DOI: 10.1126/science.163.3870.937. Cytotoxic Effects of Leukocytes Triggered by Complement Bound to Target Cells

Cytotoxic Effects of Leukocytes Triggered by Complement Bound to Target Cells

10.1126/science.163.3870.937

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Chromium-51-labeled chicken erythrocytes (E), treated with rabbit anti-Forssman antibody (A) and the first four (C1-4) or the first seven (C1-7) components of human complement (C), released isotope upon exposure to human leukocytes. Isotope release from EAC1-7 cells proceeded more rapidly and was more extensive than that from EAC1-3 cells. Lysis of these cells was suppressed by pretreatment of leukocytes with antimycin A. Monocyte-enriched leukocyte preparations affected both types of target cell-complement intermediates, whereas purified lymphocytes lysed EAC1-7 cells but not EAC1-3 cells.

Bibliography

Perlmann, P., Perlmann, H., MÃ¼ller-Eberhard, H. J., & Manni, J. A. (1969). Cytotoxic Effects of Leukocytes Triggered by Complement Bound to Target Cells. Science, 163(3870), 937â939.

Authors 4

Peter Perlmann (first)
Hedvig Perlmann (additional)
Hans J. Müller-Eberhard (additional)
Jorge A. Manni (additional)

References 29 Referenced 62

BENNETT, W.E., ISOLATION AND SELECTED PROPERTIES OF BLOOD MONOCYTES, JOURNAL OF EXPERIMENTAL MEDICINE 123: 145 (1966). (10.1084/jem.123.1.145) / JOURNAL OF EXPERIMENTAL MEDICINE (1966)
BRUNNER, K.T., QUANTITATIVE ASSAY OF LYTIC ACTION OF IMMUNE LYMPHOID CELLS ON 51CR-LABELLED ALLOGENEIC TARGET CELLS IN VITRO - INHIBITION BY ISOANTIBODY AND BY DRUGS, IMMUNOLOGY 14: 181 (1968). / IMMUNOLOGY (1968)
COOPER, N.R., A COMPARISON OF METHODS FOR MOLECULAR QUANTITATION OF FOURTH COMPONENT OF HUMAN COMPLEMENT, IMMUNOCHEMISTRY 5: 155 (1968). (10.1016/0019-2791(68)90100-6) / IMMUNOCHEMISTRY (1968)
GORDON, J, ROLE OF MONOCYTES IN MIXED LEUKOCYTE CULTURE REACTION, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 127: 30 (1968). (10.3181/00379727-127-32613) / PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE (1968)
GOVAERTS, A, CELLULAR ANTIBODIES IN KIDNEY HOMOTRANSPLANTATION, JOURNAL OF IMMUNOLOGY 85: 516 (1960). (10.4049/jimmunol.85.5.516) / JOURNAL OF IMMUNOLOGY (1960)
GRANGER, G.A., HOMOGRAFT TARGET CELLS - CONTACT DESTRUCTION IN VITRO BY IMMUNE MACROPHAGES, SCIENCE 151: 97 (1966). (10.1126/science.151.3706.97) / SCIENCE (1966)
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Holm, G., Advances in Transplantation: 155 (1968). / Advances in Transplantation (1968)
HOLM, G, IN VITRO CYTOTOXICITY OF HUMAN LYMPHOCYTES - EFFECT OF METABOLIC INHIBITORS, EXPERIMENTAL CELL RESEARCH 48: 334 (1967). (10.1016/0014-4827(67)90359-X) / EXPERIMENTAL CELL RESEARCH (1967)
HOLM, G, QUANTITATIVE STUDIES ON PHYTOHAEMAGGLUTININ-INDUCED CYTOTOXICITY BY HUMAN LYMPHOCYTES AGAINST HOMOLOGOUS CELLS IN TISSUE CULTURE, IMMUNOLOGY 12: 525 (1967). / IMMUNOLOGY (1967)
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10.1126/science.160.3825.306
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RABINOWITZ, Y, SEPARATION OF LYMPHOCYTES POLYMORPHONUCLEAR LEUKOCYTES + MONOCYTES ON GLASS COLUMNS INCLUDING TISSUE CULTURE OBSERVATIONS, BLOOD 23: 811 (1964). (10.1182/blood.V23.6.811.811) / BLOOD (1964)
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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 8:14 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 3:48 a.m.)
Indexed	4 months, 3 weeks ago (April 10, 2025, 6:30 a.m.)
Issued	56 years, 6 months ago (Feb. 28, 1969)
Published	56 years, 6 months ago (Feb. 28, 1969)
Published Print	56 years, 6 months ago (Feb. 28, 1969)

Funders 0

None

BibTeX

@article{Perlmann_1969, title={Cytotoxic Effects of Leukocytes Triggered by Complement Bound to Target Cells}, volume={163}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.163.3870.937}, DOI={10.1126/science.163.3870.937}, number={3870}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Perlmann, Peter and Perlmann, Hedvig and Müller-Eberhard, Hans J. and Manni, Jorge A.}, year={1969}, month=feb, pages={937–939} }

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