DOI: 10.1126/science.1720570. Characterization of a Zinc Finger Gene Disrupted by the t(15;17) in Acute Promyelocytic Leukemia

Characterization of a Zinc Finger Gene Disrupted by the t(15;17) in Acute Promyelocytic Leukemia

10.1126/science.1720570

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The translocation t(15;17) associated with acute promyelocytic leukemia results in the fusion of the retinoic acid receptor alpha ( RARA ) gene to the PML gene. Characterization of PML revealed that it is a putative zinc finger protein and potential transcription factor that is commonly expressed, with at least three major transcription products. PML breakpoints cluster in two regions on either side of an alternatively spliced exon. Although leukemic cells with translocations characteristically express only one fusion product, both PML / RARA (on the 15q+ derivative chromosome) and RARA / PML (on the 17q- derivative) are transcribed.

Bibliography

Goddard, A. D., Borrow, J., Freemont, P. S., & Solomon, E. (1991). Characterization of a Zinc Finger Gene Disrupted by the t(15;17) in Acute Promyelocytic Leukemia. Science, 254(5036), 1371â1374.

Authors 4

Audrey D. Goddard (first)
Julian Borrow (additional)
Paul S. Freemont (additional)
Ellen Solomon (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 11:46 a.m.)
Indexed	4 weeks, 1 day ago (Aug. 3, 2025, 6:48 p.m.)
Issued	33 years, 9 months ago (Nov. 29, 1991)
Published	33 years, 9 months ago (Nov. 29, 1991)
Published Print	33 years, 9 months ago (Nov. 29, 1991)

Funders 0

None

BibTeX

@article{Goddard_1991, title={Characterization of a Zinc Finger Gene Disrupted by the t(15;17) in Acute Promyelocytic Leukemia}, volume={254}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1720570}, DOI={10.1126/science.1720570}, number={5036}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Goddard, Audrey D. and Borrow, Julian and Freemont, Paul S. and Solomon, Ellen}, year={1991}, month=nov, pages={1371–1374} }

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