DOI: 10.1126/science.179.4078.1123. Purine Overproduction in Man Associated with Increased Phosphoribosylpyrophosphate Synthetase Activity

Purine Overproduction in Man Associated with Increased Phosphoribosylpyrophosphate Synthetase Activity

10.1126/science.179.4078.1123

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

In hemolyzates from red cells of two brothers with purine overproduction and gout, activity of phosphoribosylpyrophosphate synthetase is more than twofold greater than that measured in normal or other gouty individuals. The increased enzyme activity, which is also demonstrable in fibroblasts of the one patient tested, is associated with increased production of 5-phosphoribosyl-1-pyrophosphate by intact cells, an indication that the enzyme abnormality is the basis for the purine overproduction. This genetic abnormality is an example of an increased enzyme activity producing a disease state.

Bibliography

Becker, M. A., Meyer, L. J., Wood, A. W., & Seegmiller, J. E. (1973). Purine Overproduction in Man Associated with Increased Phosphoribosylpyrophosphate Synthetase Activity. Science, 179(4078), 1123â1126.

Authors 4

Michael A. Becker (first)
Laurence J. Meyer (additional)
Alexander W. Wood (additional)
J. Edwin Seegmiller (additional)

References 37 Referenced 96

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 10:05 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 3:34 p.m.)
Indexed	2 months, 3 weeks ago (June 3, 2025, 3:46 p.m.)
Issued	52 years, 5 months ago (March 16, 1973)
Published	52 years, 5 months ago (March 16, 1973)
Published Print	52 years, 5 months ago (March 16, 1973)

Funders 0

None

BibTeX

@article{Becker_1973, title={Purine Overproduction in Man Associated with Increased Phosphoribosylpyrophosphate Synthetase Activity}, volume={179}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.179.4078.1123}, DOI={10.1126/science.179.4078.1123}, number={4078}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Becker, Michael A. and Meyer, Laurence J. and Wood, Alexander W. and Seegmiller, J. Edwin}, year={1973}, month=mar, pages={1123–1126} }

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