DOI: 10.1126/science.1621094. Neurexins: Synaptic Cell Surface Proteins Related to the α-Latrotoxin Receptor and Laminin

Neurexins: Synaptic Cell Surface Proteins Related to the α-Latrotoxin Receptor and Laminin

10.1126/science.1621094

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

A family of highly polymorphic neuronal cell surface proteins, the neurexins, has been identified. At least two genes for neurexins exist. Each gene uses alternative promoters and multiple variably spliced exons to potentially generate more than a 100 different neurexin transcripts. The neurexins were discovered by the identification of one member of the family as the receptor for α-latrotoxin. This toxin is a component of the venom from black widow spiders; it binds to presynaptic nerve terminals and triggers massive neurotransmitter release. Neurexins contain single transmembrane regions and extracellular domains with repeated sequences similar to sequences in laminin A, slit, and agrin, proteins that have been implicated in axon guidance and synaptogenesis. An antibody to neurexin I showed highly concentrated immunoreactivity at the synapse. The polymorphic structure of the neurexins, their neural localization, and their sequence similarity to proteins associated with neurogenesis suggest a function as cell recognition molecules in the nerve terminal.

Bibliography

Ushkaryov, Y. A., Petrenko, A. G., Geppert, M., & SÃ¼dhof, T. C. (1992). Neurexins: Synaptic Cell Surface Proteins Related to the Î±-Latrotoxin Receptor and Laminin. Science, 257(5066), 50â56.

Authors 4

Yuri A. Ushkaryov (first)
Alexander G. Petrenko (additional)
Martin Geppert (additional)
Thomas C. Südhof (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:03 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 4:02 a.m.)
Indexed	2 weeks, 5 days ago (Aug. 7, 2025, 4:55 a.m.)
Issued	33 years, 1 month ago (July 3, 1992)
Published	33 years, 1 month ago (July 3, 1992)
Published Print	33 years, 1 month ago (July 3, 1992)

Funders 0

None

BibTeX

@article{Ushkaryov_1992, title={Neurexins: Synaptic Cell Surface Proteins Related to the α-Latrotoxin Receptor and Laminin}, volume={257}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1621094}, DOI={10.1126/science.1621094}, number={5066}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Ushkaryov, Yuri A. and Petrenko, Alexander G. and Geppert, Martin and Südhof, Thomas C.}, year={1992}, month=jul, pages={50–56} }

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