DOI: 10.1126/science.1646484. Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation

Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation

10.1126/science.1646484

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Basic fibroblast growth factor (bFGF) binds to heparan sulfate proteoglycans at the cell surface and to receptors with tyrosine kinase activity. Prevention of binding between cell surface heparan sulfate and bFGF (i) substantially reduces binding of fibroblast growth factor to its cell-surface receptors, (ii) blocks the ability of bFGF to support the growth of Swiss 3T3 fibroblasts, and (iii) induces terminal differentiation of MM14 skeletal muscle cells, which is normally repressed by fibroblast growth factor. These results indicate that cell surface heparan sulfate is directly involved in bFGF cell signaling.

Bibliography

Rapraeger, A. C., Krufka, A., & Olwin, B. B. (1991). Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation. Science, 252(5013), 1705â1708.

Authors 3

Alan C. Rapraeger (first)
Alison Krufka (additional)
Bradley B. Olwin (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 6:10 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 9:01 a.m.)
Indexed	2 days, 2 hours ago (Aug. 23, 2025, 1:02 a.m.)
Issued	34 years, 2 months ago (June 21, 1991)
Published	34 years, 2 months ago (June 21, 1991)
Published Print	34 years, 2 months ago (June 21, 1991)

Funders 0

None

BibTeX

@article{Rapraeger_1991, title={Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation}, volume={252}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1646484}, DOI={10.1126/science.1646484}, number={5013}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Rapraeger, Alan C. and Krufka, Alison and Olwin, Bradley B.}, year={1991}, month=jun, pages={1705–1708} }

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