DOI: 10.1126/science.1694307. Binding of Transforming Protein, P47 <sup> <i>gag-crk</i> </sup> , to a Broad Range of Phosphotyrosine-containing Proteins

Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

10.1126/science.1694307

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Although the oncogene product of CT10 virus, P47 gag-crk , does not itself phosphorylate proteins at tyrosine residues, it elevates phosphotyrosine in transformed cells. The P47 gag-crk oncoprotein contains SH2 and SH3 domains, which are conserved in several proteins involved in signal transduction, including nonreceptor tyrosine kinases. P47 gag-crk bound in vitro to phosphotyrosine-containing proteins from crk -transformed cells and from cells transformed by oncogenic tyrosine kinases. The association between P47 gag-crk and p60 v- src , a phosphotyrosine-containing protein, was abolished by dephosphorylation of p60 v- src . This suggests that the SH2 and SH3 regions function to regulate protein interactions in a phosphotyrosine-dependent manner.

Bibliography

Matsuda, M., Mayer, B. J., Fukui, Y., & Hanafusa, H. (1990). Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins. Science, 248(4962), 1537â1539.

Authors 4

Michiyuki Matsuda (first)
Bruce J. Mayer (additional)
Yasuhisa Fukui (additional)
Hidesaburo Hanafusa (additional)

