DOI: 10.1126/science.1532456. Activation of T Cells by a Tyrosine Kinase Activation Domain in the Cytoplasmic Tail of CD3 ε

Activation of T Cells by a Tyrosine Kinase Activation Domain in the Cytoplasmic Tail of CD3 ε

10.1126/science.1532456

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

The multichain T cell antigen receptor functions by interacting with and activating one or more nonreceptor tyrosine kinases. The cytoplasmic tail of the ζ chain can activate T cells independently of the rest of the receptor complex. The function of the remaining invariant CD3 chains remains unknown. A 22-amino acid region of the cytoplasmic tail of CD3 ε was also able to independently activate T cells. Stimulation of T cells by means of the cytoplasmic tails of either ζ or CD3 ε resulted in quantitatively distinct patterns of tyrosine phosphorylation, suggesting activation of different biochemical pathways.

Bibliography

Letourneur, F., & Klausner, R. D. (1992). Activation of T Cells by a Tyrosine Kinase Activation Domain in the Cytoplasmic Tail of CD3 Îµ. Science, 255(5040), 79â82.

Authors 2

François Letourneur (first)
Richard D. Klausner (additional)

References 23 Referenced 309

ASHWELL, J.D., CELL-GROWTH CYCLE BLOCK OF T-CELL HYBRIDOMAS UPON ACTIVATION WITH ANTIGEN, JOURNAL OF EXPERIMENTAL MEDICINE 165: 173 (1987). (10.1084/jem.165.1.173) / JOURNAL OF EXPERIMENTAL MEDICINE (1987)
10.1126/science.2371564
GUNTER, K.C., T-CELL-ACTIVATING PROPERTIES OF AN ANTI-THY-1 MONOCLONAL-ANTIBODY - POSSIBLE ANALOGY TO OKT3/LEU-4, JOURNAL OF EXPERIMENTAL MEDICINE 159: 716 (1984). (10.1084/jem.159.3.716) / JOURNAL OF EXPERIMENTAL MEDICINE (1984)
HIGUCHI, R, A GENERAL-METHOD OF INVITRO PREPARATION AND SPECIFIC MUTAGENESIS OF DNA FRAGMENTS - STUDY OF PROTEIN AND DNA INTERACTIONS, NUCLEIC ACIDS RESEARCH 16: 7351 (1988). (10.1093/nar/16.15.7351) / NUCLEIC ACIDS RESEARCH (1988)
HSI, E.D., T-CELL ACTIVATION INDUCES RAPID TYROSINE PHOSPHORYLATION OF A LIMITED NUMBER OF CELLULAR SUBSTRATES, JOURNAL OF BIOLOGICAL CHEMISTRY 264: 10836 (1989). (10.1016/S0021-9258(18)81696-9) / JOURNAL OF BIOLOGICAL CHEMISTRY (1989)
IRVING, B.A., THE CYTOPLASMIC DOMAIN OF THE T-CELL RECEPTOR ZETA-CHAIN IS SUFFICIENT TO COUPLE TO RECEPTOR-ASSOCIATED SIGNAL TRANSDUCTION PATHWAYS, CELL 64: 891 (1991). (10.1016/0092-8674(91)90314-O) / CELL (1991)
JUNE, C.H., INCREASES IN TYROSINE PHOSPHORYLATION ARE DETECTABLE BEFORE PHOSPHOLIPASE-C ACTIVATION AFTER T-CELL RECEPTOR STIMULATION, JOURNAL OF IMMUNOLOGY 144: 1591 (1990). (10.4049/jimmunol.144.5.1591) / JOURNAL OF IMMUNOLOGY (1990)
KLAUSNER, R.D., T-CELL ANTIGEN RECEPTOR ACTIVATION PATHWAYS - THE TYROSINE KINASE CONNECTION, CELL 64: 875 (1991). (10.1016/0092-8674(91)90310-U) / CELL (1991)
KONING, F, THE IMPLICATIONS OF SUBUNIT INTERACTIONS FOR THE STRUCTURE OF THE T-CELL RECEPTOR-CD3 COMPLEX, EUROPEAN JOURNAL OF IMMUNOLOGY 20: 299 (1990). (10.1002/eji.1830200211) / EUROPEAN JOURNAL OF IMMUNOLOGY (1990)
10.1073/pnas.84.5.1374
