, B, ACCUMULATION OF BROMODEOXYURIDINE-LABELED CELLS IN CENTRAL AND PERIPHERAL LYMPHOID ORGANS - MINIMAL ESTIMATES OF PRODUCTION AND TURNOVER RATES OF MATURE LYMPHOCYTES, EUROPEAN JOURNAL OF IMMUNOLOGY 20: 1697 (1990). (10.1002/eji.1830200812) / EUROPEAN JOURNAL OF IMMUNOLOGY (1990)
ROCHA, B, EUROPEAN JOURNAL OF IMMUNOLOGY 20: 919 (1990). (10.1002/eji.1830200430) / EUROPEAN JOURNAL OF IMMUNOLOGY (1990)
SCOLLAY, R.G., THYMUS-CELL MIGRATION QUANTITATIVE ASPECTS OF CELLULAR TRAFFIC FROM THE THYMUS TO THE PERIPHERY IN MICE, EUROPEAN JOURNAL OF IMMUNOLOGY 10: 210 (1980). (10.1002/eji.1830100310) / EUROPEAN JOURNAL OF IMMUNOLOGY (1980)
TEH, H.S., THYMIC MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS AND THE ALPHA-BETA-T-CELL RECEPTOR DETERMINE THE CD4/CD8 PHENOTYPE OF T-CELLS, NATURE 335: 229 (1988). (10.1038/335229a0) / NATURE (1988)
UEMATSU, Y, IN TRANSGENIC MICE THE INTRODUCED FUNCTIONAL T-CELL RECEPTOR BETA-GENE PREVENTS EXPRESSION OF ENDOGENOUS BETA-GENES, CELL 52: 831 (1988). (10.1016/0092-8674(88)90425-4) / CELL (1988)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 3:59 p.m.)
Indexed	1 week, 3 days ago (Aug. 20, 2025, 9:16 a.m.)
Issued	34 years, 5 months ago (March 8, 1991)
Published	34 years, 5 months ago (March 8, 1991)
Published Print	34 years, 5 months ago (March 8, 1991)

Funders 0

None

BibTeX

@article{Rocha_1991, title={Peripheral Selection of the T Cell Repertoire}, volume={251}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1900951}, DOI={10.1126/science.1900951}, number={4998}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Rocha, Benedita and von Boehmer, Harald}, year={1991}, month=mar, pages={1225–1228} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        20
      ]
    ],
    "date-time": "2025-08-20T13:16:44Z",
    "timestamp": 1755695804152
  },
  "reference-count": 27,
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "issue": "4998",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1991,
        3,
        8
      ]
    ]
  },
  "abstract": "<jats:p>T lymphocytes undergo selection events not only in the thymus, but also after they leave the thymus and reside in the periphery. Peripheral selection was found to be dependent on T cell receptor (TCR)-ligand interactions but to differ from thymic selection with regard to specificity and mechanism. Unlike thymic selection, peripheral selection required binding of antigen to the TCR, and it induced expansion of T cell clones. Tolerance to self antigens that are restricted to the periphery occurred through the elimination of self-reactive T cells and by the clonal anergy, which was associated with down-regulation of the \u03b1\u03b2 TCR and CD8.</jats:p>",
  "DOI": "10.1126/science.1900951",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        10,
        5
      ]
    ],
    "date-time": "2006-10-05T22:10:16Z",
    "timestamp": 1160086216000
  },
  "page": "1225-1228",
  "source": "Crossref",
  "is-referenced-by-count": 494,
  "title": "Peripheral Selection of the T Cell Repertoire",
  "prefix": "10.1126",
  "volume": "251",
  "author": [
    {
      "given": "Benedita",
      "family": "Rocha",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Unit\u00e9 INSERM U-25 CNRS UA-122, H\u00f4pital Necker, Paris, France."
        }
      ]
    },
    {
      "given": "Harald",
      "family": "von Boehmer",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Basel Institute for Immunology, CH-4005 Basel, Switzerland."