References 34 Referenced 314

10.1126/science.2420005
EMORI, Y, A 2ND TYPE OF RAT PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE-C CONTAINING A SRC-RELATED SEQUENCE NOT ESSENTIAL FOR PHOSPHOINOSITIDE-HYDROLYZING ACTIVITY, JOURNAL OF BIOLOGICAL CHEMISTRY 264: 21885 (1989). (10.1016/S0021-9258(20)88267-2) / JOURNAL OF BIOLOGICAL CHEMISTRY (1989)
GRAF, T, AVIAN LEUKEMIA VIRUSES - INTERACTION WITH THEIR TARGET-CELLS INVIVO AND INVITRO, BIOCHIMICA ET BIOPHYSICA ACTA 516: 269 (1978). / BIOCHIMICA ET BIOPHYSICA ACTA (1978)
HAMAGUCHI, M, PHOSPHORYLATION OF CELLULAR PROTEINS IN ROUS-SARCOMA VIRUS-INFECTED CELLS - ANALYSIS BY USE OF ANTI-PHOSPHOTYROSINE ANTIBODIES, MOLECULAR AND CELLULAR BIOLOGY 8: 3035 (1988). / MOLECULAR AND CELLULAR BIOLOGY (1988)
Hunter, T., Proceedings of the National Academy of Sciences of the United States of America 77: 1311 (1980). / Proceedings of the National Academy of Sciences of the United States of America (1980)
JOVE, R, CELL-TRANSFORMATION BY THE VIRAL SRC ONCOGENE, ANNUAL REVIEW OF CELL BIOLOGY 3: 31 (1987). (10.1146/annurev.cb.03.110187.000335) / ANNUAL REVIEW OF CELL BIOLOGY (1987)
KAWAI, S, TRANSFORMATION OF RAT-CELLS BY FUSION-INFECTION WITH ROUS-SARCOMA VIRUS, JOURNAL OF VIROLOGY 34: 772 (1980). (10.1128/jvi.34.3.772-776.1980) / JOURNAL OF VIROLOGY (1980)
KAWAI, S, CHARACTERIZATION OF Y73, AN AVIAN-SARCOMA VIRUS - A UNIQUE TRANSFORMING GENE AND ITS PRODUCT, A PHOSPHOPOLYPROTEIN WITH PROTEIN-KINASE ACTIVITY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 77: 6199 (1980). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES (1980)
KIMURA, G, RAT CELL LINE 3Y1 AND ITS VIROGENIC POLYOMA-TRANSFORMED AND SV40-TRANSFORMED DERIVATIVES, INTERNATIONAL JOURNAL OF CANCER 15: 694 (1975). (10.1002/ijc.2910150419) / INTERNATIONAL JOURNAL OF CANCER (1975)
KOCH, C.A., THE COMMON SRC HOMOLOGY REGION-2 DOMAIN OF CYTOPLASMIC SIGNALING PROTEINS IS A POSITIVE EFFECTOR OF V-FPS TYROSINE KINASE FUNCTION, MOLECULAR AND CELLULAR BIOLOGY 9: 4131 (1989). / MOLECULAR AND CELLULAR BIOLOGY (1989)
KUMJIAN, D.A., PLATELET-DERIVED GROWTH-FACTOR (PDGF) BINDING PROMOTES PHYSICAL ASSOCIATION OF PDGF RECEPTOR WITH PHOSPHOLIPASE-C, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 8232 (1989). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1989)
LIPSICH, L.A., ISOLATION OF MONOCLONAL-ANTIBODIES THAT RECOGNIZE THE TRANSFORMING PROTEINS OF AVIAN-SARCOMA VIRUSES, JOURNAL OF VIROLOGY 48: 352 (1983). (10.1128/jvi.48.2.352-360.1983) / JOURNAL OF VIROLOGY (1983)
10.1016/0092-8674(89)90047-0
MARGOLIS, B, TYROSINE KINASE-ACTIVITY IS ESSENTIAL FOR THE ASSOCIATION OF PHOSPHOLIPASE-C-GAMMA WITH THE EPIDERMAL GROWTH-FACTOR RECEPTOR, MOLECULAR AND CELLULAR BIOLOGY 10: 435 (1990). / MOLECULAR AND CELLULAR BIOLOGY (1990)
MARSHALL C.P. unpublished data.
Matuoka, M., Journal of Biological Chemistry 265: 12000 (1990). (10.1016/S0021-9258(19)38499-6) / Journal of Biological Chemistry (1990)
