DOI: 10.1126/science.1683003. Activation of Early Gene Expression in T Lymphocytes by Oct-1 and an Inducible Protein, OAP <sup>40</sup>

Activation of Early Gene Expression in T Lymphocytes by Oct-1 and an Inducible Protein, OAP 40

10.1126/science.1683003

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

After antigenic stimulation of T lymphocytes, genes essential for proliferation and immune function, such as the interleukin-2 (IL-2) gene, are transcriptionally activated. In both transient transfections and T lymphocyte-specific in vitro transcription, the homeodomain-containing protein Oct-1 participated in the inducible regulation of transcription of the IL-2 gene. Oct-1 functioned in this context with a 40-kilodalton protein called Oct-1-associated protein (OAP 40 ). In addition to interacting specifically with DNA, OAP 40 reduced the rate of dissociation of Oct-1 from its cognate DNA-binding site, suggesting that a direct interaction exists between Oct-1 and OAP 40 .

Bibliography

Ullman, K. S., Flanagan, W. M., Edwards, C. A., & Crabtree, G. R. (1991). Activation of Early Gene Expression in T Lymphocytes by Oct-1 and an Inducible Protein, OAP 40. Science, 254(5031), 558â562.

Authors 4

Katharine S. Ullman (first)
W. Michael Flanagan (additional)
Cynthia A. Edwards (additional)
Gerald R. Crabtree (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 11:44 a.m.)
Indexed	1 month, 3 weeks ago (July 11, 2025, 6:26 a.m.)
Issued	33 years, 10 months ago (Oct. 25, 1991)
Published	33 years, 10 months ago (Oct. 25, 1991)
Published Print	33 years, 10 months ago (Oct. 25, 1991)

Funders 0

None

BibTeX

@article{Ullman_1991, title={Activation of Early Gene Expression in T Lymphocytes by Oct-1 and an Inducible Protein, OAP 40}, volume={254}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1683003}, DOI={10.1126/science.1683003}, number={5031}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Ullman, Katharine S. and Flanagan, W. Michael and Edwards, Cynthia A. and Crabtree, Gerald R.}, year={1991}, month=oct, pages={558–562} }

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