DOI: 10.1126/science.162.3861.1484. Inhibition of Cell Growth in vitro by Adenosine 3′,5′-Monophosphate

Inhibition of Cell Growth in vitro by Adenosine 3′,5′-Monophosphate

10.1126/science.162.3861.1484

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Adenosine 3′,5′-monophosphate, at a concentration of 40 micrograms per milliliter, inhibits the growth of HeLa and strain L cells in culture. The inhibition becomes progressively greater during the incubation of the cells. Adenosine 5′-monophosphate and adenosine, metabolites of adenosine 3′,5′-monophosphate, do not affect the growth of either cell culture. This suggests that adenosine 3′,5′-monophosphate enters the cell without alteration. Dibutyryl-adenosine 3′,5′-monophosphate, reported to have a greater activity than adenosine 3′5′-monophosphate on several tissues, inhibited the growth of the cells much less.

Bibliography

Ryan, W. L., & Heidrick, M. L. (1968). Inhibition of Cell Growth in vitro by Adenosine 3â²,5â²-Monophosphate. Science, 162(3861), 1484â1485.

Authors 2

Wayne L. Ryan (first)
Margaret L. Heidrick (additional)

References 15 Referenced 184

ARPELS, C, EFFECT OF STEROIDS ON HUMAN CELL CULTURES - SUSTAINING EFFECT OF HYDROCORTISONE, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 115: 102 (1964). (10.3181/00379727-115-28842) / PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE (1964)
BDOLAH, A, FUNCTION OF 3'5' CYCLIC AMP IN ENZYME SECRETION, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 18: 452 (1965). (10.1016/0006-291X(65)90730-8) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1965)
BUTCHER, R.W., ADENOSINE 3',5'-MONOPHOSPHATE IN BIOLOGICAL MATERIALS .2. MEASUREMENT OF ADENOSINE 3',5'-MONOPHOSPHATE IN TISSUES AND ROLE OF CYCLIC NUCLEOTIDE IN LIPOLYTIC RESPONSE OF FAT TO EPINEPHRINE, JOURNAL OF BIOLOGICAL CHEMISTRY 240: 4515 (1965). (10.1016/S0021-9258(18)97092-4) / JOURNAL OF BIOLOGICAL CHEMISTRY (1965)
10.1126/science.122.3168.501
GROSSFIELD, H, ACTION OF ADRENALCORTICAL STEROIDS ON CULTURED CELLS, ENDOCRINOLOGY 65: 777 (1959). (10.1210/endo-65-5-777) / ENDOCRINOLOGY (1959)
HECHTER, O, ESTROGEN-LIKE ANABOLIC EFFECTS OF CYCLIC 3',5' ADENOSINE MONOPHOSPHATE AND OTHER NUCLEOTIDES IN ISOLATED RAT UTERUS, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 122: 449 (1967). (10.1016/0003-9861(67)90219-6) / ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (1967)
KLINE, I, SOME OBSERVATIONS ON THE RESPONSE OF 4 ESTABLISHED HUMAN CELL STRAINS TO HYDROCORTISONE IN TISSUE CULTURE, CANCER RESEARCH 17: 780 (1957). / CANCER RESEARCH (1957)
Lasnitzki, I., Cells and Tissues in Culture 1: 591 (1965). / Cells and Tissues in Culture (1965)
LEIBMAN, K.C., THE METABOLISM OF P-32-LABELED RIBONUCLEOTIDES IN TISSUE SLICES AND CELL SUSPENSIONS, JOURNAL OF BIOLOGICAL CHEMISTRY 216: 823 (1955). (10.1016/S0021-9258(19)81436-9) / JOURNAL OF BIOLOGICAL CHEMISTRY (1955)
MOORE, P. F., JOURNAL OF PHARMACY AND PHARMACOLOGY 20: 368 (1968). (10.1111/j.2042-7158.1968.tb09761.x) / JOURNAL OF PHARMACY AND PHARMACOLOGY (1968)
Paul J. Cell and Tissue Culture 3 86 (1965).
POSTERNAK, T, DERIVATIVES OF CYCLIC 3',5'-ADENOSINE MONOPHOSPHATE, BIOCHIMICA ET BIOPHYSICA ACTA 65: 558 (1962). (10.1016/0006-3002(62)90475-4) / BIOCHIMICA ET BIOPHYSICA ACTA (1962)
ROLL, P.M., UTILIZATION OF NUCLEOTIDES BY THE MAMMAL .4. TRIPLY LABELED PURINE NUCLEOTIDES, JOURNAL OF BIOLOGICAL CHEMISTRY 220: 439 (1956). (10.1016/S0021-9258(18)65368-2) / JOURNAL OF BIOLOGICAL CHEMISTRY (1956)
SUTHERLAND, E.W., SOME ASPECTS OF BIOLOGICAL ROLE OF ADENOSINE 3',5'-MONOPHOSPHATE (CYCLIC AMP), CIRCULATION 37: 279 (1968). (10.1161/01.CIR.37.2.279) / CIRCULATION (1968)
WAYMOUTH, C, RAPID PROLIFERATION OF SUBLINES OF NCTC CLONE 929 (STRAIN-L) MOUSE CELLS IN A SIMPLE CHEMICALLY DEFINED MEDIUM (MB-752-1), JOURNAL OF THE NATIONAL CANCER INSTITUTE 22: 1003 (1959). (10.1093/jnci/22.5.1003) / JOURNAL OF THE NATIONAL CANCER INSTITUTE (1959)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:50 a.m.)
Deposited	7 months, 2 weeks ago (Jan. 11, 2025, 12:15 a.m.)
Indexed	7 months, 2 weeks ago (Jan. 11, 2025, 12:40 a.m.)
Issued	56 years, 8 months ago (Dec. 27, 1968)
Published	56 years, 8 months ago (Dec. 27, 1968)
Published Print	56 years, 8 months ago (Dec. 27, 1968)

Funders 0

None

BibTeX

@article{Ryan_1968, title={Inhibition of Cell Growth in vitro by Adenosine 3′,5′-Monophosphate}, volume={162}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.162.3861.1484}, DOI={10.1126/science.162.3861.1484}, number={3861}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Ryan, Wayne L. and Heidrick, Margaret L.}, year={1968}, month=dec, pages={1484–1485} }

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