DOI: 10.1126/science.158.3800.494. Polycystic Renal Disease: A New Experimental Model

Polycystic Renal Disease: A New Experimental Model

10.1126/science.158.3800.494

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

A single injection of any one of several long-acting adrenal corticosteroids at birth induces progressive cystic changes in nephrons which develop in the subcapsular zone of the rabbit kidney until 10 days after birth. These cystic lesions enlarge progressively and become visible within a few days after birth. When the animal is 2 weeks old, renal size has become three times as large as that of uninjected littermates. Adrenal corticosteroids prolong the duration of nephrogenic activity in the renal cortex. The cysts are blind and represent dilatation of the developing end of the collecting ducts. When the steroid-induced hypokalemia is prevented with repeated potassium chloride injections, renal cystic disease is almost completely prevented. Certain long-acting steroids induce cystic renal changes without systemic signs of toxicity.

Bibliography

Perey, D. Y. E., Herdman, R. C., & Good, R. A. (1967). Polycystic Renal Disease: A New Experimental Model. Science, 158(3800), 494â496.

Authors 3

Daniel Y. E. Perey (first)
Roger C. Herdman (additional)
Robert A. Good (additional)

References 14 Referenced 59

BAXTER, T.J., CORTISONE-INDUCED RENAL CHANGES IN THE RABBIT - A MICRODISSECTION STUDY, BRITISH JOURNAL OF EXPERIMENTAL PATHOLOGY 41: 140 (1960). / BRITISH JOURNAL OF EXPERIMENTAL PATHOLOGY (1960)
DARMADY, E.M., MICRODISSECTION OF THE NEPHRON IN DISEASE, BRITISH MEDICAL BULLETIN 13: 21 (1957). (10.1093/oxfordjournals.bmb.a069564) / BRITISH MEDICAL BULLETIN (1957)
DEANE, H.W., THE EFFECT OF ALTERED SODIUM OR POTASSIUM INTAKE ON THE WIDTH AND CYTOCHEMISTRY OF THE ZONA GLOMERULOSA OF THE RATS ADRENAL CORTEX, ENDOCRINOLOGY 43: 133 (1948). (10.1210/endo-43-3-133) / ENDOCRINOLOGY (1948)
FOLLIS, R.H., AM J PATHOL 18: 29 (1942). / AM J PATHOL (1942)
KIME, S.W., EXPERIMENTAL POLYCYSTIC RENAL DISEASE IN RATS - ELECTRON MICROSCOPY, FUNCTION, AND SUSCEPTIBILITY TO PYELONEPHRITIS, JOURNAL OF LABORATORY AND CLINICAL MEDICINE 60: 64 (1962). / JOURNAL OF LABORATORY AND CLINICAL MEDICINE (1962)
KORNBERG, A, POTASSIUM DEFICIENCY IN THE RAT, AMERICAN JOURNAL OF PHYSIOLOGY 145: 291 (1946). (10.1152/ajplegacy.1946.145.3.291) / AMERICAN JOURNAL OF PHYSIOLOGY (1946)
MEYER, J.H., EFFECT OF DIETARY LEVELS OF SODIUM AND POTASSIUM ON GROWTH AND ON CONCENTRATIONS IN BLOOD PLASMA AND TISSUES OF WHITE RAT, AMERICAN JOURNAL OF PHYSIOLOGY 162: 182 (1950). (10.1152/ajplegacy.1950.162.1.182) / AMERICAN JOURNAL OF PHYSIOLOGY (1950)
NEWBERNE, P.M., CARDIORENAL LESIONS OF POTASSIUM DEPLETION OR STEROID THERAPY IN RAT, AMERICAN JOURNAL OF VETERINARY RESEARCH 25: 1256 (1964). / AMERICAN JOURNAL OF VETERINARY RESEARCH (1964)
OLIVER, J, THE RENAL LESIONS OF ELECTROLYTE IMBALANCE .1. THE STRUCTURAL ALTERATIONS IN POTASSIUM-DEPLETED RATS, JOURNAL OF EXPERIMENTAL MEDICINE 106: 563 (1957). (10.1084/jem.106.4.563) / JOURNAL OF EXPERIMENTAL MEDICINE (1957)
OSATHANONDH, V, PATHOGENESIS OF POLYCYSTIC KIDNEYS - TYPE 2 DUE TO INHIBITION OF AMPULLARY ACTIVITY, ARCHIVES OF PATHOLOGY 77: 474 (1964). / ARCHIVES OF PATHOLOGY (1964)
SCHARDER, G.A., J NUTR 14: 85 (1937). (10.1093/jn/14.1.85) / J NUTR (1937)
SPARGO, B, ZONAL RENAL PAPILLARY DROPLET CHANGE WITH POTASSIUM DEPLETION, ARCHIVES OF PATHOLOGY 70: 599 (1960). / ARCHIVES OF PATHOLOGY (1960)
SPARGO, B, KIDNEY CHANGES IN HYPOKALEMIC ALKALOSIS IN THE RAT, JOURNAL OF LABORATORY AND CLINICAL MEDICINE 43: 802 (1954). / JOURNAL OF LABORATORY AND CLINICAL MEDICINE (1954)
THOMAS, J.O., STANFORD MEDICAL BULLETIN 15: 90 (1957). / STANFORD MEDICAL BULLETIN (1957)

Dates

Type	When
Created	18 years, 11 months ago (Oct. 5, 2006, 7:08 a.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 4:36 a.m.)
Indexed	1 year ago (Sept. 4, 2024, 7:47 p.m.)
Issued	57 years, 10 months ago (Oct. 27, 1967)
Published	57 years, 10 months ago (Oct. 27, 1967)
Published Print	57 years, 10 months ago (Oct. 27, 1967)

Funders 0

None

BibTeX

@article{Perey_1967, title={Polycystic Renal Disease: A New Experimental Model}, volume={158}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.158.3800.494}, DOI={10.1126/science.158.3800.494}, number={3800}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Perey, Daniel Y. E. and Herdman, Roger C. and Good, Robert A.}, year={1967}, month=oct, pages={494–496} }

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