DOI: 10.1126/science.169.3944.490. Cyclic Adenosine Monophosphate: Potassium-Dependent Action on Vascular Smooth Muscle Membrane Potential [Penn]

Cyclic Adenosine Monophosphate: Potassium-Dependent Action on Vascular Smooth Muscle Membrane Potential

10.1126/science.169.3944.490

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Dibutyryl cyclic adenosine monophosphate and theophylline hyperpolarize smooth muscle of rabbit main pulmonary artery in low concentrations of potassium (1 millimole per liter) but do not have a significant effect on the membrane potential in the presence of high concentrations of potassium (10 millimoles per liter). The dependence of the hyperpolarizing effect on a low external concentration of potassium is similar to that observed with isoproterenol. Prior treatment with theophylline potentiated the hyperpolarizing action of isoproterenol. These findings are compatible with the assumption that potassium-dependent, beta-adrenergic hyperpolarization is mediated by cyclic adenosine monophosphate.

Bibliography

Somlyo, A. V., Haeusler, G., & Somlyo, A. P. (1970). Cyclic Adenosine Monophosphate: Potassium-Dependent Action on Vascular Smooth Muscle Membrane Potential. Science, 169(3944), 490â491.

Authors 3

Avril V. Somlyo (first)
G. Haeusler (additional)
A. P. Somlyo (additional)

References 8 Referenced 50

Robison, G. A., Fundamental Concepts in Drug-Receptor Interactions: 59 (1970). / Fundamental Concepts in Drug-Receptor Interactions (1970)
Somlyo, A. P., Pharmacol. Rev. 22: 249 (1970). / Pharmacol. Rev. (1970)
10.1126/science.165.3897.1018
Diamond, J., J. Pharmacol. Exp. Ther. 168: 13 (1969). / J. Pharmacol. Exp. Ther. (1969)
Somlyo, A. P., Fed. Proc. 28: 1634 (1969). / Fed. Proc. (1969)
Somlyo, A. V., Fed. Proc. 29: 613 (1970). / Fed. Proc. (1970)
Johansson, B., Circ. Res. 21: 619 (1967). (10.1161/01.RES.21.5.619) / Circ. Res. (1967)
Somlyo, A. V., Microvasc. Res. 1: 354 (1969). (10.1016/0026-2862(69)90014-4) / Microvasc. Res. (1969)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 8:56 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 11:47 a.m.)
Indexed	1 year, 2 months ago (June 17, 2024, 4:27 p.m.)
Issued	55 years, 1 month ago (July 31, 1970)
Published	55 years, 1 month ago (July 31, 1970)
Published Print	55 years, 1 month ago (July 31, 1970)

Funders 0

None

BibTeX

@article{Somlyo_1970, title={Cyclic Adenosine Monophosphate: Potassium-Dependent Action on Vascular Smooth Muscle Membrane Potential}, volume={169}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.169.3944.490}, DOI={10.1126/science.169.3944.490}, number={3944}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Somlyo, Avril V. and Haeusler, G. and Somlyo, A. P.}, year={1970}, month=jul, pages={490–491} }

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