DOI: 10.1126/science.1529341. A 90-Kilodalton Endothelial Cell Molecule Mediating Lymphocyte Binding in Humans

A 90-Kilodalton Endothelial Cell Molecule Mediating Lymphocyte Binding in Humans

10.1126/science.1529341

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Interactions between leukocyte surface receptors and their ligands on vascular endothelial cells control lymphocyte traffic between the blood and various lymphoid organs, as well as extravasation of leukocytes into sites of inflammation. A heretofore undescribed 90-kilodalton human endothelial cell adhesion molecule (VAP-1) defined by a monoclonal antibody 1B2 is described. The expression pattern, molecular mass, functional properties, and an amino-terminal amino acid sequence define VAP-1 as an endothelial ligand for lymphocytes. VAP-1 helps to elucidate the complex heterotypic cell interactions that direct tissue-selective lymphocyte migration in man.

Bibliography

Salmi, M., & Jalkanen, S. (1992). A 90-Kilodalton Endothelial Cell Molecule Mediating Lymphocyte Binding in Humans. Science, 257(5075), 1407â1409.

Authors 2

Marko Salmi (first)
Sirpa Jalkanen (additional)

References 24 Referenced 246

BERG, E.L., THE HUMAN PERIPHERAL LYMPH-NODE VASCULAR ADDRESSIN IS A LIGAND FOR LECAM-1, THE PERIPHERAL LYMPH-NODE HOMING RECEPTOR, JOURNAL OF CELL BIOLOGY 114: 343 (1991). (10.1083/jcb.114.2.343) / JOURNAL OF CELL BIOLOGY (1991)
10.1073/pnas.84.24.9238
BUTCHER, E.C., LEUKOCYTE-ENDOTHELIAL CELL RECOGNITION - 3 (OR MORE) STEPS TO SPECIFICITY AND DIVERSITY, CELL 67: 1033 (1991). (10.1016/0092-8674(91)90279-8) / CELL (1991)
BUTCHER, E.C., THE REGULATION OF LYMPHOCYTE TRAFFIC, CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY 128: 85 (1986). (10.1007/978-3-642-71272-2_3) / CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY (1986)
BUTCHER, E.C., EUR J IMMUNOL 10: 210 (1980). (10.1002/eji.1830100310) / EUR J IMMUNOL (1980)
10.1084/jem.164.2.661
DEFOUGEROLLES, A.R., CHARACTERIZATION OF ICAM-2 AND EVIDENCE FOR A 3RD COUNTER-RECEPTOR FOR LFA-1, JOURNAL OF EXPERIMENTAL MEDICINE 174: 253 (1991). (10.1084/jem.174.1.253) / JOURNAL OF EXPERIMENTAL MEDICINE (1991)
DUSTIN, M.L., INDUCTION BY IL-1 AND INTERFERON-GAMMA - TISSUE DISTRIBUTION, BIOCHEMISTRY, AND FUNCTION OF A NATURAL ADHERENCE MOLECULE (ICAM-1), JOURNAL OF IMMUNOLOGY 137: 245 (1986). (10.4049/jimmunol.137.1.245) / JOURNAL OF IMMUNOLOGY (1986)
HATTORI, R, STIMULATED SECRETION OF ENDOTHELIAL VONWILLEBRAND-FACTOR IS ACCOMPANIED BY RAPID REDISTRIBUTION TO THE CELL-SURFACE OF THE INTRACELLULAR GRANULE MEMBRANE-PROTEIN GMP-140, JOURNAL OF BIOLOGICAL CHEMISTRY 264: 7768 (1989). (10.1016/S0021-9258(18)83104-0) / JOURNAL OF BIOLOGICAL CHEMISTRY (1989)
10.1126/science.3726548
