DOI: 10.1126/science.170681. Thermal Transitions in Human Plasma Low Density Lipoproteins

Thermal Transitions in Human Plasma Low Density Lipoproteins

10.1126/science.170681

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Thermal analysis of human plasma low density lipoproteins reveals a broad reversible transition encompassing body temperature. The calorimetric and x-ray scattering data identify this transition as a cooperative, liquid-crystalline to liquid phase change involving the cholesterol esters in the lipoprotein. This behavior requires the presence of a region rich in cholesterol ester within the lipoprotein.

Bibliography

Deckelbaum, R. J., Shipley, G. G., Small, D. M., Lees, R. S., & George, P. K. (1975). Thermal Transitions in Human Plasma Low Density Lipoproteins. Science, 190(4212), 392â394.

Authors 5

R. J. Deckelbaum (first)
G. G. Shipley (additional)
D. M. Small (additional)
R. S. Lees (additional)
P. K. George (additional)

References 22 Referenced 159

BOURGES, M, BIOPHYSICS OF LIPIDIC ASSOCIATIONS .2. TERNARY SYSTEMS CHOLESTEROL-LECITHIN-WATER, BIOCHIMICA ET BIOPHYSICA ACTA 137: 157 (1967). (10.1016/0005-2760(67)90019-7) / BIOCHIMICA ET BIOPHYSICA ACTA (1967)
DAVIS, G.J., MOL CRYST LIQ CRYST 10: 331 (1970). (10.1080/15421407008082819) / MOL CRYST LIQ CRYST (1970)
DOWNING, D.T., PHOTODENSITOMETRY IN THIN-LAYER CHROMATOGRAPHIC ANALYSIS OF NEUTRAL LIPIDS, JOURNAL OF CHROMATOGRAPHY 38: 91 (1968). (10.1016/0021-9673(68)85011-3) / JOURNAL OF CHROMATOGRAPHY (1968)
FOLCH, J, A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES, JOURNAL OF BIOLOGICAL CHEMISTRY 226: 497 (1957). (10.1016/S0021-9258(18)64849-5) / JOURNAL OF BIOLOGICAL CHEMISTRY (1957)
HATCH, F.T., ADV LIPID RES 6: 1 (1968). (10.1016/B978-1-4831-9942-9.50008-5) / ADV LIPID RES (1968)
JANIAK, M.J., TERNARY PHASE-DIAGRAM OF LECITHIN, CHOLESTERYL LINOLENATE AND WATER - PHASE BEHAVIOR AND STRUCTURE, JOURNAL OF MOLECULAR BIOLOGY 86: 325 (1974). (10.1016/0022-2836(74)90022-9) / JOURNAL OF MOLECULAR BIOLOGY (1974)
Klug, H. P., X-Ray Diffraction Procedures: 511 (1954). / X-Ray Diffraction Procedures (1954)
LADBROOKE, B.D., STUDIES ON LECITHIN-CHOLESTEROL-WATER INTERACTIONS BY DIFFERENTIAL SCANNING CALORIMETRY AND X-RAY DIFFRACTION, BIOCHIMICA ET BIOPHYSICA ACTA 150: 333 (1968). (10.1016/0005-2736(68)90132-6) / BIOCHIMICA ET BIOPHYSICA ACTA (1968)
LADBROOKE, B.D., THERMAL ANALYSIS OF LIPIDS, PROTEINS AND BIOLOGICAL MEMBRANES . A REVIEW AND SUMMARY OF SOME RECENT STUDIES, CHEMISTRY AND PHYSICS OF LIPIDS 3: 304 (1969). (10.1016/0009-3084(69)90040-1) / CHEMISTRY AND PHYSICS OF LIPIDS (1969)
LECUYER, H, STRUCTURE OF AQUEOUS MIXTURES OF LECITHIN AND CHOLESTEROL, JOURNAL OF MOLECULAR BIOLOGY 45: 39 (1969). (10.1016/0022-2836(69)90208-3) / JOURNAL OF MOLECULAR BIOLOGY (1969)
Lee, A. G., Methods in Membrane Biology 2: 1 (1974). / Methods in Membrane Biology (1974)
LEE, D.M., PHYSICOCHEMICAL PROPERTIES OF LOW-DENSITY LIPOPROTEINS OF NORMAL HUMAN PLASMA - EVIDENCE FOR OCCURRENCE OF LIPOPROTEIN B IN ASSOCIATED AND FREE FORMS, BIOCHEMICAL JOURNAL 137: 155 (1974). (10.1042/bj1370155) / BIOCHEMICAL JOURNAL (1974)
LEE, D.M., STUDIES OF COMPOSITION AND STRUCTURE OF PLASMA LIPOPROTEINS - ISOLATION, COMPOSITION, AND IMMUNOCHEMICAL CHARACTERIZATION OF LOW DENSITY LIPOPROTEIN SUBFRACTIONS OF HUMAN PLASMA, BIOCHEMISTRY 9: 2244 (1970). (10.1021/bi00813a004) / BIOCHEMISTRY (1970)
LOOMIS, C.R., BINARY PHASE-DIAGRAM OF LECITHIN AND CHOLESTERYL LINOLENATE, JOURNAL OF MOLECULAR BIOLOGY 86: 309 (1974). (10.1016/0022-2836(74)90021-7) / JOURNAL OF MOLECULAR BIOLOGY (1974)
10.1016/S0021-9258(19)52451-6
MATEU, L, STRUCTURE OF HUMAN SERUM LOW-DENSITY LIPOPROTEIN, JOURNAL OF MOLECULAR BIOLOGY 70: 105 (1972). (10.1016/0022-2836(72)90166-0) / JOURNAL OF MOLECULAR BIOLOGY (1972)
SHIPLEY G.G. UNPUBLISHED OBSERVATIONS.
Small, D. M., Liquid Crystals and Ordered Fluids: 11 (1974). / Liquid Crystals and Ordered Fluids (1974)
Small, D. M., Surface Chemistry of Biological Systems: 55 (1970). / Surface Chemistry of Biological Systems (1970)
SMALL D.M. UNPUBLISHED WORK.
Steim, J. M., Molecular Association in Biological and Related Systems: 259 (1968). / Molecular Association in Biological and Related Systems (1968)
STURTEVANT, J.M., SOME APPLICATIONS OF CALORIMETRY IN BIOCHEMISTRY AND BIOLOGY, ANNUAL REVIEW OF BIOPHYSICS AND BIOENGINEERING 3: 35 (1974). (10.1146/annurev.bb.03.060174.000343) / ANNUAL REVIEW OF BIOPHYSICS AND BIOENGINEERING (1974)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 11:11 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 11:14 a.m.)
Indexed	19 hours, 52 minutes ago (Sept. 4, 2025, 9:16 a.m.)
Issued	49 years, 10 months ago (Oct. 24, 1975)
Published	49 years, 10 months ago (Oct. 24, 1975)
Published Print	49 years, 10 months ago (Oct. 24, 1975)

Funders 0

None

BibTeX

@article{Deckelbaum_1975, title={Thermal Transitions in Human Plasma Low Density Lipoproteins}, volume={190}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.170681}, DOI={10.1126/science.170681}, number={4212}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Deckelbaum, R. J. and Shipley, G. G. and Small, D. M. and Lees, R. S. and George, P. K.}, year={1975}, month=oct, pages={392–394} }

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