DOI: 10.1126/science.1654594. Excitatory Synaptic Responses Mediated by GABA <sub>A</sub> Receptors in the Hippocampus

Excitatory Synaptic Responses Mediated by GABA A Receptors in the Hippocampus

10.1126/science.1654594

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the cortex. Activation of postsynaptic GABA A receptors hyperpolarizes cells and inhibits neuronal activity. Synaptic responses mediated by GABA A receptors also strongly excited hippocampal neurons. This excitatory response was recorded in morphologically identified interneurons in the presence of 4-aminopyridine or after elevation of extracellular potassium concentrations. The synaptic excitation sustained by GABA A receptors synchronized the activity of inhibitory interneurons. This synchronized discharge of interneurons in turn elicited large-amplitude inhibitory postsynaptic potentials in pyramidal and granule cells. Excitatory synaptic responses mediated by GABA A receptors may thus provide a mechanism for the recruitment of GABAergic interneurons through their recurrent connections.

Bibliography

Michelson, H. B., & Wong, R. K. S. (1991). Excitatory Synaptic Responses Mediated by GABA A Receptors in the Hippocampus. Science, 253(5026), 1420â1423.

Authors 2

Hillary B. Michelson (first)
Robert K. S. Wong (additional)

References 25 Referenced 211

ALGER, B.E., FEEDFORWARD DENDRITIC INHIBITION IN RAT HIPPOCAMPAL PYRAMIDAL CELLS STUDIED INVITRO, JOURNAL OF PHYSIOLOGY-LONDON 328: 105 (1982). (10.1113/jphysiol.1982.sp014255) / JOURNAL OF PHYSIOLOGY-LONDON (1982)
ALGER, B.E., PHARMACOLOGICAL EVIDENCE FOR 2 KINDS OF GABA RECEPTOR ON RAT HIPPOCAMPAL PYRAMIDAL CELLS STUDIED INVITRO, JOURNAL OF PHYSIOLOGY-LONDON 328: 125 (1982). (10.1113/jphysiol.1982.sp014256) / JOURNAL OF PHYSIOLOGY-LONDON (1982)
ANDERSEN, P, PATHWAY OF POSTSYNAPTIC INHIBITION IN HIPPOCAMPUS, JOURNAL OF NEUROPHYSIOLOGY 27: 608 (1964). (10.1152/jn.1964.27.4.608) / JOURNAL OF NEUROPHYSIOLOGY (1964)
ANDERSEN, P, 2 DIFFERENT RESPONSES OF HIPPOCAMPAL PYRAMIDAL CELLS TO APPLICATION OF GAMMA-AMINO BUTYRIC-ACID, JOURNAL OF PHYSIOLOGY-LONDON 305: 279 (1980). (10.1113/jphysiol.1980.sp013363) / JOURNAL OF PHYSIOLOGY-LONDON (1980)
ARAM, J, Synaptic Events Persist in the Presence of Excitatory Amino Acid Receptor Blockade in Guinea-pig Neocortex in Vitro, BRITISH JOURNAL OF PHARMACOLOGY 96: 82P (1989). / BRITISH JOURNAL OF PHARMACOLOGY / Synaptic Events Persist in the Presence of Excitatory Amino Acid Receptor Blockade in Guinea-pig Neocortex in Vitro (1989)
ARAM, J.A., SYNCHRONIZED GABAERGIC IPSPS RECORDED IN THE NEOCORTEX AFTER BLOCKADE OF SYNAPTIC TRANSMISSION MEDIATED BY EXCITATORY AMINO-ACIDS, JOURNAL OF NEUROPHYSIOLOGY 65: 1034 (1991). (10.1152/jn.1991.65.5.1034) / JOURNAL OF NEUROPHYSIOLOGY (1991)
CHAGNACAMITAI, Y, SYNCHRONIZED EXCITATION AND INHIBITION DRIVEN BY INTRINSICALLY BURSTING NEURONS IN NEOCORTEX, JOURNAL OF NEUROPHYSIOLOGY 62: 1149 (1989). (10.1152/jn.1989.62.5.1149) / JOURNAL OF NEUROPHYSIOLOGY (1989)
10.1126/science.2899909
KNOWLES, W.D., LOCAL CIRCUIT SYNAPTIC-INTERACTIONS IN HIPPOCAMPAL BRAIN-SLICES, JOURNAL OF NEUROSCIENCE 1: 318 (1981). (10.1523/JNEUROSCI.01-03-00318.1981) / JOURNAL OF NEUROSCIENCE (1981)
KOSAKA, T, GABAERGIC NEURONS CONTAINING SOMATOSTATIN-LIKE IMMUNOREACTIVITY IN THE RAT HIPPOCAMPUS AND DENTATE GYRUS, EXPERIMENTAL BRAIN RESEARCH 71: 388 (1988). / EXPERIMENTAL BRAIN RESEARCH (1988)
LACAILLE, J.C., LOCAL CIRCUIT INTERACTIONS BETWEEN ORIENS-ALVEUS INTERNEURONS AND CA1 PYRAMIDAL CELLS IN HIPPOCAMPAL SLICES - ELECTROPHYSIOLOGY AND MORPHOLOGY, JOURNAL OF NEUROSCIENCE 7: 1979 (1987). (10.1523/JNEUROSCI.07-07-01979.1987) / JOURNAL OF NEUROSCIENCE (1987)
