DOI: 10.1126/science.1702903. Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn

Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn

10.1126/science.1702903

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Antigen is thought to cross-link membrane-bound immunoglobulins (Igs) of B cells, causing proliferation and differentiation or the inhibition of growth. Protein tyrosine kinases are probably involved in signal transduction for cell proliferation and differentiation. The Src-like protein tyrosine kinase Lyn is expressed preferentially in B cells. The Lyn protein and its kinase activity could be coimmunoprecipitated with IgM from detergent lysates. Cross-linking of membrane-bound IgM induced a rapid increase in tyrosine phosphorylation of at least ten distinct proteins of B cells. Thus, Lyn is physically associated with membrane-bound IgM, and is suggested to participate in antigen-mediated signal transduction.

Bibliography

Yamanashi, Y., Kakiuchi, T., Mizuguchi, J., Yamamoto, T., & Toyoshima, K. (1991). Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn. Science, 251(4990), 192â194.

Authors 5

Yuji Yamanashi (first)
Terutaka Kakiuchi (additional)
Junichiro Mizuguchi (additional)
Tadashi Yamamoto (additional)
Kumao Toyoshima (additional)

References 39 Referenced 313

BARBER, E.K., THE CD4 AND CD8 ANTIGENS ARE COUPLED TO A PROTEIN-TYROSINE KINASE (P56LCK) THAT PHOSPHORYLATES THE CD3 COMPLEX, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 3277 (1989). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1989)
BIJSTERBOSCH, M.K., LYMPHOCYTE-B RECEPTORS AND POLYPHOSPHOINOSITIDE DEGRADATION, CELL 41: 999 (1985). (10.1016/S0092-8674(85)80080-5) / CELL (1985)
BOYD, A.W., THE REGULATION OF GROWTH AND DIFFERENTIATION OF A MURINE B-CELL LYMPHOMA .2. THE INHIBITION OF WEHI-231 BY ANTI-IMMUNOGLOBULIN ANTIBODIES, JOURNAL OF IMMUNOLOGY 126: 2466 (1981). (10.4049/jimmunol.126.6.2466) / JOURNAL OF IMMUNOLOGY (1981)
CAMPBELL, K.S., B-LYMPHOCYTE ANTIGEN RECEPTORS (MLG) ARE NON-COVALENTLY ASSOCIATED WITH A DISULFIDE LINKED, INDUCIBLY PHOSPHORYLATED GLYCOPROTEIN COMPLEX, EMBO JOURNAL 9: 441 (1990). (10.1002/j.1460-2075.1990.tb08129.x) / EMBO JOURNAL (1990)
CAMPBELL, M.A., PROTEIN TYROSINE PHOSPHORYLATION IN INDUCED IN MURINE LYMPHOCYTES-B IN RESPONSE TO STIMULATION WITH ANTIIMMUNOGLOBULIN, EMBO JOURNAL 9: 2125 (1990). (10.1002/j.1460-2075.1990.tb07381.x) / EMBO JOURNAL (1990)
CHENG, H.L., STRUCTURE OF GENES FOR MEMBRANE AND SECRETED MURINE IGD HEAVY-CHAINS, NATURE 296: 410 (1982). (10.1038/296410a0) / NATURE (1982)
Cooper, J. A., Peptides and Protein Phosphorylation: 85 (1990). / Peptides and Protein Phosphorylation (1990)
