DOI: 10.1126/science.188131. Synaptic Transmission: Long-Lasting Potentiation by a Postsynaptic Mechanism

Synaptic Transmission: Long-Lasting Potentiation by a Postsynaptic Mechanism

10.1126/science.188131

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Slow decreases of ionic conductance across neuronal cell membranes, which generate slow synaptic potentials, can increase the effectiveness of synaptic transmission. Slow conductance decreases of sufficient magnitude increase the amplitude of monosynaptic fast excitatory postsynaptic potentials in B cells of the bullfrog sympathetic ganglion. By this postsynaptic mechanism, activation of one synaptic pathway can cause an increase in transmission, lasting several minutes, across another synapse. This may provide an important mechanism for synaptic integration and control of neuronal interaction.

Bibliography

Schulman, J. A., & Weight, F. F. (1976). Synaptic Transmission: Long-Lasting Potentiation by a Postsynaptic Mechanism. Science, 194(4272), 1437â1439.

Authors 2

Jesse A. Schulman (first)
Forrest F. Weight (additional)

References 24 Referenced 93

BENNETT, MVL, VOLTAGE THRESHOLD IN EXCITABLE CELLS DEPENDS ON STIMULUS FORM, JOURNAL OF NEUROPHYSIOLOGY 33: 585 (1970). (10.1152/jn.1970.33.5.585) / JOURNAL OF NEUROPHYSIOLOGY (1970)
BURKE, R.E., COMPOSITE NATURE OF MONOSYNAPTIC EXCITATORY POSTSYNAPTIC POTENTIAL, JOURNAL OF NEUROPHYSIOLOGY 30: 1114 (1967). (10.1152/jn.1967.30.5.1114) / JOURNAL OF NEUROPHYSIOLOGY (1967)
10.1126/science.943847
GERSCHENFELD, H.M., TRANSMITTER FUNCTION OF 5-HYDROXYTRYPTAMINE AT EXCITATORY AND INHIBITORY MONOSYNAPTIC JUNCTIONS, JOURNAL OF PHYSIOLOGY-LONDON 243: 457 (1974). (10.1113/jphysiol.1974.sp010762) / JOURNAL OF PHYSIOLOGY-LONDON (1974)
GINSBORG, B.L., J PHARMACOL EXP THER 150: 217 (1965). / J PHARMACOL EXP THER (1965)
HARTZELL, H.C., POST-SYNAPTIC POTENTIATION - INTERACTION BETWEEN QUANTA OF ACETYLCHOLINE AT SKELETAL NEUROMUSCULAR SYNAPSE, JOURNAL OF PHYSIOLOGY-LONDON 251: 427 (1975). (10.1113/jphysiol.1975.sp011102) / JOURNAL OF PHYSIOLOGY-LONDON (1975)
HUNT, C.C., STRUCTURAL AND FUNCTIONAL CHANGES IN FROG SYMPATHETIC GANGLION FOLLOWING CUTTING OF PRESYNAPTIC NERVE FIBRES, JOURNAL OF PHYSIOLOGY-LONDON 177: 1 (1965). / JOURNAL OF PHYSIOLOGY-LONDON (1965)
JOHNSON, S.E., On the question of commissural neurones in the sympathetic ganglia, JOURNAL OF COMPARATIVE NEUROLOGY 29: 385 (1918). (10.1002/cne.900290406) / JOURNAL OF COMPARATIVE NEUROLOGY (1918)
KATZ, B, A STUDY OF THE DESENSITIZATION PRODUCED BY ACETYLCHOLINE AT THE MOTOR END-PLATE, JOURNAL OF PHYSIOLOGY-LONDON 138: 63 (1957). (10.1113/jphysiol.1957.sp005838) / JOURNAL OF PHYSIOLOGY-LONDON (1957)
KATZ, B, NERVE MUSCLE SYNAPSE: 146 (1966). / NERVE MUSCLE SYNAPSE (1966)
KEHOE, J. S., JOURNAL OF PHYSIOLOGY-LONDON 244: P23 (1975). / JOURNAL OF PHYSIOLOGY-LONDON (1975)
KRNJEVIC, K, JOURNAL OF PHYSIOLOGY-LONDON 215: 247 (1971). (10.1113/jphysiol.1971.sp009467) / JOURNAL OF PHYSIOLOGY-LONDON (1971)
LIBET, B, SLOW SYNAPTIC RESPONSES AND EXCITABILITY IN SYMPATHETIC GANGLIA OF BULLFROG, JOURNAL OF NEUROPHYSIOLOGY 31: 383 (1968). (10.1152/jn.1968.31.3.383) / JOURNAL OF NEUROPHYSIOLOGY (1968)
MAGLEBY, K. L., JOURNAL OF PHYSIOLOGY-LONDON 244: 467 (1975). (10.1113/jphysiol.1975.sp010808) / JOURNAL OF PHYSIOLOGY-LONDON (1975)
NISHI, S, ELECTRICAL PROPERTIES AND ACTIVITIES OF SINGLE SYMPATHETIC NEURONS IN FROGS, JOURNAL OF CELLULAR AND COMPARATIVE PHYSIOLOGY 55: 15 (1960). (10.1002/jcp.1030550104) / JOURNAL OF CELLULAR AND COMPARATIVE PHYSIOLOGY (1960)
NISHI, S, EARLY AND LATE AFTERDISCHARGES OF AMPHIBIAN SYMPATHETIC GANGLION CELLS, JOURNAL OF NEUROPHYSIOLOGY 31: 109 (1968). (10.1152/jn.1968.31.1.109) / JOURNAL OF NEUROPHYSIOLOGY (1968)
RALL W NEURAL THEORY MODELI (1964).
SCHULMAN J UNPUBLISHED OBSERVATIONS.
10.1126/science.171.3967.192
TAKEUCHI, A, ACTIVE PHASE OF FROGS END-PLATE POTENTIAL, JOURNAL OF NEUROPHYSIOLOGY 22: 395 (1959). (10.1152/jn.1959.22.4.395) / JOURNAL OF NEUROPHYSIOLOGY (1959)
WEIGHT, F.F., NEUROSCIENCES 3RD ST: 929 (1974). / NEUROSCIENCES 3RD ST (1974)
WEIGHT, F.F., SYNAPTIC POTENTIAL R: 141 (1974). / SYNAPTIC POTENTIAL R (1974)
10.1126/science.170.3959.755
Weitsen, H., Brain Research 128: 197 (1977). (10.1016/0006-8993(77)90988-X) / Brain Research (1977)

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 11:51 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 4:25 p.m.)
Indexed	2 days, 1 hour ago (Sept. 4, 2025, 10:08 a.m.)
Issued	48 years, 8 months ago (Dec. 24, 1976)
Published	48 years, 8 months ago (Dec. 24, 1976)
Published Print	48 years, 8 months ago (Dec. 24, 1976)

Funders 0

None

BibTeX

@article{Schulman_1976, title={Synaptic Transmission: Long-Lasting Potentiation by a Postsynaptic Mechanism}, volume={194}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.188131}, DOI={10.1126/science.188131}, number={4272}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Schulman, Jesse A. and Weight, Forrest F.}, year={1976}, month=dec, pages={1437–1439} }

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