MAYER, B. J., COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 53: 907 (1988). (10.1101/SQB.1988.053.01.104) / COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY (1988)
Mayer, B. J., Journal of Virology 64: 3581 (1990). (10.1128/jvi.64.8.3581-3589.1990) / Journal of Virology (1990)
10.1038/332272a0
10.1073/pnas.87.7.2638
MCCARLEY, D.J., INHIBITION OF THE TYROSINE KINASE-ACTIVITY OF V-SRC, V-FGR, AND V-YES GENE-PRODUCTS BY A MONOCLONAL-ANTIBODY WHICH BINDS BOTH AMINO AND CARBOXY PEPTIDE-FRAGMENTS OF PP60V-SRC, JOURNAL OF VIROLOGY 61: 1927 (1987). (10.1128/jvi.61.6.1927-1937.1987) / JOURNAL OF VIROLOGY (1987)
10.1016/0092-8674(89)90048-2
PAWSON, T, NON-CATALYTIC DOMAINS OF CYTOPLASMIC PROTEIN-TYROSINE KINASES - REGULATORY ELEMENTS IN SIGNAL TRANSDUCTION, ONCOGENE 3: 491 (1988). / ONCOGENE (1988)
POTTS, W.M., EPITOPE MAPPING OF MONOCLONAL-ANTIBODIES TO GAG PROTEIN-P19 OF AVIAN-SARCOMA AND LEUKEMIA VIRUSES, JOURNAL OF GENERAL VIROLOGY 68: 3177 (1987). (10.1099/0022-1317-68-12-3177) / JOURNAL OF GENERAL VIROLOGY (1987)
REICHMAN C.T. unpublished data.
SADOWSKI, I, A NONCATALYTIC DOMAIN CONSERVED AMONG CYTOPLASMIC PROTEIN-TYROSINE KINASES MODIFIES THE KINASE FUNCTION AND TRANSFORMING ACTIVITY OF FUJINAMI SARCOMA-VIRUS P130GAG-FPS, MOLECULAR AND CELLULAR BIOLOGY 6: 4396 (1986). / MOLECULAR AND CELLULAR BIOLOGY (1986)
SEFTON, B.M., PHOSPHORYLATION AND METABOLISM OF THE TRANSFORMING PROTEIN OF ROUS-SARCOMA VIRUS, JOURNAL OF VIROLOGY 41: 813 (1982). (10.1128/jvi.41.3.813-820.1982) / JOURNAL OF VIROLOGY (1982)
10.1038/332269a0
SUH, P.G., INOSITOL PHOSPHOLIPID-SPECIFIC PHOSPHOLIPASE-C - COMPLETE CDNA AND PROTEIN SEQUENCES AND SEQUENCE HOMOLOGY TO TYROSINE KINASE-RELATED ONCOGENE PRODUCTS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 5419 (1988). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1988)
TAKEYA, T, STRUCTURE AND SEQUENCE OF THE CELLULAR GENE HOMOLOGOUS TO THE RSV SRC GENE AND THE MECHANISM FOR GENERATING THE TRANSFORMING VIRUS, CELL 32: 881 (1983). (10.1016/0092-8674(83)90073-9) / CELL (1983)
10.1126/science.3201259
10.1038/335090a0
WAHL, M.I., PLATELET-DERIVED GROWTH-FACTOR INDUCES RAPID AND SUSTAINED TYROSINE PHOSPHORYLATION OF PHOSPHOLIPASE C-GAMMA IN QUIESCENT BALB/C-3T3-CELLS, MOLECULAR AND CELLULAR BIOLOGY 9: 2934 (1989). / MOLECULAR AND CELLULAR BIOLOGY (1989)
WAHL, M.I., EPIDERMAL GROWTH-FACTOR STIMULATES TYROSINE PHOSPHORYLATION OF PHOSPHOLIPASE C-II INDEPENDENTLY OF RECEPTOR INTERNALIZATION AND EXTRACELLULAR CALCIUM, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 1568 (1989). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1989)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 9:01 a.m.)
Indexed	11 months, 1 week ago (Sept. 15, 2024, 6:11 p.m.)
Issued	35 years, 2 months ago (June 22, 1990)
Published	35 years, 2 months ago (June 22, 1990)
Published Print	35 years, 2 months ago (June 22, 1990)