DEFRANCO, A.L., FREQUENCY OF LYMPHOCYTES-B RESPONSIVE TO ANTI-IMMUNOGLOBULIN, JOURNAL OF EXPERIMENTAL MEDICINE 155: 1523 (1982). (10.1084/jem.155.5.1523) / JOURNAL OF EXPERIMENTAL MEDICINE (1982)
10.1126/science.2404338
GOLD, M.R., INVOLVEMENT OF A GUANINE NUCLEOTIDE-BINDING COMPONENT IN MEMBRANE IGM-STIMULATED PHOSPHOINOSITIDE BREAKDOWN, JOURNAL OF IMMUNOLOGY 139: 3604 (1987). (10.4049/jimmunol.139.11.3604) / JOURNAL OF IMMUNOLOGY (1987)
GOLD, M.R., STIMULATION OF PROTEIN TYROSINE PHOSPHORYLATION BY THE LYMPHOCYTE-B ANTIGEN RECEPTOR, NATURE 345: 810 (1990). (10.1038/345810a0) / NATURE (1990)
GOODNOW, C.C., NATURE 342: 385 (1989). (10.1038/342385a0) / NATURE (1989)
GRUBER, M.F., J IMMUNOL 142: 1444 (1989). (10.4049/jimmunol.142.5.1444) / J IMMUNOL (1989)
GRUPP, S.A., INCREASED PHOSPHATIDYLINOSITOL METABOLISM IS AN IMPORTANT BUT NOT AN OBLIGATORY EARLY EVENT IN LYMPHOCYTE-B ACTIVATION, JOURNAL OF IMMUNOLOGY 134: 4087 (1985). (10.4049/jimmunol.134.6.4087) / JOURNAL OF IMMUNOLOGY (1985)
HAMAGUCHI, M, PHOSPHORYLATION OF CELLULAR PROTEINS IN ROUS-SARCOMA VIRUS-INFECTED CELLS - ANALYSIS BY USE OF ANTI-PHOSPHOTYROSINE ANTIBODIES, MOLECULAR AND CELLULAR BIOLOGY 8: 3035 (1988). / MOLECULAR AND CELLULAR BIOLOGY (1988)
HARNETT, M.M., G-PROTEIN COUPLING OF ANTIGEN RECEPTOR-STIMULATED POLYPHOSPHOINOSITIDE HYDROLYSIS IN B-CELLS, JOURNAL OF IMMUNOLOGY 140: 3135 (1988). (10.4049/jimmunol.140.9.3135) / JOURNAL OF IMMUNOLOGY (1988)
HOMBACH, J, MOLECULAR-COMPONENTS OF THE B-CELL ANTIGEN RECEPTOR COMPLEX OF THE IGM CLASS, NATURE 343: 760 (1990). (10.1038/343760a0) / NATURE (1990)
HUNTER, T, PROTEIN-TYROSINE KINASES, ANNUAL REVIEW OF BIOCHEMISTRY 54: 897 (1985). (10.1146/annurev.bi.54.070185.004341) / ANNUAL REVIEW OF BIOCHEMISTRY (1985)
KIM, K.J., ESTABLISHMENT AND CHARACTERIZATION OF BALB-C LYMPHOMA LINES WITH B-CELL PROPERTIES, JOURNAL OF IMMUNOLOGY 122: 549 (1979). (10.4049/jimmunol.122.2.549) / JOURNAL OF IMMUNOLOGY (1979)
KLAUS, GGB, RECEPTOR SIGNALING AND CROSSTALK IN LYMPHOCYTES-B, IMMUNOLOGICAL REVIEWS 99: 19 (1987). (10.1111/j.1600-065X.1987.tb01170.x) / IMMUNOLOGICAL REVIEWS (1987)
MIZUGUCHI, J, MEMBRANE IGM, IGD, AND IGG ACT AS SIGNAL TRANSMISSION MOLECULES IN A SERIES OF B-LYMPHOMAS, JOURNAL OF IMMUNOLOGY 137: 2162 (1986). (10.4049/jimmunol.137.7.2162) / JOURNAL OF IMMUNOLOGY (1986)
MONROE, J.G., INVOLVEMENT OF A SPECIFIC GUANINE-NUCLEOTIDE BINDING-PROTEIN IN RECEPTOR IMMUNOGLOBULIN STIMULATED INOSITOL PHOSPHOLIPID HYDROLYSIS, BIOCHIMICA ET BIOPHYSICA ACTA 1013: 273 (1989). (10.1016/0167-4889(89)90146-8) / BIOCHIMICA ET BIOPHYSICA ACTA (1989)
NOSSAL, G. J. V., ANNUAL REVIEW OF IMMUNOLOGY 1: 33 (1989). / ANNUAL REVIEW OF IMMUNOLOGY (1989)
