DOI: 10.1126/science.1699274. Recovery of Mitogenic Activity of a Growth Factor Mutant with a Nuclear Translocation Sequence

Recovery of Mitogenic Activity of a Growth Factor Mutant with a Nuclear Translocation Sequence

10.1126/science.1699274

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Heparin-binding growth factor-1 (HBGF-1) is an angiogenic polypeptide mitogen for mesoderm- and neuroectoderm-derived cells in vitro and remains biologically active after truncation of the amino-terminal domain (HBGF-1α) of the HBGF-1β precursor. Polymerase chain reaction mutagenesis and prokaryotic expression systems were used to prepare a mutant of HBGF-1α lacking a putative nuclear translocation sequence (amino acid residues 21 to 27; HBGF-1U). Although HBGF-1U retains its ability to bind to heparin, HBGF-1U fails to induce DNA synthesis and cell proliferation at concentrations sufficient to induce intracellular receptor-mediated tyrosine phosphorylation and c- fos expression. Attachment of the nuclear translocation sequence from yeast histone 2B at the amino terminus of HBGF-1U yields a chimeric polypeptide (HBGF-1U2) with mitogenic activity in vitro and indicates that nuclear translocation is important for this biological response.

Bibliography

Imamura, T., Engleka, K., Zhan, X., Tokita, Y., Forough, R., Roeder, D., Jackson, A., Maier, J. A. M., Hla, T., & Maciag, T. (1990). Recovery of Mitogenic Activity of a Growth Factor Mutant with a Nuclear Translocation Sequence. Science, 249(4976), 1567â1570.

Authors 10

Toru Imamura (first)
Kurt Engleka (additional)
Xi Zhan (additional)
Yoshihito Tokita (additional)
Reza Forough (additional)
David Roeder (additional)
Anthony Jackson (additional)
Jeanette A. M. Maier (additional)
Timothy Hla (additional)
Thomas Maciag (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 10:44 a.m.)
Indexed	3 weeks, 6 days ago (Aug. 7, 2025, 4:55 a.m.)
Issued	34 years, 11 months ago (Sept. 28, 1990)
Published	34 years, 11 months ago (Sept. 28, 1990)
Published Print	34 years, 11 months ago (Sept. 28, 1990)

Funders 0

None

BibTeX

@article{Imamura_1990, title={Recovery of Mitogenic Activity of a Growth Factor Mutant with a Nuclear Translocation Sequence}, volume={249}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1699274}, DOI={10.1126/science.1699274}, number={4976}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Imamura, Toru and Engleka, Kurt and Zhan, Xi and Tokita, Yoshihito and Forough, Reza and Roeder, David and Jackson, Anthony and Maier, Jeanette A. M. and Hla, Timothy and Maciag, Thomas}, year={1990}, month=sep, pages={1567–1570} }

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