Funders 0

None

BibTeX

@article{Matsuda_1990, title={Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins}, volume={248}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1694307}, DOI={10.1126/science.1694307}, number={4962}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Matsuda, Michiyuki and Mayer, Bruce J. and Fukui, Yasuhisa and Hanafusa, Hidesaburo}, year={1990}, month=jun, pages={1537–1539} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        9,
        15
      ]
    ],
    "date-time": "2024-09-15T22:11:03Z",
    "timestamp": 1726438263621
  },
  "reference-count": 34,
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "issue": "4962",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1990,
        6,
        22
      ]
    ]
  },
  "abstract": "<jats:p>\n            Although the oncogene product of CT10 virus, P47\n            <jats:sup>\n              <jats:italic>gag-crk</jats:italic>\n            </jats:sup>\n            , does not itself phosphorylate proteins at tyrosine residues, it elevates phosphotyrosine in transformed cells. The P47\n            <jats:sup>\n              <jats:italic>gag-crk</jats:italic>\n            </jats:sup>\n            oncoprotein contains SH2 and SH3 domains, which are conserved in several proteins involved in signal transduction, including nonreceptor tyrosine kinases. P47\n            <jats:sup>\n              <jats:italic>gag-crk</jats:italic>\n            </jats:sup>\n            bound in vitro to phosphotyrosine-containing proteins from\n            <jats:italic>crk</jats:italic>\n            -transformed cells and from cells transformed by oncogenic tyrosine kinases. The association between P47\n            <jats:sup>\n              <jats:italic>gag-crk</jats:italic>\n            </jats:sup>\n            and p60\n            <jats:sup>\n              v-\n              <jats:italic>src</jats:italic>\n            </jats:sup>\n            , a phosphotyrosine-containing protein, was abolished by dephosphorylation of p60\n            <jats:sup>\n              v-\n              <jats:italic>src</jats:italic>\n            </jats:sup>\n            . This suggests that the SH2 and SH3 regions function to regulate protein interactions in a phosphotyrosine-dependent manner.\n          </jats:p>",
  "DOI": "10.1126/science.1694307",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        10,
        5
      ]
    ],
    "date-time": "2006-10-05T22:10:14Z",
    "timestamp": 1160086214000
  },
  "page": "1537-1539",
  "source": "Crossref",
  "is-referenced-by-count": 314,
  "title": "Binding of Transforming Protein, P47\n            <sup>\n              <i>gag-crk</i>\n            </sup>\n            , to a Broad Range of Phosphotyrosine-containing Proteins",
  "prefix": "10.1126",
  "volume": "248",
  "author": [
    {
      "given": "Michiyuki",
      "family": "Matsuda",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Rockefeller University, New York, NY 10021."
        }
      ]
    },
    {
      "given": "Bruce J.",
      "family": "Mayer",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Rockefeller University, New York, NY 10021."
        }
      ]
    },
    {
      "given": "Yasuhisa",
      "family": "Fukui",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Rockefeller University, New York, NY 10021."
        }
      ]
    },
    {
      "given": "Hidesaburo",
      "family": "Hanafusa",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Rockefeller University, New York, NY 10021."
        }
      ]
    }
  ],
  "member": "221",
  "reference": [
    {
      "key": "e_1_2_1_1_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.2420005"
    },
    {
      "key": "e_1_2_1_2_1",
