DOI: 10.1126/science.167.3915.182. Adenohypophysial Transmembrane Potentials: Polarity Reversal by Elevated External Potassium Ion Concentration

Adenohypophysial Transmembrane Potentials: Polarity Reversal by Elevated External Potassium Ion Concentration

10.1126/science.167.3915.182

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Incubation of rat adenohypophyses in potassium ion of sufficient concentration to provoke the release of several of the adenohypophysial trophic hormones produces a reversed, positive transmembrane potential in more than half the cells. This finding is consistent with a process of "stimulus-secretion coupling" in which hypothalamic releasing factors act by selective depolarization of their "target" cells. The positive potentials may be due to a prolonged preferential permeability to calcium ions triggered by an initial depolarization of the cell membrane to a threshold value by increased external potassium ion.

Bibliography

Milligan, J. V., & Kraicer, J. (1970). Adenohypophysial Transmembrane Potentials: Polarity Reversal by Elevated External Potassium Ion Concentration. Science, 167(3915), 182â184.

Authors 2

J. V. Milligan (first)
Jacob Kraicer (additional)

References 11 Referenced 20

DOUGLAS, W.W., STIMULUS-SECRETION COUPLING - CONCEPT AND CLUES FROM CHROMAFFIN AND OTHER CELLS, BRITISH JOURNAL OF PHARMACOLOGY 34: 451 (1968). (10.1111/j.1476-5381.1968.tb08474.x) / BRITISH JOURNAL OF PHARMACOLOGY (1968)
HODGKIN, A.L., IONIC MOVEMENTS AND ELECTRICAL ACTIVITY IN GIANT NERVE FIBRES, PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 148: 1 (1958). / PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES (1958)
KRAICER, J, ADENOHYPOPHYSIAL DNA AND RNA AFTER ADRENALECTOMY CASTRATION AND PTU, AMERICAN JOURNAL OF PHYSIOLOGY 214: 158 (1968). (10.1152/ajplegacy.1968.214.1.158) / AMERICAN JOURNAL OF PHYSIOLOGY (1968)
10.1126/science.164.3878.426
LING, G, NATURE 165: 133 (1950). / NATURE (1950)
MILLIGAN J.V. UNPUBLISHED RESULTS.
SAMLI, M.H., SOME EFFECTS OF ENERGY-TRANSFER INHIBITORS AND OF CA++-FREE OR K+-ENHANCED MEDIA ON RELEASE OF LUTEINIZING HORMONE (LH) FROM RAT PITUITARY GLAND IN VITRO, ENDOCRINOLOGY 82: 225 (1968). (10.1210/endo-82-2-225) / ENDOCRINOLOGY (1968)
Umbreit, W. W., Manometric Techniques: 132 (1964). / Manometric Techniques (1964)
VALE, W, POTASSIUM-INDUCED STIMULATION OF THYROTROPIN RELEASE IN VITRO - REQUIREMENT FOR PRESENCE OF CALCIUM AND INHIBITION BY THYROXINE, EXPERIENTIA 23: 855 (1967). (10.1007/BF02146888) / EXPERIENTIA (1967)
WEBER, A, ON MECHANISM OF RELAXING EFFECT OF FRAGMENTED SARCOPLASMIC RETICULUM, JOURNAL OF GENERAL PHYSIOLOGY 46: 679 (1963). (10.1085/jgp.46.4.679) / JOURNAL OF GENERAL PHYSIOLOGY (1963)
Wilde W. S. Mineral Metabolism 2A (1962).

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 8:56 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 10:42 a.m.)
Indexed	1 year, 7 months ago (Jan. 11, 2024, 7:04 p.m.)
Issued	55 years, 7 months ago (Jan. 9, 1970)
Published	55 years, 7 months ago (Jan. 9, 1970)
Published Print	55 years, 7 months ago (Jan. 9, 1970)

Funders 0

None

BibTeX

@article{Milligan_1970, title={Adenohypophysial Transmembrane Potentials: Polarity Reversal by Elevated External Potassium Ion Concentration}, volume={167}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.167.3915.182}, DOI={10.1126/science.167.3915.182}, number={3915}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Milligan, J. V. and Kraicer, Jacob}, year={1970}, month=jan, pages={182–184} }

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