DOI: 10.1126/science.162.3857.1018. Tyrosine Aminotransferase: Enzyme Induction Independent of Adenosine 3′,5′-Monophosphate

Tyrosine Aminotransferase: Enzyme Induction Independent of Adenosine 3′,5′-Monophosphate

10.1126/science.162.3857.1018

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The importance of adenyl cyclase and adenosine 3′,5′-monophosphate in the induction of tyrosine aminotransferase by adrenocorticosteroids has been tested in HTC cells derived from a rat hepatoma and grown in tissue culture. Adrenocorticosteroids cause a 10- to 15-fold increase in the rate of synthesis of tyrosine aminotransferase in these cells. Under various experimental conditions, with or without glucocorticoids, neither adenyl cyclase nor cyclic adenosine monophosphate could be detected in HTC cells. In addition, neither the cyclic nucleotide nor N 6 , O 2 ′-dibutyryl cyclic adenosine monophosphate caused increased activity of the transaminase in HTC cells. We conclude that induction of tyrosine aminotransferase by glucocorticoids is not mediated by the adenyl cyclase-cyclic adenosine monophosphate system.

Bibliography

Granner, D., Chase, L. R., Aurbach, G. D., & Tomkins, G. M. (1968). Tyrosine Aminotransferase: Enzyme Induction Independent of Adenosine 3â²,5â²-Monophosphate. Science, 162(3857), 1018â1020.

Authors 4

D. Granner (first)
L. R. Chase (additional)
G. D. Aurbach (additional)
G. M. Tomkins (additional)

References 18 Referenced 103

Aurbach, G. D., Journal of Biological Chemistry 243: 5935 (1968). (10.1016/S0021-9258(18)94510-2) / Journal of Biological Chemistry (1968)
BARNABEI, O, BOLLETTINO DELLA SOCIETA ITALIANO DI BIOLOGIA SPERIMENTALE 36: 1656 (1960). / BOLLETTINO DELLA SOCIETA ITALIANO DI BIOLOGIA SPERIMENTALE (1960)
CHASE, L.R., PARATHYROID FUNCTION AND RENAL EXCRETION OF 3'5'-ADENYLIC ACID, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 58: 518 (1967). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1967)
10.1126/science.159.3814.545
DIAMONDSTONE, T.I., ASSAY OF TYROSINE TRANSAMINASE ACTIVITY BY CONVERSION OF P-HYDROXYPHENYLPYRUVATE TO P-HYDROXYBENZALDEHYDE, ANALYTICAL BIOCHEMISTRY 16: 395 (1966). (10.1016/0003-2697(66)90220-X) / ANALYTICAL BIOCHEMISTRY (1966)
GOLDSTEIN, L, EFFECT OF HYDROCORTISONE ON TYROSINE-ALPHA-KETOGLUTARATE TRANSAMINASE AND TRYPTOPHAN PYRROLASE ACTIVITIES IN ISOLATED, PERFUSED RAT LIVER, JOURNAL OF BIOLOGICAL CHEMISTRY 237: 1723 (1962). (10.1016/S0021-9258(19)83768-7) / JOURNAL OF BIOLOGICAL CHEMISTRY (1962)
GRANNER, D.K., STIMULATION OF TYROSINE AMINOTRANSFERASE SYNTHESIS BY DEXAMETHASONE PHOSPHATE IN CELL CULTURE, JOURNAL OF MOLECULAR BIOLOGY 35: 291 (1968). (10.1016/S0022-2836(68)80025-7) / JOURNAL OF MOLECULAR BIOLOGY (1968)
GREENGARD, O, INITIATION BY GLUCAGON OF PREMATURE DEVELOPMENT OF TYROSINE AMINOTRANSFERASE SERINE DEYHDRATASE AND GLUCOSE-6-PHOSPHATASE IN FETAL RAT LIVER, JOURNAL OF BIOLOGICAL CHEMISTRY 242: 2986 (1967). (10.1016/S0021-9258(18)99602-X) / JOURNAL OF BIOLOGICAL CHEMISTRY (1967)
HAGER, C.B., J BIOL CHEM 243: 3301 (1968). (10.1016/S0021-9258(18)93307-7) / J BIOL CHEM (1968)
HOLTEN, D, REGULATION OF TYROSINE ALPHA-KETOGLUTARATE TRANSAMINASE IN RAT LIVER .6. INDUCTION BY PANCREATIC HORMONES, JOURNAL OF BIOLOGICAL CHEMISTRY 242: 4372 (1967). (10.1016/S0021-9258(18)99548-7) / JOURNAL OF BIOLOGICAL CHEMISTRY (1967)
KENNEY, F.T., INDUCTION OF TYROSINE-ALPHA-KETOGLUTARATE TRANSAMINASE IN RAT LIVER .4. EVIDENCE FOR AN INCREASE IN RATE OF ENZYME SYNTHESIS, JOURNAL OF BIOLOGICAL CHEMISTRY 237: 3495 (1962). (10.1016/S0021-9258(19)70845-X) / JOURNAL OF BIOLOGICAL CHEMISTRY (1962)
PASTAN, I, EFFECT OF DIBUTYRYL CYCLIC 3',5'-AMP ON THYROID, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 25: 14 (1966). (10.1016/0006-291X(66)90632-2) / BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (1966)
SHARP, G. W. G., JOURNAL OF CLINICAL INVESTIGATION 47: A89 (1968). / JOURNAL OF CLINICAL INVESTIGATION (1968)
SUTHERLAND, E.W., SOME ASPECTS OF BIOLOGICAL ROLE OF ADENOSINE 3',5'-MONOPHOSPHATE (CYCLIC AMP), CIRCULATION 37: 279 (1968). (10.1161/01.CIR.37.2.279) / CIRCULATION (1968)
SZEGO, C.M., ADENOSINE 3',5'-MONOPHOSPHATE IN RAT UTERUS - ACUTE ELEVATION BY ESTROGEN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 58: 1711 (1967). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1967)
THOMPSON, E.B., INDUCTION OF TYROSINE ALPHA-KETOGLUTARATE TRANSAMINASE BY STEROID HORMONES IN A NEWLY ESTABLISHED TISSUE CULTURE CELL LINE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 56: 296 (1966). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1966)
WICKS, W.D., INDUCTION OF TYROSINE-ALPHA-KETOGLUTARATE TRANSAMINASE IN FETAL RAT LIVER, JOURNAL OF BIOLOGICAL CHEMISTRY 243: 900 (1968). (10.1016/S0021-9258(18)93601-X) / JOURNAL OF BIOLOGICAL CHEMISTRY (1968)
10.1126/science.160.3831.997

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:50 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 4:34 a.m.)
Indexed	12 hours, 19 minutes ago (Sept. 4, 2025, 10:23 a.m.)
Issued	56 years, 9 months ago (Nov. 29, 1968)
Published	56 years, 9 months ago (Nov. 29, 1968)
Published Print	56 years, 9 months ago (Nov. 29, 1968)

Funders 0

None

BibTeX

@article{Granner_1968, title={Tyrosine Aminotransferase: Enzyme Induction Independent of Adenosine 3′,5′-Monophosphate}, volume={162}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.162.3857.1018}, DOI={10.1126/science.162.3857.1018}, number={3857}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Granner, D. and Chase, L. R. and Aurbach, G. D. and Tomkins, G. M.}, year={1968}, month=nov, pages={1018–1020} }

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