DOI: 10.1126/science.1697697. Heart Rate Regulation by G Proteins Acting on the Cardiac Pacemaker Channel

Heart Rate Regulation by G Proteins Acting on the Cardiac Pacemaker Channel

10.1126/science.1697697

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Heart rate is determined by pacemaker currents, of which the most important is the hyperpolarization-activated current I f . Heart rate and I f are increased by β-adrenergic agonists and decreased by muscarinic agonists released from cardiac sympathetic and vagal nerves, respectively. The hypothesis that the receptors for each agonist are directly coupled to I f channels by G proteins was tested. Under substrate-free conditions, preactivated G protein G s stimulated and preactivated G protein G o inhibited I f channels of sinoatrial node pacemaker cells. These effects were mimicked by the corresponding preactivated α subunits of the G proteins. Unexpectedly, the two G proteins acted simultaneously, with G o being the more potent. This result may explain in molecular terms the classical observation in cardiac physiology, that vagal inhibition of heart rate is much greater on a background of sympathetic stimulation.

Bibliography

Yatani, A., Okabe, K., Codina, J., Birnbaumer, L., & Brown, A. M. (1990). Heart Rate Regulation by G Proteins Acting on the Cardiac Pacemaker Channel. Science, 249(4973), 1163â1166.

Authors 5

A. Yatani (first)
K. Okabe (additional)
J. Codina (additional)
L. Birnbaumer (additional)
A. M. Brown (additional)

References 33 Referenced 65

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Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 10:51 a.m.)
Indexed	2 days ago (Sept. 4, 2025, 10:16 a.m.)
Issued	34 years, 11 months ago (Sept. 7, 1990)
Published	34 years, 11 months ago (Sept. 7, 1990)
Published Print	34 years, 11 months ago (Sept. 7, 1990)

Funders 0

None

BibTeX

@article{Yatani_1990, title={Heart Rate Regulation by G Proteins Acting on the Cardiac Pacemaker Channel}, volume={249}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1697697}, DOI={10.1126/science.1697697}, number={4973}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Yatani, A. and Okabe, K. and Codina, J. and Birnbaumer, L. and Brown, A. M.}, year={1990}, month=sep, pages={1163–1166} }

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