OETTGEN, H.C., A T3-LIKE PROTEIN COMPLEX ASSOCIATED WITH THE ANTIGEN RECEPTOR ON MURINE T-CELLS, NATURE 320: 272 (1986). (10.1038/320272a0) / NATURE (1986)
ROGERS, J, 2 MESSENGER-RNAS WITH DIFFERENT 3' ENDS ENCODE MEMBRANE-BOUND AND SECRETED FORMS OF IMMUNOGLOBULIN-MU CHAIN, CELL 20: 303 (1980). (10.1016/0092-8674(80)90616-9) / CELL (1980)
RUDD, C.E., THE CD4 RECEPTOR IS COMPLEXED IN DETERGENT LYSATES TO A PROTEIN-TYROSINE KINASE (PP58) FROM HUMAN LYMPHOCYTES-T, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 5190 (1988). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1988)
SAKAGUCHI, N, LYMPHOCYTE-B LINEAGE-RESTRICTED EXPRESSION OF MB-1, A GENE WITH CD3-LIKE STRUCTURAL-PROPERTIES, EMBO JOURNAL 7: 3457 (1988). (10.1002/j.1460-2075.1988.tb03220.x) / EMBO JOURNAL (1988)
Semba, K., Genes and Cancer: 73 (1990). / Genes and Cancer (1990)
TONKS, N.K., BIOCHEMISTRY-US 27: 8695 (1988). (10.1021/bi00424a001) / BIOCHEMISTRY-US (1988)
TYLER, B.M., MESSENGER-RNA FOR SURFACE-IMMUNOGLOBULIN GAMMA-CHAINS ENCODES A HIGHLY CONSERVED TRANSMEMBRANE SEQUENCE AND A 28-RESIDUE INTRACELLULAR DOMAIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 2008 (1982). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1982)
10.1016/0092-8674(90)90801-K
VASILOV, R.G., BIOSYNTHESIS OF MURINE IMMUNOGLOBULIN-D - HETEROGENEITY OF GLYCOSYLATION, EUROPEAN JOURNAL OF IMMUNOLOGY 12: 804 (1982). (10.1002/eji.1830121003) / EUROPEAN JOURNAL OF IMMUNOLOGY (1982)
10.1016/0092-8674(88)90053-0
VEILLETTE, A, SIGNAL TRANSDUCTION THROUGH THE CD4 RECEPTOR INVOLVES THE ACTIVATION OF THE INTERNAL MEMBRANE TYROSINE-PROTEIN KINASE P56LCK, NATURE 338: 257 (1989). (10.1038/338257a0) / NATURE (1989)
WIENANDS, J, MOLECULAR-COMPONENTS OF THE B-CELL ANTIGEN RECEPTOR COMPLEX OF CLASS IGD DIFFER PARTLY FROM THOSE OF IGM, EMBO JOURNAL 9: 449 (1990). (10.1002/j.1460-2075.1990.tb08130.x) / EMBO JOURNAL (1990)
YAMANASHI, Y, THE YES-RELATED CELLULAR GENE LYN ENCODES A POSSIBLE TYROSINE KINASE SIMILAR TO P56LCK, MOLECULAR AND CELLULAR BIOLOGY 7: 237 (1987). / MOLECULAR AND CELLULAR BIOLOGY (1987)
YAMANASHI, Y, SELECTIVE EXPRESSION OF A PROTEIN-TYROSINE KINASE, P56LYN, IN HEMATOPOIETIC-CELLS AND ASSOCIATION WITH PRODUCTION OF HUMAN T-CELL LYMPHOTROPHIC VIRUS TYPE-I, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 6538 (1989). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1989)
YAMANASHI Y unpublished data.
YAMAWAKIKATAOKA, Y, NUCLEOTIDE-SEQUENCES OF GENE SEGMENTS ENCODING MEMBRANE DOMAINS OF IMMUNOGLOBULIN GAMMA-CHAINS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 2623 (1982). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1982)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 10:14 a.m.)
Indexed	4 months, 4 weeks ago (March 30, 2025, 5:47 a.m.)
