DOI: 10.1126/science.158.3808.1582. Red Cells Coated with Immunoglobulin G: Binding and Sphering by Mononuclear Cells in Man

Red Cells Coated with Immunoglobulin G: Binding and Sphering by Mononuclear Cells in Man

10.1126/science.158.3808.1582

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Human monocytes, macrophages, and certain lymphocytes bind firmly to red cells coated with immunoglobulin G, whether or not it is acting as antibody. Monocyte binding is specific for cells coated with immunoglobulin G and is inhibited specifically by this immunoglobulin or its Fc-fragment in solution. Although not involving serum complement and not usually a prelude to erythrophagocytosis, this binding causes rapid morphological injury to red cells, as manifested by their sphering, increased osmotic fragility, deformation, and fragmentation. It is inferred that mononuclear cells have specific surface receptors for immunoglobulin G and that these provide a critical phase of the mechanism in vivo, whereby red cells or other particles coated with antibody are apprehended and destroyed.

Bibliography

LoBuglio, A. F., Cotran, R. S., & Jandl, J. H. (1967). Red Cells Coated with Immunoglobulin G: Binding and Sphering by Mononuclear Cells in Man. Science, 158(3808), 1582â1585.

Authors 3

Albert F. LoBuglio (first)
Ramzi S. Cotran (additional)
James H. Jandl (additional)