JALKANEN, S.T., INVITRO ANALYSIS OF THE HOMING PROPERTIES OF HUMAN-LYMPHOCYTES - DEVELOPMENTAL REGULATION OF FUNCTIONAL RECEPTORS FOR HIGH ENDOTHELIAL VENULES, BLOOD 66: 577 (1985). (10.1182/blood.V66.3.577.577) / BLOOD (1985)
MCEVER, R.P., GMP-140, A PLATELET ALPHA-GRANULE MEMBRANE-PROTEIN, IS ALSO SYNTHESIZED BY VASCULAR ENDOTHELIAL-CELLS AND IS LOCALIZED IN WEIBEL-PALADE BODIES, JOURNAL OF CLINICAL INVESTIGATION 84: 92 (1989). (10.1172/JCI114175) / JOURNAL OF CLINICAL INVESTIGATION (1989)
10.1016/0092-8674(89)90775-7
OSBORN, L, LEUKOCYTE ADHESION TO ENDOTHELIUM IN INFLAMMATION, CELL 62: 3 (1990). (10.1016/0092-8674(90)90230-C) / CELL (1990)
PICKER, L.J., ELAM-1 IS AN ADHESION MOLECULE FOR SKIN-HOMING T-CELLS, NATURE 349: 796 (1991). (10.1038/349796a0) / NATURE (1991)
POBER, J.S., OVERLAPPING PATTERNS OF ACTIVATION OF HUMAN-ENDOTHELIAL CELLS BY INTERLEUKIN-1, TUMOR-NECROSIS-FACTOR, AND IMMUNE INTERFERON, JOURNAL OF IMMUNOLOGY 137: 1893 (1986). (10.4049/jimmunol.137.6.1893) / JOURNAL OF IMMUNOLOGY (1986)
POBER, J.S., THE ROLE OF ENDOTHELIAL-CELLS IN INFLAMMATION, TRANSPLANTATION 50: 537 (1990). (10.1097/00007890-199010000-00001) / TRANSPLANTATION (1990)
RICE, G.E., VASCULAR AND NONVASCULAR EXPRESSION OF INCAM-110 - A TARGET FOR MONONUCLEAR LEUKOCYTE ADHESION IN NORMAL AND INFLAMED HUMAN TISSUES, AMERICAN JOURNAL OF PATHOLOGY 138: 385 (1991). / AMERICAN JOURNAL OF PATHOLOGY (1991)
10.1084/jem.171.4.1369
SALMI M unpublished data.
SHIMIZU, S, IMMUNOL TODAY 13: 106 (1992). (10.1016/0167-5699(92)90151-V) / IMMUNOL TODAY (1992)
10.1038/346425a0
STOOLMAN, L.M., ADHESION MOLECULES CONTROLLING LYMPHOCYTE MIGRATION, CELL 56: 907 (1989). (10.1016/0092-8674(89)90620-X) / CELL (1989)
WELLICOME, S.M., A MONOCLONAL-ANTIBODY THAT DETECTS A NOVEL ANTIGEN ON ENDOTHELIAL-CELLS THAT IS INDUCED BY TUMOR-NECROSIS-FACTOR, IL-1, OR LIPOPOLYSACCHARIDE, JOURNAL OF IMMUNOLOGY 144: 2558 (1990). (10.4049/jimmunol.144.7.2558) / JOURNAL OF IMMUNOLOGY (1990)

Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:03 p.m.)
Deposited	1 year, 7 months ago (Jan. 11, 2024, 5:27 a.m.)
Indexed	1 week, 3 days ago (Aug. 22, 2025, 12:47 a.m.)
Issued	32 years, 11 months ago (Sept. 4, 1992)
Published	32 years, 11 months ago (Sept. 4, 1992)
Published Print	32 years, 11 months ago (Sept. 4, 1992)

Funders 0

None

BibTeX

@article{Salmi_1992, title={A 90-Kilodalton Endothelial Cell Molecule Mediating Lymphocyte Binding in Humans}, volume={257}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1529341}, DOI={10.1126/science.1529341}, number={5075}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Salmi, Marko and Jalkanen, Sirpa}, year={1992}, month=sep, pages={1407–1409} }

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