DOI: 10.1126/science.173.3996.537. Free Radical Inhibitory Effect of Some Anticancer Compounds

Free Radical Inhibitory Effect of Some Anticancer Compounds

10.1126/science.173.3996.537

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Conventional tests for polymerization initiated by free radicals indicate that alkylating agents vary in free radical inhibitory activity from negligible to moderately strong; antimetabolites from negligible to weak; hormones, steroids, and phenolics from very weak to very strong; and antibiotics from moderate to very strong. Vitamins A and C and copper, which potentiate the biological activity of some anticancer compounds, are relatively strong free radical inhibitors.

Bibliography

Georgieff, K. K. (1971). Free Radical Inhibitory Effect of Some Anticancer Compounds. Science, 173(3996), 537â539.

Authors 1

K. K. Georgieff (first)

References 35 Referenced 30

BODKHE, R.R., ANTISEPTIC 62: 669 (1965). / ANTISEPTIC (1965)
BORG, D.C., TRANSIENT FREE RADICAL FORMS OF HORMONES - EPR SPECTRA FROM CATECHOLAMINES AND ADRENOCHROME, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 53: 633 (1965). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1965)
BORG, D.C., TRANSIENT FREE RADICAL FORMS OF HORMONES - EPR SPECTRA FROM IODOTHYRONINES INDOLES ESTROGENS AND INSULIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 53: 829 (1965). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1965)
CAPPUCCINO, J.G., EFFECT OF COPPER AND OTHER METAL IONS ON ANTITUMOR ACTIVITY OF PYRUVALDEHYDE BIS(THIOSEMICARBAZONE), CANCER RESEARCH 27: 968 (1967). / CANCER RESEARCH (1967)
CHANG, S.Y., YAO HSUEH HSUEH PAO 10: 594 (1963). / YAO HSUEH HSUEH PAO (1963)
CHERNOV, V.A., VOPROSY ONKOLOGII 8: 24 (1962). / VOPROSY ONKOLOGII (1962)
COMMONER, B, ELECTRON-SPIN RESONANCE STUDIES OF FREE-RADICAL INTERMEDIATES IN OXIDATION-REDUCTION ENZYME SYSTEMS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 44: 1099 (1958). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1958)
10.1126/science.126.3263.57
CRIM, J.A., EFFECT OF B VITAMIN AND PROTEIN INTAKE OF RAT ON ANTITUMOR ACTIVITY OF 3-ETHOXY-2-OXOBUTYRALDEHYDE BIS(THIOSEMICARBAZONE), CANCER RESEARCH 27: 1109 (1967). / CANCER RESEARCH (1967)
CRIM, J.A., ANTITUMOR ACTIVITY OF CU(2)KTS COPPER(2) CHELATE OF 3-ETHYOXY-2-OXOBUTYRALDEHYDE BIS(THIOSEMICARBAZONE), CANCER RESEARCH 27: 1278 (1967). / CANCER RESEARCH (1967)
EMANUEL, N. M., ACTA UNIO INTERNATIONALIS CONTRA CANCRUM 20: 103 (1964). / ACTA UNIO INTERNATIONALIS CONTRA CANCRUM (1964)
EMANUEL, N. M., DOKLADY AKADEMII NAUK SSSR 130: 221 (1960). / DOKLADY AKADEMII NAUK SSSR (1960)
EMANUEL, N. M., DOKLADY AKADEMII NAUK SSSR 130: 453 (1960). / DOKLADY AKADEMII NAUK SSSR (1960)
Emanuel, N. M., Proceedings of the 5th International Congress on Biochemistry 4: 58 (1961). / Proceedings of the 5th International Congress on Biochemistry (1961)
GEMANT, A, GRACE HOSPITAL BULLETIN 43 1: 3 (1965). / GRACE HOSPITAL BULLETIN (1965)
GEORGIEFF, K.K., J APPL POLYM SCI 5: 212 (1961). (10.1002/app.1961.070051414) / J APPL POLYM SCI (1961)
GEORGIEFF, K.K., J APPL POLYMER SCI 8: 889 (1964). (10.1002/app.1964.070080228) / J APPL POLYMER SCI (1964)
GEORGIEFF, K.K., RELATIVE INHIBITORY EFFECT OF VARIOUS COMPOUNDS ON RATE OF POLYMERIZATION OF VINYL ACETATE .3. EFFECT OF COMPOUNDS OF VARIOUS CLASSES, JOURNAL OF APPLIED POLYMER SCIENCE 14: 1907 (1970). (10.1002/app.1970.070140723) / JOURNAL OF APPLIED POLYMER SCIENCE (1970)
