DOI: 10.1126/science.1531159. Protection of Macaques Against SIV Infection by Subunit Vaccines of SIV Envelope Glycoprotein gp160

Protection of Macaques Against SIV Infection by Subunit Vaccines of SIV Envelope Glycoprotein gp160

10.1126/science.1531159

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Simian immunodeficiency virus (SIV) is a primate lentivirus related to human immunodeficiency viruses and is an etiologic agent for acquired immunodeficiency syndrome (AIDS)-like diseases in macaques. To date, only inactivated whole virus vaccines have been shown to protect macaques against SIV infection. Protective immunity was elicited by recombinant subunit vaccines. Four Macaca fascicularis were immunized with recombinant vaccinia virus expressing SIV mne gp160 and were boosted with gp160 produced in baculovirus-infected cells. All four animals were protected against an intravenous challenge of the homologous virus at one to nine animal-infectious doses. These results indicate that immunization with viral envelope antigens alone is sufficient to elicit protective immunity against a primate immunodeficiency virus. The combination immunization regimen, similar to one now being evaluated in humans as candidate human immunodeficiency virus (HIV)-1 vaccines, appears to be an effective way to elicit such immune responses.

Bibliography

Hu, S.-L., Abrams, K., Barber, G. N., Moran, P., Zarling, J. M., Langlois, A. J., Kuller, L., Morton, W. R., & Benveniste, R. E. (1992). Protection of Macaques Against SIV Infection by Subunit Vaccines of SIV Envelope Glycoprotein gp160. Science, 255(5043), 456â459.

Authors 9

Shuu-Lok Hu (first)
Kraig Abrams (additional)
Glen N. Barber (additional)
Patricia Moran (additional)
Joyce M. Zarling (additional)
Alphonse J. Langlois (additional)
LaRene Kuller (additional)
William R. Morton (additional)
Raoul E. Benveniste (additional)

