DOI: 10.1126/science.169.3943.339. Cyclic Adenosine Monophosphate in Bacteria

Cyclic Adenosine Monophosphate in Bacteria

10.1126/science.169.3943.339

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Both cyclic AMP and a specific inducer acting in concert are required for the synthesis of many inducible enzymes in E. coli. Little enzyme is made in the absence of either. In contrast to the specific inducers which stimulate the synthesis only of the proteins required for their metabolism, cyclic AMP controls the synthesis of many proteins. Glucose and certain other carbohydrates decrease the differential rate of synthesis of inducible enzymes by lowering cyclic AMP concentrations. In the lac operon, cyclic AMP acts at the promoter site to facilitate initiation of transcription. This action requires another protein, the cyclic AMP receptor protein. The nucleotide stimulates tryptophanase synthesis at a translational level. The action of cyclic AMP in E. coli may serve as a model to understand its action on transcriptional and translational processes in eukaryotes.

Bibliography

Pastan, I., & Perlman, R. (1970). Cyclic Adenosine Monophosphate in Bacteria. Science, 169(3943), 339â344.

Authors 2

Ira Pastan (first)
Robert Perlman (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 8:56 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 11:45 a.m.)
Indexed	3 weeks, 5 days ago (Aug. 6, 2025, 8:33 a.m.)
Issued	55 years, 1 month ago (July 24, 1970)
Published	55 years, 1 month ago (July 24, 1970)
Published Print	55 years, 1 month ago (July 24, 1970)

Funders 0

None

BibTeX

@article{Pastan_1970, title={Cyclic Adenosine Monophosphate in Bacteria: In many bacteria the synthesis of inducible enzymes requires this cyclic nucleotide.}, volume={169}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.169.3943.339}, DOI={10.1126/science.169.3943.339}, number={3943}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Pastan, Ira and Perlman, Robert}, year={1970}, month=jul, pages={339–344} }

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