LACAILLE, J.C., STRATUM LACUNOSUM-MOLECULARE INTERNEURONS OF HIPPOCAMPAL CA1-REGION .2. INTRASOMATIC AND INTRADENDRITIC RECORDINGS OF LOCAL CIRCUIT SYNAPTIC-INTERACTIONS, JOURNAL OF NEUROSCIENCE 8: 1411 (1988). (10.1523/JNEUROSCI.08-04-01411.1988) / JOURNAL OF NEUROSCIENCE (1988)
LUX, H.D., ADVANCES IN NEUROLOGY 44: 619 (1986). / ADVANCES IN NEUROLOGY (1986)
MILES, R, INHIBITORY CONTROL OF LOCAL EXCITATORY CIRCUITS IN THE GUINEA-PIG HIPPOCAMPUS, JOURNAL OF PHYSIOLOGY-LONDON 388: 611 (1987). (10.1113/jphysiol.1987.sp016634) / JOURNAL OF PHYSIOLOGY-LONDON (1987)
MILES, R, Presynaptic fluctuations in efficacy of inhibitory synapses in the CA3 region of guinea-pig hippocampus in vitro, JOURNAL OF PHYSIOLOGY-LONDON 423: 95P (1990). / JOURNAL OF PHYSIOLOGY-LONDON / Presynaptic fluctuations in efficacy of inhibitory synapses in the CA3 region of guinea-pig hippocampus in vitro (1990)
MULLER, W, INHIBITORY ROLE OF DENTATE HILUS NEURONS IN GUINEA-PIG HIPPOCAMPAL SLICE, JOURNAL OF NEUROPHYSIOLOGY 64: 46 (1990). (10.1152/jn.1990.64.1.46) / JOURNAL OF NEUROPHYSIOLOGY (1990)
NICOLL, R.A., FUNCTIONAL COMPARISON OF NEUROTRANSMITTER RECEPTOR SUBTYPES IN MAMMALIAN CENTRAL-NERVOUS-SYSTEM, PHYSIOLOGICAL REVIEWS 70: 513 (1990). (10.1152/physrev.1990.70.2.513) / PHYSIOLOGICAL REVIEWS (1990)
PERREAULT, P, SOCIETY FOR NEUROSCIENCE. ABSTRACTS 15: 1213 (1989). / SOCIETY FOR NEUROSCIENCE. ABSTRACTS (1989)
SLOVITER, R.S., IMMUNOCYTOCHEMICAL LOCALIZATION OF GABA-, CHOLECYSTOKININ-LIKE, VASOACTIVE INTESTINAL POLYPEPTIDE-LIKE, AND SOMATOSTATIN-LIKE IMMUNOREACTIVITY IN THE AREA DENTATA AND HIPPOCAMPUS OF THE RAT, JOURNAL OF COMPARATIVE NEUROLOGY 256: 42 (1987). (10.1002/cne.902560105) / JOURNAL OF COMPARATIVE NEUROLOGY (1987)
SOMOGYI, P, DIFFERENT POPULATIONS OF GABAERGIC NEURONS IN THE VISUAL-CORTEX AND HIPPOCAMPUS OF CAT CONTAIN SOMATOSTATIN-IMMUNOREACTIVE OR CHOLECYSTOKININ-IMMUNOREACTIVE MATERIAL, JOURNAL OF NEUROSCIENCE 4: 2590 (1984). (10.1523/JNEUROSCI.04-10-02590.1984) / JOURNAL OF NEUROSCIENCE (1984)
STEWART, W.W., LUCIFER DYES - HIGHLY FLUORESCENT DYES FOR BIOLOGICAL TRACING, NATURE 292: 17 (1981). (10.1038/292017a0) / NATURE (1981)
10.1126/science.2646715
WATKINS, J.C., AGONISTS AND ANTAGONISTS FOR EXCITATORY AMINO-ACID RECEPTORS, TRENDS IN NEUROSCIENCES 10: 265 (1987). (10.1016/0166-2236(87)90171-8) / TRENDS IN NEUROSCIENCES (1987)
WONG, RKS, CELLULAR FACTORS INFLUENCING GABA RESPONSE IN HIPPOCAMPAL PYRAMIDAL CELLS, JOURNAL OF NEUROPHYSIOLOGY 48: 938 (1982). (10.1152/jn.1982.48.4.938) / JOURNAL OF NEUROPHYSIOLOGY (1982)
10.1126/science.7079735

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 11:30 a.m.)
Indexed	1 year, 2 months ago (June 22, 2024, 3:52 p.m.)
Issued	33 years, 11 months ago (Sept. 20, 1991)
Published	33 years, 11 months ago (Sept. 20, 1991)
Published Print	33 years, 11 months ago (Sept. 20, 1991)

Funders 0

None

BibTeX

@article{Michelson_1991, title={Excitatory Synaptic Responses Mediated by GABA A Receptors in the Hippocampus}, volume={253}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1654594}, DOI={10.1126/science.1654594}, number={5026}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Michelson, Hillary B. and Wong, Robert K. S.}, year={1991}, month=sep, pages={1420–1423} }

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  "alternative-id": [
    "10.1126/science.1654594"
  ],
  "URL": "http://dx.doi.org/10.1126/science.1654594",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1991,
        9,
        20
      ]
    ]
  }
}