DOI: 10.1126/science.173.3998.736. Biological Activity and Synthesis of an Encephalitogenic Determinant

Biological Activity and Synthesis of an Encephalitogenic Determinant

10.1126/science.173.3998.736

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

A 45-residue fragment of the basic protein of myelin is encephalitogenic in the rabbit and monkey but relatively inactive in the guinea pig. Synthetic peptides containing the sequence of a tryptic peptide of the fragment Thr-Thr-His-Tyr-Gly-Ser-Leu-Pro-Gln-Lys are moderately encephalitogenic.

Bibliography

Shapira, R., Chou, F. C.-H., McKneally, S., Urban, E., & Kibler, R. F. (1971). Biological Activity and Synthesis of an Encephalitogenic Determinant. Science, 173(3998), 736â738.

Authors 5

R. Shapira (first)
F. C-H. Chou (additional)
S. McKneally (additional)
E. Urban (additional)
R. F. Kibler (additional)

References 16 Referenced 85

CARNEGIE, P.R., EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS - DIGESTION OF BASIC PROTEIN OF HUMAN MYELIN WITH CYANOGEN BROMIDE AND TRYPSIN, IMMUNOLOGY 19: 55 (1970). / IMMUNOLOGY (1970)
CHAO, L.P., LOCALIZATION OF ACTIVE SITE THROUGH CHEMICAL MODIFICATION OF ENCEPHALITOGENIC PROTEIN, JOURNAL OF BIOLOGICAL CHEMISTRY 245: 6397 (1970). (10.1016/S0021-9258(18)62623-7) / JOURNAL OF BIOLOGICAL CHEMISTRY (1970)
CHOU, F. C.-H., INCOMPLETE DEBLOCKING AS A CAUSE OF FAILURE SEQUENCE IN SOLID PHASE PEPTIDE SYNTHESIS, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 93: 267 (1971). (10.1021/ja00730a054) / JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (1971)
Chou F. C.-H. Abstracts 160th National Meeting of the American Chemical Society (1970).
Dayhoff M. O. Atlas of Protein Sequence and Structure 4 (1969).
EYLAR, E.H., ALLERGIC ENCEPHALOMYELITIS - CLEAVAGE OF C-TRYPTOPHYL BOND IN ENCEPHALITOGENIC BASIC PROTEINFROM BOVINE MYELIN, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 131: 215 (1969). (10.1016/0003-9861(69)90124-6) / ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (1969)
Eylar, E. H., Abstracts, Second National Meeting of the American Society for Neurochemistry: 53 (1969). / Abstracts, Second National Meeting of the American Society for Neurochemistry (1969)
Eylar, E. H., Abstracts, Second National Meeting of the American Society for Neurochemistry: 37 (1971). / Abstracts, Second National Meeting of the American Society for Neurochemistry (1971)
HASHIM, G, ALLERGIC ENCEPHALOMYELITIS . ISOLATION AND CHARACTERIZATION OF ENCEPHALITOGENIC PEPTIDES FROM BASIC PROTEIN OF BOVINE SPINAL CORD, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 129: 645 (1969). (10.1016/0003-9861(69)90225-2) / ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (1969)
KIBLER, R.F., ISOLATION AND PROPERTIES OF AN ENCEPHALITOGENIC PROTEIN FROM BOVINE RABBIT AND HUMAN CENTRAL NERVOUS SYSTEM TISSUE, JOURNAL OF BIOLOGICAL CHEMISTRY 243: 281 (1968). (10.1016/S0021-9258(18)99290-2) / JOURNAL OF BIOLOGICAL CHEMISTRY (1968)
10.1126/science.164.3879.577
KIES M PERSONAL COMMUNICATION.
PABST, H, FED P FED AM SOC EXP 29: 622 (1970). / FED P FED AM SOC EXP (1970)
Shapira, R., Journal of Biological Chemistry 246: 4630 (1971). (10.1016/S0021-9258(18)62056-3) / Journal of Biological Chemistry (1971)
Shapira, R., Abstracts, Second National Meeting of the American Society for Neurochemistry: 106 (1971). / Abstracts, Second National Meeting of the American Society for Neurochemistry (1971)
WESTALL, F.C., ESSENTIAL CHEMICAL REQUIREMENTS FOR INDUCTION OF ALLERGIC ENCEPHALOMYELITIS, NATURE 229: 22 (1971). (10.1038/229022a0) / NATURE (1971)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 9:17 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 9:24 a.m.)
Indexed	1 year, 7 months ago (Jan. 12, 2024, 10:40 a.m.)
Issued	54 years ago (Aug. 20, 1971)
Published	54 years ago (Aug. 20, 1971)
Published Print	54 years ago (Aug. 20, 1971)

Funders 0

None

BibTeX

@article{Shapira_1971, title={Biological Activity and Synthesis of an Encephalitogenic Determinant}, volume={173}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.173.3998.736}, DOI={10.1126/science.173.3998.736}, number={3998}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Shapira, R. and Chou, F. C-H. and McKneally, S. and Urban, E. and Kibler, R. F.}, year={1971}, month=aug, pages={736–738} }

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