DOI: 10.1126/science.165.3892.498. Vinblastine-Induced Precipitation of Microtubule Protein

Vinblastine-Induced Precipitation of Microtubule Protein

10.1126/science.165.3892.498

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Vinblastine quantitatively precipitates a protein from supernatants obtained from high-speed centrifugation of homogenates of HeLa cells and of pig brain. This protein migrates as a single band on gel electrophoresis, has a mobility identical to that of purified microtubule protein, and—like microtubule protein—binds colchicine. The precipitation is partially inhibited by 0.9 percent NaCl.

Bibliography

Marantz, R., Ventilla, M., & Shelanski, M. (1969). Vinblastine-Induced Precipitation of Microtubule Protein. Science, 165(3892), 498â499.

Authors 3

Robert Marantz (first)
Martha Ventilla (additional)
Michael Shelanski (additional)

References 10 Referenced 148

BENSCH, K.G., MICROTUBULAR CRYSTALS IN MAMMALIAN CELLS, JOURNAL OF CELL BIOLOGY 40: 95 (1969). (10.1083/jcb.40.1.95) / JOURNAL OF CELL BIOLOGY (1969)
BENSCH, K.G., MICROTUBULE CRYSTALS - A NEW BIOPHYSICAL PHENOMENON INDUCED BY VINCA ALKALOIDS, NATURE 218: 1176 (1968). (10.1038/2181176a0) / NATURE (1968)
CREASY, W.A., BINDING OF COLCHICINE BY SARCOMA 180 CELLS, BIOCHEMICAL PHARMACOLOGY 17: 477 (1968). (10.1016/0006-2952(68)90259-1) / BIOCHEMICAL PHARMACOLOGY (1968)
RENAUD, F.L., SOME PROPERTIES OF PROTEIN FORMING OUTER FIBERS OF CILIA, JOURNAL OF CELL BIOLOGY 36: 79 (1968). (10.1083/jcb.36.1.79) / JOURNAL OF CELL BIOLOGY (1968)
ROBBINS, E, HISTOCHEMICAL + ULTRASTRUCTURAL STUDIES ON HELA CELL CULTURES EXPOSED TO SPINDLE INHIBITORS WITH SPECIAL REFERENCE TO INTERPHASE CELL, JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 12: 704 (1964). (10.1177/12.9.704) / JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (1964)
ROSENBAUM J PERSONAL COMMUNICATION.
SHELANSKI, M.L., ISOLATION OF A PROTEIN SUBUNIT FROM MICROTUBULES, JOURNAL OF CELL BIOLOGY 34: 549 (1967). (10.1083/jcb.34.2.549) / JOURNAL OF CELL BIOLOGY (1967)
SHELANSKI, M.L., PROPERTIES OF PROTEIN SUBUNIT OF CENTRAL-PAIR AND OUTER-DOUBLET MICROTUBULES OF SEA URCHIN FLAGELLA, JOURNAL OF CELL BIOLOGY 38: 304 (1968). (10.1083/jcb.38.2.304) / JOURNAL OF CELL BIOLOGY (1968)
WEISENBERG, R.C., COLCHICINE-BINDING PROTEIN OF MAMMALIAN BRAIN AND ITS RELATION TO MICROTUBULES, BIOCHEMISTRY 7: 4466 (1968). (10.1021/bi00852a043) / BIOCHEMISTRY (1968)
WISNIEWSKI, H, EFFECTS OF MITOTIC SPINDLE INHIBITORS ON NEUROTUBULES AND NEUROFILAMENTS IN ANTERIOR HORN CELLS, JOURNAL OF CELL BIOLOGY 38: 224 (1968). (10.1083/jcb.38.1.224) / JOURNAL OF CELL BIOLOGY (1968)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 8:14 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 11:15 a.m.)
Indexed	1 year, 7 months ago (Jan. 11, 2024, 7:05 p.m.)
Issued	56 years, 1 month ago (Aug. 1, 1969)
Published	56 years, 1 month ago (Aug. 1, 1969)
Published Print	56 years, 1 month ago (Aug. 1, 1969)

Funders 0

None

BibTeX

@article{Marantz_1969, title={Vinblastine-Induced Precipitation of Microtubule Protein}, volume={165}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.165.3892.498}, DOI={10.1126/science.165.3892.498}, number={3892}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Marantz, Robert and Ventilla, Martha and Shelanski, Michael}, year={1969}, month=aug, pages={498–499} }

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