      "doi-asserted-by": "crossref",
      "first-page": "21885",
      "DOI": "10.1016/S0021-9258(20)88267-2",
      "volume": "264",
      "year": "1989",
      "unstructured": "EMORI, Y, A 2ND TYPE OF RAT PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE-C CONTAINING A SRC-RELATED SEQUENCE NOT ESSENTIAL FOR PHOSPHOINOSITIDE-HYDROLYZING ACTIVITY, JOURNAL OF BIOLOGICAL CHEMISTRY 264: 21885 (1989).",
      "journal-title": "JOURNAL OF BIOLOGICAL CHEMISTRY"
    },
    {
      "key": "e_1_2_1_3_1",
      "first-page": "269",
      "volume": "516",
      "year": "1978",
      "unstructured": "GRAF, T, AVIAN LEUKEMIA VIRUSES - INTERACTION WITH THEIR TARGET-CELLS INVIVO AND INVITRO, BIOCHIMICA ET BIOPHYSICA ACTA 516: 269 (1978).",
      "journal-title": "BIOCHIMICA ET BIOPHYSICA ACTA"
    },
    {
      "key": "e_1_2_1_4_1",
      "first-page": "3035",
      "volume": "8",
      "year": "1988",
      "unstructured": "HAMAGUCHI, M, PHOSPHORYLATION OF CELLULAR PROTEINS IN ROUS-SARCOMA VIRUS-INFECTED CELLS - ANALYSIS BY USE OF ANTI-PHOSPHOTYROSINE ANTIBODIES, MOLECULAR AND CELLULAR BIOLOGY 8: 3035 (1988).",
      "journal-title": "MOLECULAR AND CELLULAR BIOLOGY"
    },
    {
      "key": "e_1_2_1_5_1",
      "first-page": "1311",
      "volume": "77",
      "year": "1980",
      "unstructured": "Hunter, T., Proceedings of the National Academy of Sciences of the United States of America 77: 1311 (1980).",
      "journal-title": "Proceedings of the National Academy of Sciences of the United States of America"
    },
    {
      "key": "e_1_2_1_6_1",
      "doi-asserted-by": "crossref",
      "first-page": "31",
      "DOI": "10.1146/annurev.cb.03.110187.000335",
      "volume": "3",
      "year": "1987",
      "unstructured": "JOVE, R, CELL-TRANSFORMATION BY THE VIRAL SRC ONCOGENE, ANNUAL REVIEW OF CELL BIOLOGY 3: 31 (1987).",
      "journal-title": "ANNUAL REVIEW OF CELL BIOLOGY"
    },
    {
      "key": "e_1_2_1_7_1",
      "doi-asserted-by": "crossref",
      "first-page": "772",
      "DOI": "10.1128/jvi.34.3.772-776.1980",
      "volume": "34",
      "year": "1980",
      "unstructured": "KAWAI, S, TRANSFORMATION OF RAT-CELLS BY FUSION-INFECTION WITH ROUS-SARCOMA VIRUS, JOURNAL OF VIROLOGY 34: 772 (1980).",
      "journal-title": "JOURNAL OF VIROLOGY"
    },
    {
      "key": "e_1_2_1_8_1",
      "first-page": "6199",
      "volume": "77",
      "year": "1980",
      "unstructured": "KAWAI, S, CHARACTERIZATION OF Y73, AN AVIAN-SARCOMA VIRUS - A UNIQUE TRANSFORMING GENE AND ITS PRODUCT, A PHOSPHOPOLYPROTEIN WITH PROTEIN-KINASE ACTIVITY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 77: 6199 (1980).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES"
    },
    {
      "key": "e_1_2_1_9_1",
      "doi-asserted-by": "crossref",
      "first-page": "694",
      "DOI": "10.1002/ijc.2910150419",
      "volume": "15",
      "year": "1975",
      "unstructured": "KIMURA, G, RAT CELL LINE 3Y1 AND ITS VIROGENIC POLYOMA-TRANSFORMED AND SV40-TRANSFORMED DERIVATIVES, INTERNATIONAL JOURNAL OF CANCER 15: 694 (1975).",
      "journal-title": "INTERNATIONAL JOURNAL OF CANCER"
    },
    {
      "key": "e_1_2_1_10_1",
      "first-page": "4131",
      "volume": "9",
      "year": "1989",
      "unstructured": "KOCH, C.A., THE COMMON SRC HOMOLOGY REGION-2 DOMAIN OF CYTOPLASMIC SIGNALING PROTEINS IS A POSITIVE EFFECTOR OF V-FPS TYROSINE KINASE FUNCTION, MOLECULAR AND CELLULAR BIOLOGY 9: 4131 (1989).",
      "journal-title": "MOLECULAR AND CELLULAR BIOLOGY"
    },
    {
      "key": "e_1_2_1_11_1",
      "first-page": "8232",
      "volume": "86",
      "year": "1989",
