DOI: 10.1126/science.1708917. Presence of an SH2 Domain in the Actin-Binding Protein Tensin

Presence of an SH2 Domain in the Actin-Binding Protein Tensin

10.1126/science.1708917

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The molecular cloning of the complementary DNA coding for a 90-kilodalton fragment of tensin, an actin-binding component of focal contacts and other submembraneous cytoskeletal structures, is reported. The derived amino acid sequence revealed the presence of a Src homology 2 (SH2) domain. This domain is shared by a number of signal transduction proteins including nonreceptor tyrosine kinases such as Abl, Fps, Src, and Src family members, the transforming protein Crk, phospholipase C-γ1, PI-3 (phosphatidylinositol) kinase, and guanosine triphosphatase-activating protein (GAP). Like the SH2 domain found in Src, Crk, and Abl, the SH2 domain of tensin bound specifically to a number of phosphotyrosine-containing proteins from v-src-transformed cells. Tensin was also found to be phosphorylated on tyrosine residues. These findings suggest that by possessing both actin-binding and phosphotyrosine-binding activities and being itself a target for tyrosine kinases, tensin may link signal transduction pathways with the cytoskeleton.

Bibliography

Davis, S., Lu, M. L., Lo, S. H., Lin, S., Butler, J. A., Druker, B. J., Roberts, T. M., An, Q., & Chen, L. B. (1991). Presence of an SH2 Domain in the Actin-Binding Protein Tensin. Science, 252(5006), 712â715.

Authors 9

Samuel Davis (first)
Michael L. Lu (additional)
Su Hao Lo (additional)
Shin Lin (additional)
James A. Butler (additional)
Brian J. Druker (additional)
Thomas M. Roberts (additional)
Qi An (additional)
Lan Bo Chen (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 11:40 a.m.)
Indexed	3 months, 2 weeks ago (May 12, 2025, 10:46 a.m.)
Issued	34 years, 3 months ago (May 3, 1991)
Published	34 years, 3 months ago (May 3, 1991)
Published Print	34 years, 3 months ago (May 3, 1991)

Funders 0

None

BibTeX

@article{Davis_1991, title={Presence of an SH2 Domain in the Actin-Binding Protein Tensin}, volume={252}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1708917}, DOI={10.1126/science.1708917}, number={5006}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Davis, Samuel and Lu, Michael L. and Lo, Su Hao and Lin, Shin and Butler, James A. and Druker, Brian J. and Roberts, Thomas M. and An, Qi and Chen, Lan Bo}, year={1991}, month=may, pages={712–715} }

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