DOI: 10.1126/science.166.3912.1535. Peroxidation of Subcellular Organelles: Formation of Lipofuscinlike Fluorescent Pigments

Peroxidation of Subcellular Organelles: Formation of Lipofuscinlike Fluorescent Pigments

10.1126/science.166.3912.1535

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Lipid peroxidation of subcellular organelles gives fluorescent products which have fluorescence and excitation spectra similar to those of lipofuscin pigments. Fluorescence and excitation spectra and total fluorescence in the 460-nanometer region are useful for qualitative identification and quantitative measurement of the Schiff base product, a molecular damage site of lipid peroxidation which develops during some aging processes.

Bibliography

Chio, K. S., Reiss, U., Fletcher, B., & Tappel, A. L. (1969). Peroxidation of Subcellular Organelles: Formation of Lipofuscinlike Fluorescent Pigments. Science, 166(3912), 1535â1536.

Authors 4

K. S. Chio (first)
U. Reiss (additional)
B. Fletcher (additional)
A. L. Tappel (additional)

References 20 Referenced 167

BARBER, A.A., ADV GERONTOL RES 2: 355 (1967). / ADV GERONTOL RES (1967)
CHIO, K.S., SYNTHESIS AND CHARACTERIZATION OF FLUORESCENT PRODUCTS DERIVED FROM MALONALDEHYDE AND AMINO ACIDS, BIOCHEMISTRY 8: 2821 (1969). (10.1021/bi00835a019) / BIOCHEMISTRY (1969)
10.1021/bi00835a020
DESAI, I.D., PEROXIDATIVE + RADIATION DAMAGE TO ISOLATED LYSOSOMES, BIOCHIMICA ET BIOPHYSICA ACTA 86: 277 (1964). (10.1016/0304-4165(64)90054-6) / BIOCHIMICA ET BIOPHYSICA ACTA (1964)
DESAI, I.D., DAMAGE TO PROTEINS BY PEROXIDIZED LIPIDS, JOURNAL OF LIPID RESEARCH 4: 204 (1963). (10.1016/S0022-2275(20)40348-7) / JOURNAL OF LIPID RESEARCH (1963)
HARMAN, D, FREE RADICAL THEORY OF AGING - EFFECT OF FREE RADICAL REACTION INHIBITORS ON MORTALITY RATE OF MALE LAF1 MICE, JOURNALS OF GERONTOLOGY 23: 476 (1968). (10.1093/geronj/23.4.476) / JOURNALS OF GERONTOLOGY (1968)
Hartroft, W. S., Present Knowledge in Nutrition: 28 (1967). / Present Knowledge in Nutrition (1967)
HAUGAARD, N, CELLULAR MECHANISMS OF OXYGEN TOXICITY, PHYSIOLOGICAL REVIEWS 48: 311 (1968). (10.1152/physrev.1968.48.2.311) / PHYSIOLOGICAL REVIEWS (1968)
HENDLEY, D. D., JOURNALS OF GERONTOLOGY 18: 144 (1963). (10.1093/geronj/18.2.144) / JOURNALS OF GERONTOLOGY (1963)
HYDEN, H, MICROSPECTROGRAPHIC STUDIES ON THE YELLOW PIGMENT IN NERVE CELLS, DISCUSSIONS OF THE FARADAY SOCIETY 9: 436 (1950). (10.1039/DF9500900436) / DISCUSSIONS OF THE FARADAY SOCIETY (1950)
PACKER, L, Advances in Gerontological Research 2: 77 (1967). / Advances in Gerontological Research (1967)
RAGAB, H, PREPARATION OF RAT LIVER LYSOSOMES, BIOCHIMICA ET BIOPHYSICA ACTA 148: 501 (1967). (10.1016/0304-4165(67)90148-1) / BIOCHIMICA ET BIOPHYSICA ACTA (1967)
RAGAB, M.H., HYDROLYSIS OF FLAVIN-ADENINE DINUCLEOTIDE BY RAT LIVER LYSOSOMES, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 123: 179 (1968). (10.1016/0003-9861(68)90117-3) / ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (1968)
RECKNAGEL, R.O., CARBON TETRACHLORIDE HEPATOTOXICITY, PHARMACOLOGICAL REVIEWS 19: 145 (1967). / PHARMACOLOGICAL REVIEWS (1967)
ROBINSON, J.D., STRUCTURAL CHANGES IN MICROSOMAL SUSPENSIONS .3. FORMATION OF LIPID PEROXIDES, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 112: 170 (1965). (10.1016/0003-9861(65)90025-1) / ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (1965)
SCHNEIDER, A.K., CORRELATION OF OXYGEN CONSUMPTION WITH SWELLING + LIPID PEROXIDE FORMATION WHEN MITOCHONDRIA ARE TREATED WITH SWELLING-INDUCING AGENTS FE2+ GLUTATHIONE ASCORBATE OR PHOSPHATE, BIOCHEMISTRY 3: 1470 (1964). (10.1021/bi00898a014) / BIOCHEMISTRY (1964)
SLATER, T.F., NECROGENIC ACTION OF CARBON TETRACHLORIDE IN RAT - A SPECULATIVE MECHANISM BASED ON ACTIVATION, NATURE 209: 36 (1966). (10.1038/209036a0) / NATURE (1966)
TAPPEL, A.L., FREE-RADICAL LIPID PEROXIDATION DAMAGE AND ITS INHIBITION BY VITAMIN E AND SELENIUM, FEDERATION PROCEEDINGS 24: 73 (1965). / FEDERATION PROCEEDINGS (1965)
TAPPEL, A.L., WILL ANTIOXIDANT NUTRIENTS SLOW AGING PROCESSES, GERIATRICS 23: 97 (1968). / GERIATRICS (1968)
Wolman, M., Handbuch der Histochemie 5: 96 (1964). / Handbuch der Histochemie (1964)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 8:14 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 11:32 a.m.)
Indexed	3 months ago (May 26, 2025, 4:05 a.m.)
Issued	55 years, 8 months ago (Dec. 19, 1969)
Published	55 years, 8 months ago (Dec. 19, 1969)
Published Print	55 years, 8 months ago (Dec. 19, 1969)

Funders 0

None

BibTeX

@article{Chio_1969, title={Peroxidation of Subcellular Organelles: Formation of Lipofuscinlike Fluorescent Pigments}, volume={166}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.166.3912.1535}, DOI={10.1126/science.166.3912.1535}, number={3912}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Chio, K. S. and Reiss, U. and Fletcher, B. and Tappel, A. L.}, year={1969}, month=dec, pages={1535–1536} }

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