DOI: 10.1126/science.162.3861.1495. Sterol Precursors of Cholesterol in Adult Human Brain

Sterol Precursors of Cholesterol in Adult Human Brain

10.1126/science.162.3861.1495

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Adult human brain contains cholestanol and two series of cholesterol precursors having 30, 29, 28, and 27 carbon atoms; one has an unsaturated steroid nucleus, and the other is unsaturated in both nucleus and side chain. The ability of preparations of brain to incorporate a specific precursor into cholesterol, as well as into these sterol metabolites in vitro, indicates that cholesterol synthesis continues long after brain maturation ceases.

Bibliography

Galli, G., Paoletti, E. G., & Weiss, J. F. (1968). Sterol Precursors of Cholesterol in Adult Human Brain. Science, 162(3861), 1495â1496.

Authors 3

Giovanni Galli (first)
Enrica Grossi Paoletti (additional)
Joseph F. Weiss (additional)

References 19 Referenced 12

DAVISON, A.N., ADV LIPID RES 3: 171 (1965). (10.1016/B978-1-4831-9939-9.50011-5) / ADV LIPID RES (1965)
FIESER, L.F., CHOLESTEROL AND COMPANIONS .6. LATHOSTEROL, CHOLESTANETRIOL AND KETONE 104 FROM A VARIETY OF SOURCES, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 75: 4418 (1953). (10.1021/ja01114a006) / JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (1953)
FIESER, L.F., J ORG CHEM 22: 1380 (1957). (10.1021/jo01362a021) / J ORG CHEM (1957)
FISH, W.A., METABOLISM OF CHOLESTEROL IN CHICK EMBRYO .3. LOCALIZATION AND TURNOVER OF DESMOSTEROL (24-DEHYDROCHOLESTEROL), JOURNAL OF BIOLOGICAL CHEMISTRY 237: 334 (1962). (10.1016/S0021-9258(18)93924-4) / JOURNAL OF BIOLOGICAL CHEMISTRY (1962)
Fumagalli R. Annals of the New York Academy of Sciences in press.
GALLI, G, SEPARATION OF CHOLESTEROL-DESMOSTEROL ACETATES BY THIN-LAYER AND COLUMN CHROMATOGRAPHY ON SILICA GEL G-SILVER NITRATE, LIPIDS 2: 72 (1967). (10.1007/BF02532004) / LIPIDS (1967)
GALLI, G, QUANTITATIVE SEPARATION OF C-27 STEROL PRECURSORS OF CHOLESTEROL, LIPIDS 2: 84 (1967). (10.1007/BF02532007) / LIPIDS (1967)
GALLI, G, MASS SPECTROMETRIC INVESTIGATIONS OF SOME UNSATURATED STEROLS BIOSYNTHETICALLY RELATED TO CHOLESTEROL, STEROIDS 10: 189 (1967). (10.1016/0039-128X(67)90046-3) / STEROIDS (1967)
GROSSI, E, AN ANALYSIS OF BRAIN CHOLESTEROL AND FATTY ACID BIOSYNTHESIS, ARCHIVES INTERNATIONALES DE PHYSIOLOGIE ET DE BIOCHIMIE 66: 564 (1958). (10.3109/13813455809084233) / ARCHIVES INTERNATIONALES DE PHYSIOLOGIE ET DE BIOCHIMIE (1958)
KABARA, J.J., BRAIN CHOLESTEROL .11. A REVIEW OF BIOSYNTHESIS IN ADULT MICE, JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY 42: 1003 (1965). (10.1007/BF02636892) / JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY (1965)
KOCH, E.M., Provitamin D potency of some sterol derivatives, JOURNAL OF BIOLOGICAL CHEMISTRY 116: 757 (1936). (10.1016/S0021-9258(18)74648-6) / JOURNAL OF BIOLOGICAL CHEMISTRY (1936)
KRITCHEVSKY, D, DESMOSTEROL IN DEVELOPING RAT BRAIN, JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY 42: 1024 (1965). (10.1007/BF02636896) / JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY (1965)
NAKANISHI, K, CHOLESTEROL AND COMPANIONS .5. MICRODETERMINATION OF DELTA-7-STENOLS, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 75: 4415 (1953). (10.1021/ja01114a005) / JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (1953)
OLSON, J.A., ERGEBNISSE DER PHYSIOLOGIE 56: 173 (1965). (10.1007/BF02270551) / ERGEBNISSE DER PHYSIOLOGIE (1965)
PAGE, I.H., The appearance of eigersterine in the human brain, BIOCHEMISCHE ZEITSCHRIFT 231: 446 (1931). / BIOCHEMISCHE ZEITSCHRIFT (1931)
PAGE, I.H., HOPPE-SEYLER'S ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 204: 13 (1932). (10.1515/bchm2.1932.204.1-2.13) / HOPPE-SEYLER'S ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE (1932)
PAOLETTI, R, STUDIES ON BRAIN STEROLS IN NORMAL AND PATHOLOGICAL CONDITIONS, JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY 42: 400 (1965). (10.1007/BF02635575) / JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY (1965)
SCHOENHEIMER, R, HOPPE-SEYLER'S ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 192: 93 (1930). / HOPPE-SEYLER'S ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE (1930)
WEISS, J.F., STEROLS WITH 29 28 AND 27 CARBON ATOMS METABOLICALLY RELATED TO CHOLESTEROL OCCURRING IN DEVELOPING AND MATURE BRAIN, JOURNAL OF NEUROCHEMISTRY 15: 563 (1968). (10.1111/j.1471-4159.1968.tb08955.x) / JOURNAL OF NEUROCHEMISTRY (1968)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:50 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 4:41 a.m.)
Indexed	1 year, 7 months ago (Jan. 11, 2024, 7:03 p.m.)
Issued	56 years, 8 months ago (Dec. 27, 1968)
Published	56 years, 8 months ago (Dec. 27, 1968)
Published Print	56 years, 8 months ago (Dec. 27, 1968)

Funders 0

None

BibTeX

@article{Galli_1968, title={Sterol Precursors of Cholesterol in Adult Human Brain}, volume={162}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.162.3861.1495}, DOI={10.1126/science.162.3861.1495}, number={3861}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Galli, Giovanni and Paoletti, Enrica Grossi and Weiss, Joseph F.}, year={1968}, month=dec, pages={1495–1496} }

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