References 32 Referenced 267

BARBER G.N. unpublished data.
BENVENISTE, R.E., MOLECULAR CHARACTERIZATION AND COMPARISON OF SIMIAN IMMUNODEFICIENCY VIRUS ISOLATES FROM MACAQUES, MANGABEYS, AND AFRICAN-GREEN MONKEYS, JOURNAL OF MEDICAL PRIMATOLOGY 18: 287 (1989). (10.1111/j.1600-0684.1989.tb00231.x) / JOURNAL OF MEDICAL PRIMATOLOGY (1989)
BENVENISTE, R.E., CHARACTERIZATION OF CLONES OF HIV-1 INFECTED HUT-78 CELLS DEFECTIVE IN GAG GENE PROCESSING AND OF SIV CLONES PRODUCING LARGE AMOUNTS OF ENVELOPE GLYCOPROTEIN, JOURNAL OF MEDICAL PRIMATOLOGY 19: 351 (1990). (10.1111/j.1600-0684.1990.tb00441.x) / JOURNAL OF MEDICAL PRIMATOLOGY (1990)
10.1128/jvi.60.2.483-490.1986
10.1128/jvi.62.6.2091-2101.1988
BENVENISTE R.E. unpublished data.
10.1038/345622a0
CARLSON, J.R., VACCINE PROTECTION OF RHESUS MACAQUES AGAINST SIMIAN IMMUNODEFICIENCY VIRUS-INFECTION, AIDS RESEARCH AND HUMAN RETROVIRUSES 6: 1239 (1990). (10.1089/aid.1990.6.1239) / AIDS RESEARCH AND HUMAN RETROVIRUSES (1990)
CHIN, J, PROJECTIONS OF HIV INFECTIONS AND AIDS CASES TO THE YEAR 2000, BULLETIN OF THE WORLD HEALTH ORGANIZATION 68: 1 (1990). / BULLETIN OF THE WORLD HEALTH ORGANIZATION (1990)
10.1016/0140-6736(91)91636-9
Cooney E. L. abstract Th.A.33 Sixth International Conference on AIDS San Francisco CA 20 to 24 June (1990).
Cranage M. P. Science 153 in press.
DESROSIERS, R.C., VACCINE PROTECTION AGAINST SIMIAN IMMUNODEFICIENCY VIRUS-INFECTION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 86: 6353 (1989). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1989)
Gardner, M. B., AIDS 5: 115 (1991). / AIDS (1991)
Graham B. S. abstract F.A.1 Seventh International Conference on AIDS Florence Italy 16 to 21 June (1991).
HENDERSON, L.E., ISOLATION AND CHARACTERIZATION OF A NOVEL PROTEIN (X-ORF PRODUCT) FROM SIV AND HIV-2, SCIENCE 241: 199 (1988). (10.1126/science.3388031) / SCIENCE (1988)
HU, S.L., NEUTRALIZING ANTIBODIES AGAINST HIV-1 BRU AND SF2 ISOLATES GENERATED IN MICE IMMUNIZED WITH RECOMBINANT VACCINIA VIRUS EXPRESSING HIV-1 (BRU) ENVELOPE GLYCOPROTEINS AND BOOSTED WITH HOMOLOGOUS GP160, AIDS RESEARCH AND HUMAN RETROVIRUSES 7: 615 (1991). (10.1089/aid.1991.7.615) / AIDS RESEARCH AND HUMAN RETROVIRUSES (1991)
Hu, S. L., AIDS Research and Human Retroviruses 7: 615 (1991). (10.1089/aid.1991.7.615) / AIDS Research and Human Retroviruses (1991)
Hu S. L. Journal of Medical Primatology in press.
HU, S.L., EXPRESSION OF ENVELOPE GLYCOPROTEINS OF HUMAN-IMMUNODEFICIENCY-VIRUS BY AN INSECT VIRUS VECTOR, JOURNAL OF VIROLOGY 61: 3617 (1987). (10.1128/jvi.61.11.3617-3620.1987) / JOURNAL OF VIROLOGY (1987)
HU, S.L., CHARACTERIZATION OF A RECOMBINANT VACCINIA VIRUS EXPRESSING HUMAN MELANOMA-ASSOCIATED ANTIGEN-P97, JOURNAL OF VIROLOGY 62: 176 (1988). (10.1128/jvi.62.1.176-180.1988) / JOURNAL OF VIROLOGY (1988)
HU, S.L., EXPRESSION OF AIDS VIRUS ENVELOPE GENE IN RECOMBINANT VACCINIA VIRUSES, NATURE 320: 537 (1986). (10.1038/320537a0) / NATURE (1986)
KOFF, W.C., AIDS 4 1: 179 (1990). (10.1097/00002030-199001001-00027) / AIDS (1990)
KULLER L unpublished data.
LANGLOIS, A.J., INVITRO ASSAYS FOR DETECTING NEUTRALIZING AND FUSION-INHIBITING ANTIBODIES TO SIVMAC251, AIDS RESEARCH AND HUMAN RETROVIRUSES 7: 713 (1991). (10.1089/aid.1991.7.713) / AIDS RESEARCH AND HUMAN RETROVIRUSES (1991)
10.1126/science.1549775
LUCKOW, V.A., BIO-TECHNOLOGY 6: 47 (1988). / BIO-TECHNOLOGY (1988)
MURPHEYCORB, M, EFFICACY OF SIV/DELTAB670 GLYCOPROTEIN-ENRICHED AND GLYCOPROTEIN-DEPLETED SUBUNIT VACCINES IN PROTECTING AGAINST INFECTION AND DISEASE IN RHESUS-MONKEYS, AIDS 5: 655 (1991). (10.1097/00002030-199106000-00003) / AIDS (1991)
10.1126/science.2555923
Murphey-Corb M. abstract Third Annual Meeting of the National Cooperative Vaccine Development Groups Clearwater FL 1 to 5 October (1990).
SHAFFERMAN, A, PROTECTION OF MACAQUES WITH A SIMIAN IMMUNODEFICIENCY VIRUS ENVELOPE PEPTIDE VACCINE BASED ON CONSERVED HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SEQUENCES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 88: 7126 (1991). / PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (1991)
STOTT, E.J., ANTI-CELL ANTIBODY IN MACAQUES, NATURE 353: 393 (1991). / NATURE (1991)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:03 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 4:24 a.m.)
Indexed	1 day, 20 hours ago (Aug. 21, 2025, 12:31 p.m.)
Issued	33 years, 6 months ago (Jan. 24, 1992)
Published	33 years, 6 months ago (Jan. 24, 1992)
Published Print	33 years, 6 months ago (Jan. 24, 1992)

Funders 0

None

BibTeX

@article{Hu_1992, title={Protection of Macaques Against SIV Infection by Subunit Vaccines of SIV Envelope Glycoprotein gp160}, volume={255}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1531159}, DOI={10.1126/science.1531159}, number={5043}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Hu, Shuu-Lok and Abrams, Kraig and Barber, Glen N. and Moran, Patricia and Zarling, Joyce M. and Langlois, Alphonse J. and Kuller, LaRene and Morton, William R. and Benveniste, Raoul E.}, year={1992}, month=jan, pages={456–459} }

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  ],
  "URL": "http://dx.doi.org/10.1126/science.1531159",
  "relation": {},
  "ISSN": [
    "0036-8075",
    "1095-9203"
  ],
  "subject": [],
  "container-title-short": "Science",
  "published": {
    "date-parts": [
      [
        1992,
        1,
        24
      ]
    ]
  }
}