      "unstructured": "KUMJIAN, D.A., PLATELET-DERIVED GROWTH-FACTOR (PDGF) BINDING PROMOTES PHYSICAL ASSOCIATION OF PDGF RECEPTOR WITH PHOSPHOLIPASE-C, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 8232 (1989).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_12_1",
      "doi-asserted-by": "crossref",
      "first-page": "352",
      "DOI": "10.1128/jvi.48.2.352-360.1983",
      "volume": "48",
      "year": "1983",
      "unstructured": "LIPSICH, L.A., ISOLATION OF MONOCLONAL-ANTIBODIES THAT RECOGNIZE THE TRANSFORMING PROTEINS OF AVIAN-SARCOMA VIRUSES, JOURNAL OF VIROLOGY 48: 352 (1983).",
      "journal-title": "JOURNAL OF VIROLOGY"
    },
    {
      "key": "e_1_2_1_13_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(89)90047-0"
    },
    {
      "key": "e_1_2_1_14_1",
      "first-page": "435",
      "volume": "10",
      "year": "1990",
      "unstructured": "MARGOLIS, B, TYROSINE KINASE-ACTIVITY IS ESSENTIAL FOR THE ASSOCIATION OF PHOSPHOLIPASE-C-GAMMA WITH THE EPIDERMAL GROWTH-FACTOR RECEPTOR, MOLECULAR AND CELLULAR BIOLOGY 10: 435 (1990).",
      "journal-title": "MOLECULAR AND CELLULAR BIOLOGY"
    },
    {
      "key": "e_1_2_1_15_1",
      "unstructured": "MARSHALL C.P. unpublished data."
    },
    {
      "key": "e_1_2_1_16_1",
      "doi-asserted-by": "crossref",
      "first-page": "12000",
      "DOI": "10.1016/S0021-9258(19)38499-6",
      "volume": "265",
      "year": "1990",
      "unstructured": "Matuoka, M., Journal of Biological Chemistry 265: 12000 (1990).",
      "journal-title": "Journal of Biological Chemistry"
    },
    {
      "key": "e_1_2_1_17_1",
      "doi-asserted-by": "crossref",
      "first-page": "907",
      "DOI": "10.1101/SQB.1988.053.01.104",
      "volume": "53",
      "year": "1988",
      "unstructured": "MAYER, B. J., COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 53: 907 (1988).",
      "journal-title": "COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY"
    },
    {
      "key": "e_1_2_1_18_1",
      "doi-asserted-by": "crossref",
      "first-page": "3581",
      "DOI": "10.1128/jvi.64.8.3581-3589.1990",
      "volume": "64",
      "year": "1990",
      "unstructured": "Mayer, B. J., Journal of Virology 64: 3581 (1990).",
      "journal-title": "Journal of Virology"
    },
    {
      "key": "e_1_2_1_19_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/332272a0"
    },
    {
      "key": "e_1_2_1_20_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.87.7.2638"
    },
    {
      "key": "e_1_2_1_21_1",
      "doi-asserted-by": "crossref",
      "first-page": "1927",
      "DOI": "10.1128/jvi.61.6.1927-1937.1987",
      "volume": "61",
      "year": "1987",
      "unstructured": "MCCARLEY, D.J., INHIBITION OF THE TYROSINE KINASE-ACTIVITY OF V-SRC, V-FGR, AND V-YES GENE-PRODUCTS BY A MONOCLONAL-ANTIBODY WHICH BINDS BOTH AMINO AND CARBOXY PEPTIDE-FRAGMENTS OF PP60V-SRC, JOURNAL OF VIROLOGY 61: 1927 (1987).",
      "journal-title": "JOURNAL OF VIROLOGY"
    },
    {
      "key": "e_1_2_1_22_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(89)90048-2"
    },
    {
      "key": "e_1_2_1_23_1",
      "first-page": "491",
      "volume": "3",
      "year": "1988",
      "unstructured": "PAWSON, T, NON-CATALYTIC DOMAINS OF CYTOPLASMIC PROTEIN-TYROSINE KINASES - REGULATORY ELEMENTS IN SIGNAL TRANSDUCTION, ONCOGENE 3: 491 (1988).",
      "journal-title": "ONCOGENE"
    },
    {
      "key": "e_1_2_1_24_1",
      "doi-asserted-by": "crossref",
      "first-page": "3177",
      "DOI": "10.1099/0022-1317-68-12-3177",
      "volume": "68",
      "year": "1987",
      "unstructured": "POTTS, W.M., EPITOPE MAPPING OF MONOCLONAL-ANTIBODIES TO GAG PROTEIN-P19 OF AVIAN-SARCOMA AND LEUKEMIA VIRUSES, JOURNAL OF GENERAL VIROLOGY 68: 3177 (1987).",
      "journal-title": "JOURNAL OF GENERAL VIROLOGY"
    },
    {
      "key": "e_1_2_1_25_1",
