DOI: 10.1126/science.168.3935.1095. Cross-Reactions between Streptococcal M Proteins and Human Transplantation Antigens

Cross-Reactions between Streptococcal M Proteins and Human Transplantation Antigens

10.1126/science.168.3935.1095

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Allogeneic antiserums against human lymphocytes were specifically inhibited by M protein from beta hemolytic group A Streptococcus pyogenes , type 1. Analogous M proteins from streptococcus types 3, 4, 5, 6, 12, and 14 had little or no inhibitory activity. The specific inhibition by M protein is not a result of anticomplementary activity or of coating of the lymphocyte surface. Streptococcal polysaccharide and 73 other polysaccharides were inactive. Because all seven HL-A specificities tested were inhibited, it is inferred that M1 protein has a structure common to human histocompatibility antigens.

Bibliography

Hirata, A. A., & Terasaki, P. I. (1970). Cross-Reactions between Streptococcal M Proteins and Human Transplantation Antigens. Science, 168(3935), 1095â1096.

Authors 2

Arthur A. Hirata (first)
Paul I. Terasaki (additional)

References 22 Referenced 96

ASHERSON, G.L., PROGR ALLERG 9: 192 (1965). / PROGR ALLERG (1965)
BLEIWEIS, A.S., IMPROVED TECHNIQUE FOR PREPARATION OF STREPTOCOCCAL CELL WALLS, JOURNAL OF BACTERIOLOGY 88: 1198 (1964). (10.1128/jb.88.4.1198-1200.1964) / JOURNAL OF BACTERIOLOGY (1964)
ENANUE, E.R., ADVAN IMMUNOL 6: 1 (1967). (10.1016/S0065-2776(08)60521-0) / ADVAN IMMUNOL (1967)
FOX, E.N., ANTIGENICITY OF M PROTEINS OF GROUP A HEMOLYTIC STREPTOCOCCI .3. ANTIBODY RESPONSES AND CUTANEOUS HYPERSENSITIVITY IN HUMANS, JOURNAL OF EXPERIMENTAL MEDICINE 124: 1135 (1966). (10.1084/jem.124.6.1135) / JOURNAL OF EXPERIMENTAL MEDICINE (1966)
FULLER, A.T., The formamide method for the extraction of polysaccharides from haemolytic streptococci., BRITISH JOURNAL OF EXPERIMENTAL PATHOLOGY 19: 130 (1938). / BRITISH JOURNAL OF EXPERIMENTAL PATHOLOGY (1938)
HIGGINS, P.M., ACUTE NEPHRITIS AND STREPTOCOCCAL SORE THROAT - A PROSPECTIVE STUDY IN GENERAL PRACTICE, BRITISH MEDICAL JOURNAL 2: 1156 (1965). (10.1136/bmj.2.5471.1156) / BRITISH MEDICAL JOURNAL (1965)
10.1126/science.164.3879.514
KAPLAN, M.H., IMMUNOLOGIC RELATION OF STREPTOCOCCAL + TISSUE ANTIGENS .2. CROSS-REACTION OF ANTISERA TO MAMMALIAN HEART TISSUE WITH CELL WALL CONSTITUENT OF CERTAIN STRAINS OF GROUP A STREPTOCOCCI, JOURNAL OF EXPERIMENTAL MEDICINE 119: 643 (1964). (10.1084/jem.119.4.643) / JOURNAL OF EXPERIMENTAL MEDICINE (1964)
KAPLAN, M.H., IMMUNOLOGIC STUDIES OF HEART TISSUE .5. ANTIGENS RELATED TO HEART TISSUE REVEALED BY CROSS-REACTION OF RABBIT ANTISERA TO HETEROLOGOUS HEART, JOURNAL OF IMMUNOLOGY 88: 450 (1962). (10.4049/jimmunol.88.4.450) / JOURNAL OF IMMUNOLOGY (1962)