Issued	34 years, 7 months ago (Jan. 11, 1991)
Published	34 years, 7 months ago (Jan. 11, 1991)
Published Print	34 years, 7 months ago (Jan. 11, 1991)

Funders 0

None

BibTeX

@article{Yamanashi_1991, title={Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn}, volume={251}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1702903}, DOI={10.1126/science.1702903}, number={4990}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Yamanashi, Yuji and Kakiuchi, Terutaka and Mizuguchi, Junichiro and Yamamoto, Tadashi and Toyoshima, Kumao}, year={1991}, month=jan, pages={192–194} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        3,
        30
      ]
    ],
    "date-time": "2025-03-30T09:47:45Z",
    "timestamp": 1743328065802
  },
  "reference-count": 39,
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "issue": "4990",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1991,
        1,
        11
      ]
    ]
  },
  "abstract": "<jats:p>Antigen is thought to cross-link membrane-bound immunoglobulins (Igs) of B cells, causing proliferation and differentiation or the inhibition of growth. Protein tyrosine kinases are probably involved in signal transduction for cell proliferation and differentiation. The Src-like protein tyrosine kinase Lyn is expressed preferentially in B cells. The Lyn protein and its kinase activity could be coimmunoprecipitated with IgM from detergent lysates. Cross-linking of membrane-bound IgM induced a rapid increase in tyrosine phosphorylation of at least ten distinct proteins of B cells. Thus, Lyn is physically associated with membrane-bound IgM, and is suggested to participate in antigen-mediated signal transduction.</jats:p>",
  "DOI": "10.1126/science.1702903",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        10,
        5
      ]
    ],
    "date-time": "2006-10-05T22:10:16Z",
    "timestamp": 1160086216000
  },
  "page": "192-194",
  "source": "Crossref",
  "is-referenced-by-count": 313,
  "title": "Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn",
  "prefix": "10.1126",
  "volume": "251",
  "author": [
    {
      "given": "Yuji",
      "family": "Yamanashi",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Oncology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108, Japan."
        }
      ]
    },
    {
      "given": "Terutaka",
      "family": "Kakiuchi",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Allergology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108, Japan."
        }
      ]
    },
    {
      "given": "Junichiro",
      "family": "Mizuguchi",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Applied Immunology, National Institute of Health, Shinagawa-ku, Tokyo 141, Japan."
        }
      ]
    },
    {
      "given": "Tadashi",
      "family": "Yamamoto",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Oncology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108, Japan."
        }
      ]
    },
    {
      "given": "Kumao",
      "family": "Toyoshima",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Oncology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108, Japan."
        }
      ]
    }
  ],
  "member": "221",
  "reference": [
    {
      "key": "e_1_2_1_1_1",
      "first-page": "3277",
      "volume": "86",
      "year": "1989",
      "unstructured": "BARBER, E.K., THE CD4 AND CD8 ANTIGENS ARE COUPLED TO A PROTEIN-TYROSINE KINASE (P56LCK) THAT PHOSPHORYLATES THE CD3 COMPLEX, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 3277 (1989).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_2_1",