      "unstructured": "REICHMAN C.T. unpublished data."
    },
    {
      "key": "e_1_2_1_26_1",
      "first-page": "4396",
      "volume": "6",
      "year": "1986",
      "unstructured": "SADOWSKI, I, A NONCATALYTIC DOMAIN CONSERVED AMONG CYTOPLASMIC PROTEIN-TYROSINE KINASES MODIFIES THE KINASE FUNCTION AND TRANSFORMING ACTIVITY OF FUJINAMI SARCOMA-VIRUS P130GAG-FPS, MOLECULAR AND CELLULAR BIOLOGY 6: 4396 (1986).",
      "journal-title": "MOLECULAR AND CELLULAR BIOLOGY"
    },
    {
      "key": "e_1_2_1_27_1",
      "doi-asserted-by": "crossref",
      "first-page": "813",
      "DOI": "10.1128/jvi.41.3.813-820.1982",
      "volume": "41",
      "year": "1982",
      "unstructured": "SEFTON, B.M., PHOSPHORYLATION AND METABOLISM OF THE TRANSFORMING PROTEIN OF ROUS-SARCOMA VIRUS, JOURNAL OF VIROLOGY 41: 813 (1982).",
      "journal-title": "JOURNAL OF VIROLOGY"
    },
    {
      "key": "e_1_2_1_28_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/332269a0"
    },
    {
      "key": "e_1_2_1_29_1",
      "first-page": "5419",
      "volume": "85",
      "year": "1988",
      "unstructured": "SUH, P.G., INOSITOL PHOSPHOLIPID-SPECIFIC PHOSPHOLIPASE-C - COMPLETE CDNA AND PROTEIN SEQUENCES AND SEQUENCE HOMOLOGY TO TYROSINE KINASE-RELATED ONCOGENE PRODUCTS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 5419 (1988).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    },
    {
      "key": "e_1_2_1_30_1",
      "doi-asserted-by": "crossref",
      "first-page": "881",
      "DOI": "10.1016/0092-8674(83)90073-9",
      "volume": "32",
      "year": "1983",
      "unstructured": "TAKEYA, T, STRUCTURE AND SEQUENCE OF THE CELLULAR GENE HOMOLOGOUS TO THE RSV SRC GENE AND THE MECHANISM FOR GENERATING THE TRANSFORMING VIRUS, CELL 32: 881 (1983).",
      "journal-title": "CELL"
    },
    {
      "key": "e_1_2_1_31_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.3201259"
    },
    {
      "key": "e_1_2_1_32_1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/335090a0"
    },
    {
      "key": "e_1_2_1_33_1",
      "first-page": "2934",
      "volume": "9",
      "year": "1989",
      "unstructured": "WAHL, M.I., PLATELET-DERIVED GROWTH-FACTOR INDUCES RAPID AND SUSTAINED TYROSINE PHOSPHORYLATION OF PHOSPHOLIPASE C-GAMMA IN QUIESCENT BALB/C-3T3-CELLS, MOLECULAR AND CELLULAR BIOLOGY 9: 2934 (1989).",
      "journal-title": "MOLECULAR AND CELLULAR BIOLOGY"
    },
    {
      "key": "e_1_2_1_34_1",
      "first-page": "1568",
      "volume": "86",
      "year": "1989",
      "unstructured": "WAHL, M.I., EPIDERMAL GROWTH-FACTOR STIMULATES TYROSINE PHOSPHORYLATION OF PHOSPHOLIPASE C-II INDEPENDENTLY OF RECEPTOR INTERNALIZATION AND EXTRACELLULAR CALCIUM, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 1568 (1989).",
      "journal-title": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"
    }
  ],
  "container-title": "Science",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.science.org/doi/pdf/10.1126/science.1694307",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        11
      ]
    ],
    "date-time": "2024-01-11T14:01:45Z",
    "timestamp": 1704981705000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.science.org/doi/10.1126/science.1694307"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1990,
        6,
        22
      ]
    ]
  },
  "references-count": 34,
  "journal-issue": {
    "issue": "4962",
    "published-print": {
      "date-parts": [
        [
          1990,
          6,
          22
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1126/science.1694307"
  ],
  "URL": "http://dx.doi.org/10.1126/science.1694307",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1990,
        6,
        22
      ]
    ]
  }
}