        }
      ]
    }
  ],
  "member": "221",
  "reference": [
    {
      "key": "e_1_2_1_1_1",
      "doi-asserted-by": "crossref",
      "first-page": "257",
      "DOI": "10.1084/jem.165.1.257",
      "volume": "165",
      "year": "1987",
      "unstructured": "BEHLKE, M.A., EXPRESSION OF A MURINE POLYCLONAL T-CELL RECEPTOR MARKER CORRELATES WITH THE USE OF SPECIFIC MEMBERS OF THE V-BETA-8 GENE SEGMENT SUBFAMILY, JOURNAL OF EXPERIMENTAL MEDICINE 165: 257 (1987).",
      "journal-title": "JOURNAL OF EXPERIMENTAL MEDICINE"
    },
    {
      "key": "e_1_2_1_2_1",
      "doi-asserted-by": "crossref",
      "first-page": "1035",
      "DOI": "10.1016/0092-8674(89)90502-3",
      "volume": "58",
      "year": "1989",
      "unstructured": "BERG, L.J., ANTIGEN MHC-SPECIFIC T-CELLS ARE PREFERENTIALLY EXPORTED FROM THE THYMUS IN THE PRESENCE OF THEIR MHC LIGAND, CELL 58: 1035 (1989).",
      "journal-title": "CELL"
    },
    {
      "key": "e_1_2_1_3_1",
      "doi-asserted-by": "crossref",
      "first-page": "156",
      "DOI": "10.1038/334156a0",
      "volume": "334",
      "year": "1988",
      "unstructured": "BLUTHMANN, H, T-CELL-SPECIFIC DELETION OF T-CELL RECEPTOR TRANSGENES ALLOWS FUNCTIONAL REARRANGEMENT OF ENDOGENOUS ALPHA-GENES AND BETA-GENES, NATURE 334: 156 (1988).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_4_1",
      "doi-asserted-by": "crossref",
      "first-page": "564",
      "DOI": "10.1038/342564a0",
      "volume": "342",
      "year": "1989",
      "unstructured": "BURKLY, L.C., T-CELL TOLERANCE BY CLONAL ANERGY IN TRANSGENIC MICE WITH NONLYMPHOID EXPRESSION OF MHC CLASS-II I-E, NATURE 342: 564 (1989).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_5_1",
      "doi-asserted-by": "crossref",
      "first-page": "2445",
      "DOI": "10.4049/jimmunol.131.5.2445",
      "volume": "131",
      "year": "1983",
      "unstructured": "DIALYNAS, D.P., CHARACTERIZATION OF THE MURINE T-CELL SURFACE-MOLECULE, DESIGNATED L3T4, IDENTIFIED BY MONOCLONAL-ANTIBODY GK1.5 - SIMILARITY OF L3T4 TO THE HUMAN LEU-3-T4 MOLECULE, JOURNAL OF IMMUNOLOGY 131: 2445 (1983).",
      "journal-title": "JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "crossref",
      "first-page": "831",
      "DOI": "10.1002/eji.1830051207",
      "volume": "5",
      "year": "1975",
      "unstructured": "FREITAS, A.A., CONTROL MECHANISMS OF LYMPHOCYTE TRAFFIC - MODIFICATION OF TRAFFIC OF CR-51-LABELED MOUSE LYMPH-NODE CELLS BY TREATMENT WITH PLANT LECTINS IN INTACT AND SPLENECTOMIZED HOSTS, EUROPEAN JOURNAL OF IMMUNOLOGY 5: 831 (1975).",
      "journal-title": "EUROPEAN JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_7_1",
      "doi-asserted-by": "crossref",
      "first-page": "385",
      "DOI": "10.1038/342385a0",
      "volume": "342",
      "year": "1989",
      "unstructured": "GOODNOW, C.C., INDUCTION OF SELF-TOLERANCE IN MATURE PERIPHERAL LYMPHOCYTES-B, NATURE 342: 385 (1989).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_8_1",
      "doi-asserted-by": "crossref",
      "first-page": "545",
      "DOI": "10.1007/BF01572589",
      "volume": "10",
      "year": "1980",
      "unstructured": "GOTTLIEB, P.D., IMMUNOGENETICS 10: 545 (1980).",
      "journal-title": "IMMUNOGENETICS"
    },
    {
      "key": "e_1_2_1_9_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(87)90568-X"
    },
    {
      "key": "e_1_2_1_10_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/341746a0"
    },
    {
      "key": "e_1_2_1_11_1",
      "doi-asserted-by": "crossref",
      "first-page": "463",
      "DOI": "10.1002/eji.1830120603",
      "volume": "12",
      "year": "1982",
      "unstructured": "KISIELOW, P, FUNCTIONAL AND PHENOTYPIC PROPERTIES OF SUB-POPULATIONS OF MURINE THYMOCYTES .1. THE BULK OF PEANUT AGGLUTININ-POSITIVE LYT-1,2,3 THYMOCYTES LACKS PRECURSORS OF CYTO-TOXIC T LYMPHOCYTES RESPONSIVE TO INTERLEUKIN 2 (T-CELL GROWTH-FACTOR), EUROPEAN JOURNAL OF IMMUNOLOGY 12: 463 (1982).",
      "journal-title": "EUROPEAN JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_12_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/333742a0"
    },
    {
      "key": "e_1_2_1_13_1",
      "doi-asserted-by": "crossref",
      "first-page": "730",
      "DOI": "10.1038/335730a0",
      "volume": "335",
      "year": "1988",
      "unstructured": "KISIELOW, P, POSITIVE SELECTION OF ANTIGEN-SPECIFIC T-CELLS IN THYMUS BY RESTRICTING MHC MOLECULES, NATURE 335: 730 (1988).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_14_1",
      "doi-asserted-by": "crossref",
      "first-page": "2736",
      "DOI": "10.4049/jimmunol.142.8.2736",
      "volume": "142",
      "year": "1989",