      "doi-asserted-by": "crossref",
      "first-page": "999",
      "DOI": "10.1016/S0092-8674(85)80080-5",
      "volume": "41",
      "year": "1985",
      "unstructured": "BIJSTERBOSCH, M.K., LYMPHOCYTE-B RECEPTORS AND POLYPHOSPHOINOSITIDE DEGRADATION, CELL 41: 999 (1985).",
      "journal-title": "CELL"
    },
    {
      "key": "e_1_2_1_3_1",
      "doi-asserted-by": "crossref",
      "first-page": "2466",
      "DOI": "10.4049/jimmunol.126.6.2466",
      "volume": "126",
      "year": "1981",
      "unstructured": "BOYD, A.W., THE REGULATION OF GROWTH AND DIFFERENTIATION OF A MURINE B-CELL LYMPHOMA .2. THE INHIBITION OF WEHI-231 BY ANTI-IMMUNOGLOBULIN ANTIBODIES, JOURNAL OF IMMUNOLOGY 126: 2466 (1981).",
      "journal-title": "JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_4_1",
      "doi-asserted-by": "crossref",
      "first-page": "441",
      "DOI": "10.1002/j.1460-2075.1990.tb08129.x",
      "volume": "9",
      "year": "1990",
      "unstructured": "CAMPBELL, K.S., B-LYMPHOCYTE ANTIGEN RECEPTORS (MLG) ARE NON-COVALENTLY ASSOCIATED WITH A DISULFIDE LINKED, INDUCIBLY PHOSPHORYLATED GLYCOPROTEIN COMPLEX, EMBO JOURNAL 9: 441 (1990).",
      "journal-title": "EMBO JOURNAL"
    },
    {
      "key": "e_1_2_1_5_1",
      "doi-asserted-by": "crossref",
      "first-page": "2125",
      "DOI": "10.1002/j.1460-2075.1990.tb07381.x",
      "volume": "9",
      "year": "1990",
      "unstructured": "CAMPBELL, M.A., PROTEIN TYROSINE PHOSPHORYLATION IN INDUCED IN MURINE LYMPHOCYTES-B IN RESPONSE TO STIMULATION WITH ANTIIMMUNOGLOBULIN, EMBO JOURNAL 9: 2125 (1990).",
      "journal-title": "EMBO JOURNAL"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "crossref",
      "first-page": "410",
      "DOI": "10.1038/296410a0",
      "volume": "296",
      "year": "1982",
      "unstructured": "CHENG, H.L., STRUCTURE OF GENES FOR MEMBRANE AND SECRETED MURINE IGD HEAVY-CHAINS, NATURE 296: 410 (1982).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_7_1",
      "first-page": "85",
      "year": "1990",
      "unstructured": "Cooper, J. A., Peptides and Protein Phosphorylation: 85 (1990).",
      "journal-title": "Peptides and Protein Phosphorylation"
    },
    {
      "key": "e_1_2_1_8_1",
      "doi-asserted-by": "crossref",
      "first-page": "1523",
      "DOI": "10.1084/jem.155.5.1523",
      "volume": "155",
      "year": "1982",
      "unstructured": "DEFRANCO, A.L., FREQUENCY OF LYMPHOCYTES-B RESPONSIVE TO ANTI-IMMUNOGLOBULIN, JOURNAL OF EXPERIMENTAL MEDICINE 155: 1523 (1982).",
      "journal-title": "JOURNAL OF EXPERIMENTAL MEDICINE"
    },
    {
      "key": "e_1_2_1_9_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.2404338"
    },
    {
      "key": "e_1_2_1_10_1",
      "doi-asserted-by": "crossref",
      "first-page": "3604",
      "DOI": "10.4049/jimmunol.139.11.3604",
      "volume": "139",
      "year": "1987",
      "unstructured": "GOLD, M.R., INVOLVEMENT OF A GUANINE NUCLEOTIDE-BINDING COMPONENT IN MEMBRANE IGM-STIMULATED PHOSPHOINOSITIDE BREAKDOWN, JOURNAL OF IMMUNOLOGY 139: 3604 (1987).",
      "journal-title": "JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_11_1",
      "doi-asserted-by": "crossref",
      "first-page": "810",
      "DOI": "10.1038/345810a0",
      "volume": "345",
      "year": "1990",