HARMAN, D, JOURNALS OF GERONTOLOGY 23: 476 (1968). (10.1093/geronj/23.4.476) / JOURNALS OF GERONTOLOGY (1968)
HILL, R.B., EFFECT OF HYDROXYUREA ANALOGUES IN REGENERATING RAT LIVER, EXPERIMENTAL AND MOLECULAR PATHOLOGY 9: 71 (1968). (10.1016/0014-4800(68)90051-8) / EXPERIMENTAL AND MOLECULAR PATHOLOGY (1968)
Knock, F. E., Anticancer Agents: 109 (1967). / Anticancer Agents (1967)
Knock, F. E., Anticancer Agents: 172 (1967). / Anticancer Agents (1967)
Knock, F. E., Anticancer Agents: 192 (1967). / Anticancer Agents (1967)
Knock, F. E., Anticancer Agents: 206 (1967). / Anticancer Agents (1967)
Knock, F. E., Anticancer Agents: 209 (1967). / Anticancer Agents (1967)
NAGATA, C, ELECTRON SPIN RESONANCE STUDY ON FREE RADICALS PRODUCED FROM 4-HYDROXYAMINOQUINOLINE 1-OXIDE AND ITS SIGNIFICANCE IN CARCINOGENESIS, GANN 57: 323 (1966). / GANN (1966)
NAGATA, C, FREE RADICAL PRODUCED BY INTERACTION OF AROMATIC HYDROCARBONS WITH TISSUE COMPONENTS, GANN 57: 437 (1966). / GANN (1966)
NAGATA, C, ELECTRON SPIN RESONANCE STUDY ON INTERACTION BETWEEN CHEMICAL CARCINOGENS AND TISSUE COMPONENTS .2. FREE RADICAL PRODUCED BY STIRRING AROMATIC HYDROCARBONS WITH TISSUE COMPONENTS SUCH AS SKIN HOMOGENATES OR PROTEINS, GANN 58: 493 (1967). / GANN (1967)
NAGATA, C, ELECTRON SPIN RESONANCE STUDY ON INTERACTION BETWEEN CHEMICAL CARCINOGENS AND TISSUE COMPONENTS .3. DETERMINATION OF STRUCTURE OF FREE RADICAL PRODUCED EITHER BY STIRRING 3,4-BENZOPYRENE WITH ALBUMIN OR INCUBATING IT WITH LIVER HOMOGENATES, GANN 59: 289 (1968). / GANN (1968)
PETERING, H.G., EFFECT OF DIETARY MINERAL SUPPLEMENTS OF RAT ON ANTITUMOR ACTIVITY OF 3-ETHOXY-2-OXOBUTYRALDEHYDE BIS(THIOSEMICARBAZONE), CANCER RESEARCH 27: 1115 (1967). / CANCER RESEARCH (1967)
SVEC, J, ACTION OF SOME CYTOSTATICS ON HEXOSE MONOPHOSPHATE SHUNT AND GLYCOLYSIS IN EXPERIMENTAL RAT TUMOURS, BIOCHEMICAL PHARMACOLOGY 13: 1663 (1964). (10.1016/0006-2952(64)90220-5) / BIOCHEMICAL PHARMACOLOGY (1964)
TSETLIN, A.L., RAST RESURSY 1: 507 (1965). / RAST RESURSY (1965)
VITHAYATHIL, A.J., CHANGES IN ELECTRON SPIN RESONANCE SIGNALS OF RAT LIVER DURING CHEMICAL CARCINOGENESIS, NATURE 207: 1246 (1965). (10.1038/2071246a0) / NATURE (1965)
WYARD, S.J., ELECTRON SPIN RESONANCE SPECTROSCOPY OF ANIMAL TISSUES, PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL AND PHYSICAL SCIENCES 302: 355 (1968). / PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL AND PHYSICAL SCIENCES (1968)
YATES, W.R., INHIBITION OF OXIDATION AND POLYMERIZATION OF METHYL METHACRYLATE .2. EFFECT OF AROMATIC AMINES, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 87: 710 (1965). (10.1021/ja01082a005) / JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (1965)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 9:17 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 11:40 a.m.)
Indexed	1 year, 7 months ago (Jan. 11, 2024, 7:03 p.m.)
Issued	54 years ago (Aug. 6, 1971)
Published	54 years ago (Aug. 6, 1971)
Published Print	54 years ago (Aug. 6, 1971)

Funders 0

None

BibTeX

@article{Georgieff_1971, title={Free Radical Inhibitory Effect of Some Anticancer Compounds}, volume={173}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.173.3996.537}, DOI={10.1126/science.173.3996.537}, number={3996}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Georgieff, K. K.}, year={1971}, month=aug, pages={537–539} }

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