MARKOWITZ, A.S., STREPTOCOCCAL RELATED GLOMERULONEPHRITIS .1. ISOLATION IMMUNOCHEMISTRY + COMPARATIVE CHEMISTRY OF SOLUBLE FRACTIONS FROM TYPE 12 NEPHRITOGENIC STREPTOCOCCI + HUMAN GLOMERULI, JOURNAL OF IMMUNOLOGY 92: 565 (1964). (10.4049/jimmunol.92.4.565) / JOURNAL OF IMMUNOLOGY (1964)
PATEL, R, LEUCOCYTE ANTIGENS AND DISEASE .1. ASSOCIATION OF HL-A2 AND CHRONIC GLOMERULONEPHRITIS, BRITISH MEDICAL JOURNAL 2: 424 (1969). (10.1136/bmj.2.5654.424) / BRITISH MEDICAL JOURNAL (1969)
Rapaport F. T. Histocompatibility Testing 1965 (1965).
RAPAPORT, F.T., BACTERIAL INDUCTION OF HOMOGRAFT SENSITIVITY .3. EFFECTS OF GROUP A STREPTOCOCCAL MEMBRANE ANTISERA, JOURNAL OF EXPERIMENTAL MEDICINE 129: 623 (1969). (10.1084/jem.129.4.623) / JOURNAL OF EXPERIMENTAL MEDICINE (1969)
ROWLEY, D, ANTIGENIC CROSS-REACTION BETWEEN HOST AND PARASITE AS A POSSIBLE CAUSE OF PATHOGENICITY, NATURE 193: 151 (1962). (10.1038/193151a0) / NATURE (1962)
Springer, G. F., Cross-Reacting Antigens and Neoantigens: 29 (1967). / Cross-Reacting Antigens and Neoantigens (1967)
SPRINGER, G.F., BLOOD GROUP ACTIVITY OF GRAM-NEGATIVE BACTERIA, JOURNAL OF EXPERIMENTAL MEDICINE 113: 1077 (1961). (10.1084/jem.113.6.1077) / JOURNAL OF EXPERIMENTAL MEDICINE (1961)
TERASAKI, P.I., HUMAN HISTOCOMPATIBILITY ANTIGENS OF LEUKOCYTES, ANNUAL REVIEW OF MEDICINE 20: 175 (1969). (10.1146/annurev.me.20.020169.001135) / ANNUAL REVIEW OF MEDICINE (1969)
Trentin, J. J., Cross-Reacting Antigens and Neoantigens: R11 (1967). / Cross-Reacting Antigens and Neoantigens (1967)
10.1126/science.152.3719.172
Weigle W. O. Natural and Acquired Immunologic Unresponsiveness (1967).
ZABRISKIE, J.B., ADVANCES IN IMMUNOLOGY 7: 147 (1967). (10.1016/S0065-2776(08)60128-5) / ADVANCES IN IMMUNOLOGY (1967)
ZITTLE, C.A., The antigenic structure of hemolytic streptococci of Lancefield Group A X. The purification and certain properties of the group-specific polysaccharide, JOURNAL OF BIOLOGICAL CHEMISTRY 142: 823 (1942). (10.1016/S0021-9258(18)45080-6) / JOURNAL OF BIOLOGICAL CHEMISTRY (1942)

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 8:56 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 10:34 a.m.)
Indexed	2 days, 16 hours ago (Sept. 4, 2025, 10:04 a.m.)
Issued	55 years, 3 months ago (May 29, 1970)
Published	55 years, 3 months ago (May 29, 1970)
Published Print	55 years, 3 months ago (May 29, 1970)

Funders 0

None

BibTeX

@article{Hirata_1970, title={Cross-Reactions between Streptococcal M Proteins and Human Transplantation Antigens}, volume={168}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.168.3935.1095}, DOI={10.1126/science.168.3935.1095}, number={3935}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Hirata, Arthur A. and Terasaki, Paul I.}, year={1970}, month=may, pages={1095–1096} }

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