      "unstructured": "GOLD, M.R., STIMULATION OF PROTEIN TYROSINE PHOSPHORYLATION BY THE LYMPHOCYTE-B ANTIGEN RECEPTOR, NATURE 345: 810 (1990).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_12_1",
      "doi-asserted-by": "crossref",
      "first-page": "385",
      "DOI": "10.1038/342385a0",
      "volume": "342",
      "year": "1989",
      "unstructured": "GOODNOW, C.C., NATURE 342: 385 (1989).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_13_1",
      "doi-asserted-by": "crossref",
      "first-page": "1444",
      "DOI": "10.4049/jimmunol.142.5.1444",
      "volume": "142",
      "year": "1989",
      "unstructured": "GRUBER, M.F., J IMMUNOL 142: 1444 (1989).",
      "journal-title": "J IMMUNOL"
    },
    {
      "key": "e_1_2_1_14_1",
      "doi-asserted-by": "crossref",
      "first-page": "4087",
      "DOI": "10.4049/jimmunol.134.6.4087",
      "volume": "134",
      "year": "1985",
      "unstructured": "GRUPP, S.A., INCREASED PHOSPHATIDYLINOSITOL METABOLISM IS AN IMPORTANT BUT NOT AN OBLIGATORY EARLY EVENT IN LYMPHOCYTE-B ACTIVATION, JOURNAL OF IMMUNOLOGY 134: 4087 (1985).",
      "journal-title": "JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_15_1",
      "first-page": "3035",
      "volume": "8",
      "year": "1988",
      "unstructured": "HAMAGUCHI, M, PHOSPHORYLATION OF CELLULAR PROTEINS IN ROUS-SARCOMA VIRUS-INFECTED CELLS - ANALYSIS BY USE OF ANTI-PHOSPHOTYROSINE ANTIBODIES, MOLECULAR AND CELLULAR BIOLOGY 8: 3035 (1988).",
      "journal-title": "MOLECULAR AND CELLULAR BIOLOGY"
    },
    {
      "key": "e_1_2_1_16_1",
      "doi-asserted-by": "crossref",
      "first-page": "3135",
      "DOI": "10.4049/jimmunol.140.9.3135",
      "volume": "140",
      "year": "1988",
      "unstructured": "HARNETT, M.M., G-PROTEIN COUPLING OF ANTIGEN RECEPTOR-STIMULATED POLYPHOSPHOINOSITIDE HYDROLYSIS IN B-CELLS, JOURNAL OF IMMUNOLOGY 140: 3135 (1988).",
      "journal-title": "JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_17_1",
      "doi-asserted-by": "crossref",
      "first-page": "760",
      "DOI": "10.1038/343760a0",
      "volume": "343",
      "year": "1990",
      "unstructured": "HOMBACH, J, MOLECULAR-COMPONENTS OF THE B-CELL ANTIGEN RECEPTOR COMPLEX OF THE IGM CLASS, NATURE 343: 760 (1990).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_18_1",
      "doi-asserted-by": "crossref",
      "first-page": "897",
      "DOI": "10.1146/annurev.bi.54.070185.004341",
      "volume": "54",
      "year": "1985",
      "unstructured": "HUNTER, T, PROTEIN-TYROSINE KINASES, ANNUAL REVIEW OF BIOCHEMISTRY 54: 897 (1985).",
      "journal-title": "ANNUAL REVIEW OF BIOCHEMISTRY"
    },
    {
      "key": "e_1_2_1_19_1",
      "doi-asserted-by": "crossref",
      "first-page": "549",
      "DOI": "10.4049/jimmunol.122.2.549",
      "volume": "122",
      "year": "1979",
      "unstructured": "KIM, K.J., ESTABLISHMENT AND CHARACTERIZATION OF BALB-C LYMPHOMA LINES WITH B-CELL PROPERTIES, JOURNAL OF IMMUNOLOGY 122: 549 (1979).",
      "journal-title": "JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_20_1",
      "doi-asserted-by": "crossref",
      "first-page": "19",
      "DOI": "10.1111/j.1600-065X.1987.tb01170.x",
      "volume": "99",
      "year": "1987",
      "unstructured": "KLAUS, GGB, RECEPTOR SIGNALING AND CROSSTALK IN LYMPHOCYTES-B, IMMUNOLOGICAL REVIEWS 99: 19 (1987).",
      "journal-title": "IMMUNOLOGICAL REVIEWS"
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "crossref",
