DOI: 10.1126/science.1681588. Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones

Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones

10.1126/science.1681588

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced predominantly interferon-γ, whereas those clones that enhanced antibody formation produced interleukin-4. CD8 cytotoxic T cells secreted interferon-γ. Interleukin-4 was produced by CD8 T suppressor clones from immunologically unresponsive individuals with leprosy and was found to be necessary for suppression in vitro. Both the classic reciprocal relation between antibody formation and cell-mediated immunity and resistance or susceptibility to certain infections may be explained by T cell subsets differing in patterns of lymphokine production.

Bibliography

Salgame, P., Abrams, J. S., Clayberger, C., Goldstein, H., Convit, J., Modlin, R. L., & Bloom, B. R. (1991). Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones. Science, 254(5029), 279â282.

Authors 7

Padmini Salgame (first)
John S. Abrams (additional)
Carol Clayberger (additional)
Harris Goldstein (additional)
Jacinto Convit (additional)
Robert L. Modlin (additional)
Barry R. Bloom (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 9:06 a.m.)
Indexed	4 months, 3 weeks ago (April 8, 2025, 10:19 p.m.)
Issued	33 years, 10 months ago (Oct. 11, 1991)
Published	33 years, 10 months ago (Oct. 11, 1991)
Published Print	33 years, 10 months ago (Oct. 11, 1991)

Funders 0

None

BibTeX

@article{Salgame_1991, title={Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones}, volume={254}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1681588}, DOI={10.1126/science.1681588}, number={5029}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Salgame, Padmini and Abrams, John S. and Clayberger, Carol and Goldstein, Harris and Convit, Jacinto and Modlin, Robert L. and Bloom, Barry R.}, year={1991}, month=oct, pages={279–282} }

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