DOI: 10.1126/science.175.4027.1251. Nerve Growth Factor: Stimulation of Regenerative Growth of Central Noradrenergic Neurons

Nerve Growth Factor: Stimulation of Regenerative Growth of Central Noradrenergic Neurons

10.1126/science.175.4027.1251

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The growth of new axonal sprouts was studied from transected, ascending noradrenergic axons into transplants of iris tissue in the caudal hypothalamus of the rat. A single intraventricular injection of nerve growth factor, given at the time of axonal damage, resulted in an increased formation and growth of new noradrenaline sprouts 7 days later. The effect seemed to be proportional to the administered dose of nerve growth factor.

Bibliography

BjÃ¶rklund, A., & Stenevi, U. (1972). Nerve Growth Factor: Stimulation of Regenerative Growth of Central Noradrenergic Neurons. Science, 175(4027), 1251â1253.

Authors 2

Anders Björklund (first)
Ulf Stenevi (additional)

References 10 Referenced 133

BJORKLUND, A, GROWTH OF CENTRAL CATECHOLAMINE NEURONES INTO SMOOTH MUSCLE GRAFTS IN RAT MESENCEPHALON, BRAIN RESEARCH 31: 1 (1971). (10.1016/0006-8993(71)90630-5) / BRAIN RESEARCH (1971)
BJORKLUND, A, DEVELOPMENT AND GROWTH OF AXONAL SPROUTS FROM NORADRENALINE AND 5-HYDROXYTRYPTAMINE NEURONES IN RAT SPINAL CORD, BRAIN RESEARCH 31: 21 (1971). (10.1016/0006-8993(71)90631-7) / BRAIN RESEARCH (1971)
BJORKLUND, A, BRAIN RES 32: 1 (1971). (10.1016/0006-8993(71)90151-X) / BRAIN RES (1971)
FALCK, B, ACTA UNIVERSITATIS LUNDENSIS. SECTIO II 7: 1 (1965). / ACTA UNIVERSITATIS LUNDENSIS. SECTIO II (1965)
KATZMAN, R, EVIDENCE FOR REGENERATIVE AXON SPROUTING OF CENTRAL CATECHOLAMINE NEURONS IN RAT MESENCEPHALON FOLLOWING ELECTROLYTIC LESIONS, BRAIN RESEARCH 25: 579 (1971). (10.1016/0006-8993(71)90462-8) / BRAIN RESEARCH (1971)
LEVIMONTALCINI, R, EFFECTS OF THE EXTRACT OF THE MOUSE SUBMAXILLARY SALIVARY GLANDS ON THE SYMPATHETIC SYSTEM OF MAMMALS, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 85: 324 (1960). (10.1111/j.1749-6632.1960.tb49963.x) / ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (1960)
10.1152/physrev.1968.48.3.534
Scett, D., Mechanisms of Neural Regeneration: 127 (1964). / Mechanisms of Neural Regeneration (1964)
SILBERSTEIN, S.D., SYMPATHETIC REINNERVATION OF RAT IRIS IN ORGAN CULTURE - (NERVE GROWTH FACTOR/NOREPINEPHRINE UPTAKE/FLUORESCENCE), PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 68: 1121 (1971). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1971)
UNGERSTEDT U ACTA PHYSIOLOGICA SCANDINAVICA 367 (1971).

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 10:03 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 10:11 a.m.)
Indexed	1 day, 21 hours ago (Sept. 4, 2025, 10:34 a.m.)
Issued	53 years, 5 months ago (March 17, 1972)
Published	53 years, 5 months ago (March 17, 1972)
Published Print	53 years, 5 months ago (March 17, 1972)

Funders 0

None

BibTeX

@article{Bj_rklund_1972, title={Nerve Growth Factor: Stimulation of Regenerative Growth of Central Noradrenergic Neurons}, volume={175}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.175.4027.1251}, DOI={10.1126/science.175.4027.1251}, number={4027}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Björklund, Anders and Stenevi, Ulf}, year={1972}, month=mar, pages={1251–1253} }

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