References 20 Referenced 303

ALPERT, C.A., METABOLISM OF GAMMA GLOBULINS IN MYELOMA AND ALLIED CONDITIONS, JOURNAL OF CLINICAL INVESTIGATION 42: 1858 (1963). (10.1172/JCI104870) / JOURNAL OF CLINICAL INVESTIGATION (1963)
ARCHER, G.T., PHAGOCYTOSIS BY HUMAN MONOCYTES OF RED CELLS COATED WITH RH ANTIBODIES, VOX SANGUINIS 10: 590 (1965). (10.1111/j.1423-0410.1965.tb01413.x) / VOX SANGUINIS (1965)
BERKEN, A, PROPERTIES OF ANTIBODIES CYTOPHILIC FOR MACROPHAGES, JOURNAL OF EXPERIMENTAL MEDICINE 123: 119 (1966). (10.1084/jem.123.1.119) / JOURNAL OF EXPERIMENTAL MEDICINE (1966)
BOYDEN, S.V., CYTOPHILIC ANTIBODY IN GUINEA-PIGS WITH DELAYED-TYPE HYPERSENSITIVITY, IMMUNOLOGY 7: 474 (1964). / IMMUNOLOGY (1964)
COOPER, M.B., ERYTHROPHAGOCYTOSIS IN HEMOLYTIC DISEASE OF THE NEWBORN - A REPORT OF 25 CASES, BLOOD 5: 678 (1950). (10.1182/blood.V5.7.678.678) / BLOOD (1950)
EDELMAN, G.M., IMMUNOLOGICAL STUDIES OF HUMAN GAMMA-GLOBULIN - RELATION OF THE PRECIPITIN LINES OF WHOLE GAMMA-GLOBULIN TO THOSE OF THE FRAGMENTS PRODUCED BY PAPAIN, JOURNAL OF EXPERIMENTAL MEDICINE 112: 203 (1960). (10.1084/jem.112.1.203) / JOURNAL OF EXPERIMENTAL MEDICINE (1960)
FLODIN, P, FRACTIONATION OF HUMAN-SERUM PROTEINS BY GEL FILTRATION, BIOCHIMICA ET BIOPHYSICA ACTA 63: 403 (1962). (10.1016/0006-3002(62)90104-X) / BIOCHIMICA ET BIOPHYSICA ACTA (1962)
HAM, T.H., STUDIES ON THE DESTRUCTION OF RED BLOOD CELLS .4., BLOOD 3: 373 (1948). (10.1182/blood.V3.4.373.373) / BLOOD (1948)
JANDL, J.H., THE AGGLUTINATION AND SENSITIZATION OF RED CELLS BY METALLIC CATIONS - INTERACTIONS BETWEEN MULTIVALENT METALS AND THE RED-CELL MEMBRANE, BRITISH JOURNAL OF HAEMATOLOGY 3: 19 (1957). (10.1111/j.1365-2141.1957.tb05768.x) / BRITISH JOURNAL OF HAEMATOLOGY (1957)
JANDL, J.H., THE DESTRUCTION OF RED CELLS BY ANTIBODIES IN MAN .1. OBSERVATIONS ON THE SEQUESTRATION AND LYSIS OF RED CELLS ALTERED BY IMMUNE MECHANISMS, JOURNAL OF CLINICAL INVESTIGATION 36: 1428 (1957). (10.1172/JCI103542) / JOURNAL OF CLINICAL INVESTIGATION (1957)
JANDL, J.H., DESTRUCTION OF RED CELLS BY ANTIBODIES IN MAN .2. PYROGENIC, LEUKOCYTIC AND DERMAL RESPONSES TO IMMUNE HEMOLYSIS, JOURNAL OF CLINICAL INVESTIGATION 37: 1202 (1958). (10.1172/JCI103710) / JOURNAL OF CLINICAL INVESTIGATION (1958)
KAPLAN, M.E., EFFECT OF RHEUMATOID FACTORS AND OF ANTIGLOBULINS ON IMMUNE HEMOLYSIS IN VIVO, JOURNAL OF EXPERIMENTAL MEDICINE 117: 105 (1963). (10.1084/jem.117.1.105) / JOURNAL OF EXPERIMENTAL MEDICINE (1963)
LOBUGLIO, A.F., SPECIFIC BINDING AND SPHERING OF GAMMAG-GLOBULIN-COATED RED CELLS BY HUMAN MONOCYTES AND SPLENIC MACROPHAGES, JOURNAL OF CLINICAL INVESTIGATION 46: 1087 (1967). / JOURNAL OF CLINICAL INVESTIGATION (1967)
LOBUGLIO, A.F., NATURE OF ALPHA-METHYLDOPA RED-CELL ANTIBODY, NEW ENGLAND JOURNAL OF MEDICINE 276: 658 (1967). (10.1056/NEJM196703232761203) / NEW ENGLAND JOURNAL OF MEDICINE (1967)
MOLLISON, P.L., UPTAKE OF GAMMA-GLOBULIN + COMPLEMENT BY RED CELLS EXPOSED TO SERUM AT LOW IONIC STRENGTH, NATURE 203: 535 (1964). (10.1038/203535a0) / NATURE (1964)
RABINOVITCH, M, DISSOCIATION OF ATTACHMENT AND INGESTION PHASES OF PHAGOCYTOSIS BY MACROPHAGES, EXPERIMENTAL CELL RESEARCH 46: 19 (1967). (10.1016/0014-4827(67)90405-3) / EXPERIMENTAL CELL RESEARCH (1967)
SENNOTT, J.S., ERYTHROPHAGOCYTOSIS IN ACUTE HEMOLYTIC ANEMIA OF THE NEWBORN - A REPORT OF 3 CASES, AMERICAN JOURNAL OF DISEASES OF CHILDREN 71: 269 (1946). (10.1001/archpedi.1946.02020260062005) / AMERICAN JOURNAL OF DISEASES OF CHILDREN (1946)
SOUTHAM, C.M., A QUANTITATIVE REBUCK TECHNIC, BLOOD-THE JOURNAL OF HEMATOLOGY 27: 734 (1966). / BLOOD-THE JOURNAL OF HEMATOLOGY (1966)
TOMASI, T.B., CHARACTERISTICS OF AN IMMUNE SYSTEM COMMON TO CERTAIN EXTERNAL SECRETIONS, JOURNAL OF EXPERIMENTAL MEDICINE 121: 101 (1965). (10.1084/jem.121.1.101) / JOURNAL OF EXPERIMENTAL MEDICINE (1965)
WEED, R.I., MEMBRANE ALTERATIONS LEADING TO RED CELL DESTRUCTION, AMERICAN JOURNAL OF MEDICINE 41: 681 (1966). (10.1016/0002-9343(66)90030-1) / AMERICAN JOURNAL OF MEDICINE (1966)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:08 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 3:24 a.m.)
Indexed	3 months ago (May 24, 2025, 3:26 a.m.)
Issued	57 years, 8 months ago (Dec. 22, 1967)
Published	57 years, 8 months ago (Dec. 22, 1967)
Published Print	57 years, 8 months ago (Dec. 22, 1967)

Funders 0

None

BibTeX

@article{LoBuglio_1967, title={Red Cells Coated with Immunoglobulin G: Binding and Sphering by Mononuclear Cells in Man}, volume={158}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.158.3808.1582}, DOI={10.1126/science.158.3808.1582}, number={3808}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={LoBuglio, Albert F. and Cotran, Ramzi S. and Jandl, James H.}, year={1967}, month=dec, pages={1582–1585} }

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