LETOURNEUR, F, T-CELL AND BASOPHIL ACTIVATION THROUGH THE CYTOPLASMIC TAIL OF T-CELL-RECEPTOR ZETA-FAMILY PROTEINS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88: 8905 (1991). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1991)
LETOURNEUR F unpublished data.
MANOLIOS, N, PAIRWISE, COOPERATIVE AND INHIBITORY INTERACTIONS DESCRIBE THE ASSEMBLY AND PROBABLE STRUCTURE OF THE T-CELL ANTIGEN RECEPTOR, EMBO JOURNAL 10: 1643 (1991). (10.1002/j.1460-2075.1991.tb07687.x) / EMBO JOURNAL (1991)
10.1038/338383b0
ROMEO, C, CELLULAR-IMMUNITY TO HIV ACTIVATED BY CD4 FUSED TO T-CELL OR FC RECEPTOR POLYPEPTIDES, CELL 64: 1037 (1991). (10.1016/0092-8674(91)90327-U) / CELL (1991)
RUBIN, L.A., A MONOCLONAL-ANTIBODY 7G7/B6, BINDS TO AN EPITOPE ON THE HUMAN INTERLEUKIN-2 (IL-2) RECEPTOR THAT IS DISTINCT FROM THAT RECOGNIZED BY IL-2 OR ANTI-TAC, HYBRIDOMA 4: 91 (1985). (10.1089/hyb.1985.4.91) / HYBRIDOMA (1985)
SAMELSON, L.E., IDENTIFICATION OF THE COMPONENTS OF THE MURINE T-CELL ANTIGEN RECEPTOR COMPLEX, CELL 43: 223 (1985). (10.1016/0092-8674(85)90027-3) / CELL (1985)
SAMELSON, L.E., ASSOCIATION OF THE FYN PROTEIN-TYROSINE KINASE WITH THE T-CELL ANTIGEN RECEPTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 4358 (1990). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1990)
SCHWARTZ, R.H., LYMPHOCYTE-T RECOGNITION OF ANTIGEN IN ASSOCIATION WITH GENE-PRODUCTS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX, ANNUAL REVIEW OF IMMUNOLOGY 3: 237 (1985). (10.1146/annurev.iy.03.040185.001321) / ANNUAL REVIEW OF IMMUNOLOGY (1985)
Seldin, R. F., Current Protocols in Molecular Biology 1: 921 (1990). / Current Protocols in Molecular Biology (1990)
SUSSMAN, J.J., FAILURE TO SYNTHESIZE THE T-CELL CD3-ZETA CHAIN - STRUCTURE AND FUNCTION OF A PARTIAL T-CELL RECEPTOR COMPLEX, CELL 52: 85 (1988). (10.1016/0092-8674(88)90533-8) / CELL (1988)
TAKEBE, Y, SR-ALPHA PROMOTER - AN EFFICIENT AND VERSATILE MAMMALIAN CDNA EXPRESSION SYSTEM COMPOSED OF THE SIMIAN VIRUS-40 EARLY PROMOTER AND THE R-U5 SEGMENT OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-1 LONG TERMINAL REPEAT, MOLECULAR AND CELLULAR BIOLOGY 8: 466 (1988). / MOLECULAR AND CELLULAR BIOLOGY (1988)
WHITE, J, 2 BETTER CELL-LINES FOR MAKING HYBRIDOMAS EXPRESSING SPECIFIC T-CELL RECEPTORS, JOURNAL OF IMMUNOLOGY 143: 1822 (1989). (10.4049/jimmunol.143.6.1822) / JOURNAL OF IMMUNOLOGY (1989)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:03 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 4:31 a.m.)
Indexed	3 months, 4 weeks ago (April 24, 2025, 1:47 a.m.)
Issued	33 years, 7 months ago (Jan. 3, 1992)
Published	33 years, 7 months ago (Jan. 3, 1992)
Published Print	33 years, 7 months ago (Jan. 3, 1992)

Funders 0

None

BibTeX

@article{Letourneur_1992, title={Activation of T Cells by a Tyrosine Kinase Activation Domain in the Cytoplasmic Tail of CD3 ε}, volume={255}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1532456}, DOI={10.1126/science.1532456}, number={5040}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Letourneur, François and Klausner, Richard D.}, year={1992}, month=jan, pages={79–82} }

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