DOI: 10.1126/science.182.4116.1039. Long-Term Sensitization of a Defensive Withdrawal Reflex in <i>Aplysia</i>

Long-Term Sensitization of a Defensive Withdrawal Reflex in Aplysia

10.1126/science.182.4116.1039

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

When a weak tactile stimulus is applied to the siphon of Aplysia californica, the animal withdraws the siphon between the parapodia. This defensive withdrawal reflex can be facilitated (sensitized) if the animal is previously given 4 days of training, consisting of four brief noxious stimuli each day. The sensitization of this reflex can last for up to 3 weeks after training and is mediated by the abdominal ganglion which also mediates long-term habituation. This preparation may provide a system for analyzing the neural mechanism of long-term behavioral modifications of complexity which is intermediate between habituation and associative learning.

Bibliography

Pinsker, H. M., Hening, W. A., Carew, T. J., & Kandel, E. R. (1973). Long-Term Sensitization of a Defensive Withdrawal Reflex in Aplysia. Science, 182(4116), 1039â1042.

Authors 4

Harold M. Pinsker (first)
Wayne A. Hening (additional)
Thomas J. Carew (additional)
Eric R. Kandel (additional)

References 17 Referenced 267

10.3109/00207457109146995
10.1126/science.175.4020.451
10.1126/science.167.3926.1745
10.1037/h0029810
Kandel E. R. The Neurosciences in press.
KANDEL, E.R., CELLULAR NEUROPHYSIOLOGICAL APPROACHES IN STUDY OF LEARNING, PHYSIOLOGICAL REVIEWS 48: 65 (1968). (10.1152/physrev.1968.48.1.65) / PHYSIOLOGICAL REVIEWS (1968)
KIMBLE G.A. HILGARD MARQUIS COND (1961).
KLING J.W. SHORT TERM CHANGES N (1970).
KUPFERMANN, I, PHYSIOL REV 48: 65 (1968). (10.1152/physrev.1968.48.1.65) / PHYSIOL REV (1968)
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10.1126/science.167.3926.1743
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LUKOWIAK, K, HABITUATION AND DISHABITUATION - INTERACTIONS BETWEEN PERIPHERAL AND CENTRAL NERVOUS SYSTEMS IN APLYSIA, SCIENCE 178: 1306 (1972). (10.1126/science.178.4067.1306) / SCIENCE (1972)
10.1126/science.169.3943.379
10.1126/science.167.3926.1740
WELLS, M.J., CONDITIONING AND SENSITIZATION IN SNAILS, ANIMAL BEHAVIOUR 19: 305 (1971). (10.1016/S0003-3472(71)80011-8) / ANIMAL BEHAVIOUR (1971)
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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 10:05 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 3:51 p.m.)
Indexed	1 day ago (Sept. 3, 2025, 5:52 a.m.)
Issued	51 years, 8 months ago (Dec. 7, 1973)
Published	51 years, 8 months ago (Dec. 7, 1973)
Published Print	51 years, 8 months ago (Dec. 7, 1973)

Funders 0

None

BibTeX

@article{Pinsker_1973, title={Long-Term Sensitization of a Defensive Withdrawal Reflex in Aplysia}, volume={182}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.182.4116.1039}, DOI={10.1126/science.182.4116.1039}, number={4116}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Pinsker, Harold M. and Hening, Wayne A. and Carew, Thomas J. and Kandel, Eric R.}, year={1973}, month=dec, pages={1039–1042} }

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