DOI: 10.1126/science.166.3901.122. Phosphonomycin, a New Antibiotic Produced by Strains of <i>Streptomyces</i>

Phosphonomycin, a New Antibiotic Produced by Strains of Streptomyces

10.1126/science.166.3901.122

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Phosphonomycin is a newly discovered antibiotic produced by streptomycetes. It is effective, when administered by the oral route, to mice infected with Gram-positive or Gram-negative microorganisms. The antibiotic is bactericidal and inhibits cell-wall synthesis.

Bibliography

Hendlin, D., Stapley, E. O., Jackson, M., Wallick, H., Miller, A. K., Wolf, F. J., Miller, T. W., Chaiet, L., Kahan, F. M., Foltz, E. L., Woodruff, H. B., Mata, J. M., Hernandez, S., & Mochales, S. (1969). Phosphonomycin, a New Antibiotic Produced by Strains of Streptomyces. Science, 166(3901), 122â123.

Authors 14

D. Hendlin (first)
E. O. Stapley (additional)
M. Jackson (additional)
H. Wallick (additional)
A. K. Miller (additional)
F. J. Wolf (additional)
T. W. Miller (additional)
L. Chaiet (additional)
F. M. Kahan (additional)
E. L. Foltz (additional)
H. B. Woodruff (additional)
J. M. Mata (additional)
S. Hernandez (additional)
S. Mochales (additional)

References 10 Referenced 468

CHAIET L IN PREPARATION.
10.1126/science.166.3901.123
FOLTZ E.L. IN PREPARATION.
GUNETILEKE, K.G., BIOSYNTHESIS OF URIDINE DIPHOSPHO-N-ACETYLMURAMIC ACID .2. PURIFICATION AND PROPERTIES OF PYRUVATE-URIDINE DIPHOSPHO-N-ACETYLGLUCOSAMINE TRANSFERASE AND CHARACTERIZATION OF URIDINE DIPHOSPHO-N-ACETYLENOLPYRUVYLGLUCOSAMINE, JOURNAL OF BIOLOGICAL CHEMISTRY 243: 5770 (1968). (10.1016/S0021-9258(18)91931-9) / JOURNAL OF BIOLOGICAL CHEMISTRY (1968)
KAHAN F.M. IN PREPARATION.
KOCH, J.P., CONTROL OF DISSIMILATION OF GLYCEROL + L-ALPHA-GLYCEROPHOSPHATE IN ESCHERICHIA COLI, JOURNAL OF BIOLOGICAL CHEMISTRY 239: 3106 (1964). (10.1016/S0021-9258(18)93859-7) / JOURNAL OF BIOLOGICAL CHEMISTRY (1964)
MILLER, A.K., ANTIBACTERIAL CHEMOTHERAPY TESTS - INFLUENCE OF CHALLENGE PREPARATION + OF DOSAGE SCHEDULE ON IN VIVO EFFECTIVENESS OF BACTERIOSTATIC + BACTERICIDAL ANTIBIOTIC, CHEMOTHERAPY 8: 154 (1964). (10.1159/000220306) / CHEMOTHERAPY (1964)
STAPLEY, E.O., CROSS-RESISTANCE STUDIES AND ANTIBIOTIC IDENTIFICATION, APPLIED MICROBIOLOGY 6: 392 (1958). (10.1128/am.6.6.392-398.1958) / APPLIED MICROBIOLOGY (1958)
STROMINGER, J.L., ENZYMIC TRANSFER OF PYRUVATE TO URIDINE DIPHOSPHOACETYLGLUCOSAMINE, BIOCHIMICA ET BIOPHYSICA ACTA 30: 645 (1958). (10.1016/0006-3002(58)90119-7) / BIOCHIMICA ET BIOPHYSICA ACTA (1958)
VINCENT, J.G., Filter paper disc modification of the Oxford cup penicillin determination, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 55: 162 (1944). (10.3181/00379727-55-14502) / PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE (1944)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 8:14 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 9:18 a.m.)
Indexed	3 weeks, 5 days ago (Aug. 2, 2025, 12:23 a.m.)
Issued	55 years, 10 months ago (Oct. 3, 1969)
Published	55 years, 10 months ago (Oct. 3, 1969)
Published Print	55 years, 10 months ago (Oct. 3, 1969)

Funders 0

None

BibTeX

@article{Hendlin_1969, title={Phosphonomycin, a New Antibiotic Produced by Strains of Streptomyces}, volume={166}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.166.3901.122}, DOI={10.1126/science.166.3901.122}, number={3901}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Hendlin, D. and Stapley, E. O. and Jackson, M. and Wallick, H. and Miller, A. K. and Wolf, F. J. and Miller, T. W. and Chaiet, L. and Kahan, F. M. and Foltz, E. L. and Woodruff, H. B. and Mata, J. M. and Hernandez, S. and Mochales, S.}, year={1969}, month=oct, pages={122–123} }

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