      "first-page": "2162",
      "DOI": "10.4049/jimmunol.137.7.2162",
      "volume": "137",
      "year": "1986",
      "unstructured": "MIZUGUCHI, J, MEMBRANE IGM, IGD, AND IGG ACT AS SIGNAL TRANSMISSION MOLECULES IN A SERIES OF B-LYMPHOMAS, JOURNAL OF IMMUNOLOGY 137: 2162 (1986).",
      "journal-title": "JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_22_1",
      "doi-asserted-by": "crossref",
      "first-page": "273",
      "DOI": "10.1016/0167-4889(89)90146-8",
      "volume": "1013",
      "year": "1989",
      "unstructured": "MONROE, J.G., INVOLVEMENT OF A SPECIFIC GUANINE-NUCLEOTIDE BINDING-PROTEIN IN RECEPTOR IMMUNOGLOBULIN STIMULATED INOSITOL PHOSPHOLIPID HYDROLYSIS, BIOCHIMICA ET BIOPHYSICA ACTA 1013: 273 (1989).",
      "journal-title": "BIOCHIMICA ET BIOPHYSICA ACTA"
    },
    {
      "key": "e_1_2_1_23_1",
      "first-page": "33",
      "volume": "1",
      "year": "1989",
      "unstructured": "NOSSAL, G. J. V., ANNUAL REVIEW OF IMMUNOLOGY 1: 33 (1989).",
      "journal-title": "ANNUAL REVIEW OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_24_1",
      "doi-asserted-by": "crossref",
      "first-page": "272",
      "DOI": "10.1038/320272a0",
      "volume": "320",
      "year": "1986",
      "unstructured": "OETTGEN, H.C., A T3-LIKE PROTEIN COMPLEX ASSOCIATED WITH THE ANTIGEN RECEPTOR ON MURINE T-CELLS, NATURE 320: 272 (1986).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_25_1",
      "doi-asserted-by": "crossref",
      "first-page": "303",
      "DOI": "10.1016/0092-8674(80)90616-9",
      "volume": "20",
      "year": "1980",
      "unstructured": "ROGERS, J, 2 MESSENGER-RNAS WITH DIFFERENT 3' ENDS ENCODE MEMBRANE-BOUND AND SECRETED FORMS OF IMMUNOGLOBULIN-MU CHAIN, CELL 20: 303 (1980).",
      "journal-title": "CELL"
    },
    {
      "key": "e_1_2_1_26_1",
      "first-page": "5190",
      "volume": "85",
      "year": "1988",
      "unstructured": "RUDD, C.E., THE CD4 RECEPTOR IS COMPLEXED IN DETERGENT LYSATES TO A PROTEIN-TYROSINE KINASE (PP58) FROM HUMAN LYMPHOCYTES-T, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 5190 (1988).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_27_1",
      "doi-asserted-by": "crossref",
      "first-page": "3457",
      "DOI": "10.1002/j.1460-2075.1988.tb03220.x",
      "volume": "7",
      "year": "1988",
      "unstructured": "SAKAGUCHI, N, LYMPHOCYTE-B LINEAGE-RESTRICTED EXPRESSION OF MB-1, A GENE WITH CD3-LIKE STRUCTURAL-PROPERTIES, EMBO JOURNAL 7: 3457 (1988).",
      "journal-title": "EMBO JOURNAL"
    },
    {
      "key": "e_1_2_1_28_1",
      "first-page": "73",
      "year": "1990",
      "unstructured": "Semba, K., Genes and Cancer: 73 (1990).",
      "journal-title": "Genes and Cancer"
    },
    {
      "key": "e_1_2_1_29_1",
      "doi-asserted-by": "crossref",
      "first-page": "8695",
      "DOI": "10.1021/bi00424a001",
      "volume": "27",
      "year": "1988",
      "unstructured": "TONKS, N.K., BIOCHEMISTRY-US 27: 8695 (1988).",
      "journal-title": "BIOCHEMISTRY-US"
    },
    {
      "key": "e_1_2_1_30_1",
      "first-page": "2008",
      "volume": "79",
      "year": "1982",
      "unstructured": "TYLER, B.M., MESSENGER-RNA FOR SURFACE-IMMUNOGLOBULIN GAMMA-CHAINS ENCODES A HIGHLY CONSERVED TRANSMEMBRANE SEQUENCE AND A 28-RESIDUE INTRACELLULAR DOMAIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 2008 (1982).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"
    },
    {