      "unstructured": "KUBO, R.T., CHARACTERIZATION OF A MONOCLONAL-ANTIBODY WHICH DETECTS ALL MURINE-ALPHA-BETA T-CELL RECEPTORS, JOURNAL OF IMMUNOLOGY 142: 2736 (1989).",
      "journal-title": "JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_15_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.129.3364.1649"
    },
    {
      "key": "e_1_2_1_16_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1084/jem.170.1.87"
    },
    {
      "key": "e_1_2_1_17_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/332040a0"
    },
    {
      "key": "e_1_2_1_18_1",
      "first-page": "3",
      "volume": "1",
      "year": "1979",
      "unstructured": "MILLER, JFA, EXPERIMENTAL THYMOLOGY HAS COME OF AGE, THYMUS 1: 3 (1979).",
      "journal-title": "THYMUS"
    },
    {
      "key": "e_1_2_1_19_1",
      "doi-asserted-by": "crossref",
      "first-page": "2925",
      "DOI": "10.4049/jimmunol.133.6.2925",
      "volume": "133",
      "year": "1984",
      "unstructured": "MILLER, R.A., T-CELL REPOPULATION FROM FUNCTIONALLY RESTRICTED SPLENIC PROGENITORS - 10,000-FOLD EXPANSION DOCUMENTED BY USING LIMITING DILUTION ANALYSES, JOURNAL OF IMMUNOLOGY 133: 2925 (1984).",
      "journal-title": "JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_20_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/339622a0"
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "crossref",
      "first-page": "3315",
      "DOI": "10.4049/jimmunol.140.10.3315",
      "volume": "140",
      "year": "1988",
      "unstructured": "PENIT, C, SEQUENTIAL EVENTS IN THYMOCYTE DIFFERENTIATION AND THYMUS REGENERATION REVEALED BY A COMBINATION OF BROMODEOXYURIDINE DNA LABELING AND ANTIMITOTIC DRUG-TREATMENT, JOURNAL OF IMMUNOLOGY 140: 3315 (1988).",
      "journal-title": "JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_22_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/eji.1830190518"
    },
    {
      "key": "e_1_2_1_23_1",
      "doi-asserted-by": "crossref",
      "first-page": "1697",
      "DOI": "10.1002/eji.1830200812",
      "volume": "20",
      "year": "1990",
      "unstructured": "ROCHA, B, ACCUMULATION OF BROMODEOXYURIDINE-LABELED CELLS IN CENTRAL AND PERIPHERAL LYMPHOID ORGANS - MINIMAL ESTIMATES OF PRODUCTION AND TURNOVER RATES OF MATURE LYMPHOCYTES, EUROPEAN JOURNAL OF IMMUNOLOGY 20: 1697 (1990).",
      "journal-title": "EUROPEAN JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_24_1",
      "doi-asserted-by": "crossref",
      "first-page": "919",
      "DOI": "10.1002/eji.1830200430",
      "volume": "20",
      "year": "1990",
      "unstructured": "ROCHA, B, EUROPEAN JOURNAL OF IMMUNOLOGY 20: 919 (1990).",
      "journal-title": "EUROPEAN JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_25_1",
      "doi-asserted-by": "crossref",
      "first-page": "210",
      "DOI": "10.1002/eji.1830100310",
      "volume": "10",
      "year": "1980",
      "unstructured": "SCOLLAY, R.G., THYMUS-CELL MIGRATION QUANTITATIVE ASPECTS OF CELLULAR TRAFFIC FROM THE THYMUS TO THE PERIPHERY IN MICE, EUROPEAN JOURNAL OF IMMUNOLOGY 10: 210 (1980).",
      "journal-title": "EUROPEAN JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_26_1",
      "doi-asserted-by": "crossref",
      "first-page": "229",
      "DOI": "10.1038/335229a0",
      "volume": "335",
      "year": "1988",
      "unstructured": "TEH, H.S., THYMIC MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS AND THE ALPHA-BETA-T-CELL RECEPTOR DETERMINE THE CD4/CD8 PHENOTYPE OF T-CELLS, NATURE 335: 229 (1988).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_27_1",
      "doi-asserted-by": "crossref",
      "first-page": "831",
      "DOI": "10.1016/0092-8674(88)90425-4",
      "volume": "52",
      "year": "1988",
      "unstructured": "UEMATSU, Y, IN TRANSGENIC MICE THE INTRODUCED FUNCTIONAL T-CELL RECEPTOR BETA-GENE PREVENTS EXPRESSION OF ENDOGENOUS BETA-GENES, CELL 52: 831 (1988).",
      "journal-title": "CELL"
    }
  ],
  "container-title": "Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.science.org/doi/pdf/10.1126/science.1900951",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        11
      ]
    ],
    "date-time": "2024-01-11T20:59:32Z",
    "timestamp": 1705006772000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.science.org/doi/10.1126/science.1900951"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1991,
        3,
        8
      ]
    ]
  },
  "references-count": 27,
  "journal-issue": {
    "issue": "4998",
    "published-print": {
      "date-parts": [
        [
          1991,
          3,
          8
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.1900951"
  ],
  "URL": "http://dx.doi.org/10.1126/science.1900951",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1991,
        3,
        8
      ]
    ]
  }
}