DOI: 10.1126/science.1661031. Targeting of the Master Receptor MOM19 to Mitochondria

Targeting of the Master Receptor MOM19 to Mitochondria

10.1126/science.1661031

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The targeting of proteins to mitochondria involves the recognition of the precursor proteins by receptors on the mitochondrial surface followed by insertion of the precursors into the outer membrane at the general insertion site GIP. Most mitochondrial proteins analyzed so far use a mitochondrial outer membrane protein of 19 kilodaltons (MOM19) as an import receptor. The gene encoding MOM19 has now been isolated. The deduced amino acid sequence predicts that MOM19 is anchored in the outer membrane by an NH 2 -terminal hydrophobic sequence, while the rest of the protein forms a hydrophilic domain exposed to the cytosol. MOM19 was targeted to the mitochondria via a pathway that is independent of protease-accessible surface receptors and controlled by direct assembly of the MOM19 precursor with GIP.

Bibliography

Schneider, H., SÃ¶llner, T., Dietmeier, K., Eckerskorn, C., Lottspeich, F., TrÃ¼lzsch, B., Neupert, W., & Pfanner, N. (1991). Targeting of the Master Receptor MOM19 to Mitochondria. Science, 254(5038), 1659â1662.

Authors 8

Helmut Schneider (first)
Thomas Söllner (additional)
Klaus Dietmeier (additional)
Christoph Eckerskorn (additional)
Fritz Lottspeich (additional)
Barbara Trülzsch (additional)
Walter Neupert (additional)
Nikolaus Pfanner (additional)

References 29 Referenced 94

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10.1126/science.6356359

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 11:47 a.m.)
Indexed	1 year, 7 months ago (Jan. 11, 2024, 7:04 p.m.)
Issued	33 years, 8 months ago (Dec. 13, 1991)
Published	33 years, 8 months ago (Dec. 13, 1991)
Published Print	33 years, 8 months ago (Dec. 13, 1991)

Funders 0

None

BibTeX

@article{Schneider_1991, title={Targeting of the Master Receptor MOM19 to Mitochondria}, volume={254}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1661031}, DOI={10.1126/science.1661031}, number={5038}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Schneider, Helmut and Söllner, Thomas and Dietmeier, Klaus and Eckerskorn, Christoph and Lottspeich, Fritz and Trülzsch, Barbara and Neupert, Walter and Pfanner, Nikolaus}, year={1991}, month=dec, pages={1659–1662} }

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