      "key": "e_1_2_1_31_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(90)90801-K"
    },
    {
      "key": "e_1_2_1_32_1",
      "doi-asserted-by": "crossref",
      "first-page": "804",
      "DOI": "10.1002/eji.1830121003",
      "volume": "12",
      "year": "1982",
      "unstructured": "VASILOV, R.G., BIOSYNTHESIS OF MURINE IMMUNOGLOBULIN-D - HETEROGENEITY OF GLYCOSYLATION, EUROPEAN JOURNAL OF IMMUNOLOGY 12: 804 (1982).",
      "journal-title": "EUROPEAN JOURNAL OF IMMUNOLOGY"
    },
    {
      "key": "e_1_2_1_33_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(88)90053-0"
    },
    {
      "key": "e_1_2_1_34_1",
      "doi-asserted-by": "crossref",
      "first-page": "257",
      "DOI": "10.1038/338257a0",
      "volume": "338",
      "year": "1989",
      "unstructured": "VEILLETTE, A, SIGNAL TRANSDUCTION THROUGH THE CD4 RECEPTOR INVOLVES THE ACTIVATION OF THE INTERNAL MEMBRANE TYROSINE-PROTEIN KINASE P56LCK, NATURE 338: 257 (1989).",
      "journal-title": "NATURE"
    },
    {
      "key": "e_1_2_1_35_1",
      "doi-asserted-by": "crossref",
      "first-page": "449",
      "DOI": "10.1002/j.1460-2075.1990.tb08130.x",
      "volume": "9",
      "year": "1990",
      "unstructured": "WIENANDS, J, MOLECULAR-COMPONENTS OF THE B-CELL ANTIGEN RECEPTOR COMPLEX OF CLASS IGD DIFFER PARTLY FROM THOSE OF IGM, EMBO JOURNAL 9: 449 (1990).",
      "journal-title": "EMBO JOURNAL"
    },
    {
      "key": "e_1_2_1_36_1",
      "first-page": "237",
      "volume": "7",
      "year": "1987",
      "unstructured": "YAMANASHI, Y, THE YES-RELATED CELLULAR GENE LYN ENCODES A POSSIBLE TYROSINE KINASE SIMILAR TO P56LCK, MOLECULAR AND CELLULAR BIOLOGY 7: 237 (1987).",
      "journal-title": "MOLECULAR AND CELLULAR BIOLOGY"
    },
    {
      "key": "e_1_2_1_37_1",
      "first-page": "6538",
      "volume": "86",
      "year": "1989",
      "unstructured": "YAMANASHI, Y, SELECTIVE EXPRESSION OF A PROTEIN-TYROSINE KINASE, P56LYN, IN HEMATOPOIETIC-CELLS AND ASSOCIATION WITH PRODUCTION OF HUMAN T-CELL LYMPHOTROPHIC VIRUS TYPE-I, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 6538 (1989).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_38_1",
      "unstructured": "YAMANASHI Y unpublished data."
    },
    {
      "key": "e_1_2_1_39_1",
      "first-page": "2623",
      "volume": "79",
      "year": "1982",
      "unstructured": "YAMAWAKIKATAOKA, Y, NUCLEOTIDE-SEQUENCES OF GENE SEGMENTS ENCODING MEMBRANE DOMAINS OF IMMUNOGLOBULIN GAMMA-CHAINS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79: 2623 (1982).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"
    }
  ],
  "container-title": "Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.science.org/doi/pdf/10.1126/science.1702903",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        11
      ]
    ],
    "date-time": "2024-01-11T15:14:40Z",
    "timestamp": 1704986080000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.science.org/doi/10.1126/science.1702903"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1991,
        1,
        11
      ]
    ]
  },
  "references-count": 39,
  "journal-issue": {
    "issue": "4990",
    "published-print": {
      "date-parts": [
        [
          1991,
          1,
          11
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.1702903"
  ],
  "URL": "http://dx.doi.org/10.1126/science.1702903",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1991,
        1,
        11
      ]
    ]
  }
}