DOI: 10.1126/science.173.3991.65. Hypolipidemia in a Mutant Strain of "Acatalasemic" Mice

Hypolipidemia in a Mutant Strain of "Acatalasemic" Mice

10.1126/science.173.3991.65

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Mutant "acatalasemic" mice have an unstable catalase in hepatic and renal peroxisomes that is readily degraded, apparently into peroxidase subunits. The hypothesis that an in situ cataloperoxidase would affect serum lipids was tested in these mutants and serum triglycerides and cholesterol were found to be significantly lower than in the wild strain. This finding is in accordance with reports that a hypolipidemic response to the injection of peroxidase subunits of hepatic catalase occurs in humans and rabbits.

Bibliography

Goldfischer, S., Roheim, P. S., Edelstein, D., & Essner, E. (1971). Hypolipidemia in a Mutant Strain of âAcatalasemicâ Mice. Science, 173(3991), 65â66.

Authors 4

Sidney Goldfischer (first)
Paul S. Roheim (additional)
Diane Edelstein (additional)
Edward Essner (additional)

References 25 Referenced 23

Abell, L. L., Journal of Biological Chemistry 195: 357 (1952). (10.1016/S0021-9258(19)50907-3) / Journal of Biological Chemistry (1952)
AEBI, H, ACTIVITY AND STABILITY OF CATALASE IN BLOOD AND TISSUES OF NORMAL AND ACATALASEMIC MICE, BIOCHEMICAL GENETICS 2: 245 (1968). (10.1007/BF01474764) / BIOCHEMICAL GENETICS (1968)
CARAVACA, J, INHIBITION OF SQUALENE AND CHOLESTEROL BIOSYNTHESIS BY HEPATOCATALASE (CAPERASE), BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 10: 189 (1963). (10.1016/0006-291X(63)90049-4) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1963)
CARAVACA, J, ISOLATION + PROPERTIES OF ACTIVE PEROXIDASE FROM HEPATOCATALASE, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 16: 528 (1964). (10.1016/0006-291X(64)90187-1) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1964)
10.1126/science.155.3767.1284
de DUVE C. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 168 2 (1969). (10.1111/j.1749-6632.1969.tb43110.x)
de DUVE, C., PHYSIOL REV 46: 323 (1966). (10.1152/physrev.1966.46.2.323) / PHYSIOL REV (1966)
FEINSTEIN, R.N., A CATALASEMIA IN MOUSE AND OTHER SPECIES, BIOCHEMICAL GENETICS 4: 135 (1970). (10.1007/BF00484026) / BIOCHEMICAL GENETICS (1970)
GERHARDT, B.P., DEVELOPMENTAL STUDIES ON GLYOXYSOMES IN RICINUS ENDOSPERM, JOURNAL OF CELL BIOLOGY 44: 94 (1970). (10.1083/jcb.44.1.94) / JOURNAL OF CELL BIOLOGY (1970)
GOLDFISCHER, S, FURTHER OBSERVATIONS ON PEROXIDATIC ACTIVITIES OF MICROBODIES (PEROXISOMES), JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 17: 681 (1969). (10.1177/17.10.681) / JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (1969)
GOLDFISCHER, S, PEROXIDASE ACTIVITY IN PEROXISOMES (MICROBODIES) OF ACATALASEMIC MICE, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 18: 482 (1970). (10.1177/18.7.482) / JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (1970)
HESS, R, NATURE OF HEPATOMEGALIC EFFECT PRODUCED BY ETHYL-CHLOROPHENOXY-ISOBUTYRATE IN RAT, NATURE 208: 856 (1965). (10.1038/208856a0) / NATURE (1965)
INADA, U, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 93: 30 (1961). (10.1016/0003-9861(61)90311-3) / ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (1961)
NOVIKOFF, A.B., VISUALIZATION OF PEROXISOMES (MICROBODIES) AND MITOCHONDRIA WITH DIAMINOBENZIDINE, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 17: 675 (1969). (10.1177/17.10.675) / JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (1969)
POULE, B, J CELL BIOL 41: 536 (1969). (10.1083/jcb.41.2.536) / J CELL BIOL (1969)
PRICE, V.E., KINETICS OF CATALASE SYNTHESIS AND DESTRUCTION IN VIVO, JOURNAL OF BIOLOGICAL CHEMISTRY 237: 3468 (1962). (10.1016/S0021-9258(19)70841-2) / JOURNAL OF BIOLOGICAL CHEMISTRY (1962)
Puig-Muset P. International Symposium on Drugs Affecting Lipid Metabolism (1960).
ROHEIM, P.S., JOURNAL OF LIPID RESEARCH 12: 76 (1971). (10.1016/S0022-2275(20)39549-3) / JOURNAL OF LIPID RESEARCH (1971)
SVOBODA, D, MICROBODIES IN EXPERIMENTALLY ALTERED CELLS .2. RELATIONSHIP OF MICROBODY PROLIFERATION TO ENDOCRINE GLANDS, JOURNAL OF CELL BIOLOGY 40: 734 (1969). (10.1083/jcb.40.3.734) / JOURNAL OF CELL BIOLOGY (1969)
SVOBODA, D.J., RESPONSE OF HEPATIC MICROBODIES TO A HYPOLIPIDEMIC AGENT ETHYL CHLOROPHENOXYISOBUTYRATE (CPIB), JOURNAL OF CELL BIOLOGY 30: 442 (1966). (10.1083/jcb.30.2.442) / JOURNAL OF CELL BIOLOGY (1966)
TAKAHARA, S, HYPOCATALASEMIA - A NEW GENETIC CARRIER STATE, JOURNAL OF CLINICAL INVESTIGATION 39: 610 (1960). (10.1172/JCI104075) / JOURNAL OF CLINICAL INVESTIGATION (1960)
TANFORD, C, DISSOCIATION OF CATALASE INTO SUBUNITS, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 84: 1892 (1962). (10.1021/ja00869a025) / JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (1962)
VANHANDEL, E, SUGGESTED MODIFICAATIONS OF MICRO DETERMINATION OF TRIGLYCERIDES, CLINICAL CHEMISTRY 7: 249 (1961). (10.1093/clinchem/7.3.249) / CLINICAL CHEMISTRY (1961)
VIGIL, E.L., CYTOCHEMICAL AND DEVELOPMENTAL CHANGES IN MICROBODIES (GLYOXYSOMES) AND RELATED ORGANELLES OF CASTOR BEAN ENDOSPERM, JOURNAL OF CELL BIOLOGY 46: 435 (1970). (10.1083/jcb.46.3.435) / JOURNAL OF CELL BIOLOGY (1970)
ZILBERSMIT, D.B., J LAB CLIN MED 50: 152 (1957). / J LAB CLIN MED (1957)

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 9:17 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 11:42 a.m.)
Indexed	1 year, 7 months ago (Jan. 11, 2024, 7:03 p.m.)
Issued	54 years, 2 months ago (July 2, 1971)
Published	54 years, 2 months ago (July 2, 1971)
Published Print	54 years, 2 months ago (July 2, 1971)

Funders 0

None

BibTeX

@article{Goldfischer_1971, title={Hypolipidemia in a Mutant Strain of “Acatalasemic” Mice}, volume={173}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.173.3991.65}, DOI={10.1126/science.173.3991.65}, number={3991}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Goldfischer, Sidney and Roheim, Paul S. and Edelstein, Diane and Essner, Edward}, year={1971}, month=jul, pages={65–66} }

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