DOI: 10.1126/science.1718038. Regulation of Rransendothelial Neutrophil Migration by Endogenous Interleukin-8

Regulation of Rransendothelial Neutrophil Migration by Endogenous Interleukin-8

10.1126/science.1718038

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Movement of neutrophils from the bloodstream to inflamed tissue depends on the activation of both the neutrophil and the endothelial cell. Endothelial cells lining the postcapillary venule respond to proinflammatory mediators by expressing adhesion molecules and synthesizing a variety of neutrophil-activating factors. Endothelial cell production of a 77-amino acid variant of interleukin-8 (IL-8) was found to be a requirement for the invasion of neutrophils through a vessel wall model. IL-8 secreted by cytokine- or lipopolysaccharide-stimulated endothelial cells induced the rapid shedding of neutrophil lectin adhesion molecule-1, the up-regulation of leukocyte β 2 integrins, and the attachment and transmigration of the neutrophils. Thus, endogenous endothelial IL-8 regulates transvenular traffic during acute inflammatory responses.

Bibliography

Huber, A. R., Kunkel, S. L., Todd, R. F., & Weiss, S. J. (1991). Regulation of Rransendothelial Neutrophil Migration by Endogenous Interleukin-8. Science, 254(5028), 99â102.

Authors 4

Andreas R. Huber (first)
Steven L. Kunkel (additional)
Robert F. Todd (additional)
Stephen J. Weiss (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 9:09 a.m.)
Indexed	14 hours, 10 minutes ago (Aug. 29, 2025, 5:47 a.m.)
Issued	33 years, 10 months ago (Oct. 4, 1991)
Published	33 years, 10 months ago (Oct. 4, 1991)
Published Print	33 years, 10 months ago (Oct. 4, 1991)

Funders 0

None

BibTeX

@article{Huber_1991, title={Regulation of Rransendothelial Neutrophil Migration by Endogenous Interleukin-8}, volume={254}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1718038}, DOI={10.1126/science.1718038}, number={5028}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Huber, Andreas R. and Kunkel, Steven L. and Todd, Robert F. and Weiss, Stephen J.}, year={1991}, month=oct, pages={99–102} }

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