DOI: 10.1126/science.1470916. Cellular Proteins Bound to Immunodeficiency Viruses: Implications for Pathogenesis and Vaccines

Cellular Proteins Bound to Immunodeficiency Viruses: Implications for Pathogenesis and Vaccines

10.1126/science.1470916

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

Cellular proteins associated with immunodeficiency viruses were identified by determination of the amino acid sequence of the proteins and peptides present in sucrose density gradient-purified human immunodeficiency virus (HIV)-1, HIV-2, and simian immunodeficiency virus (SIV). β2 microglobulin (β 2 m) and the α and β chains of human lymphocyte antigen (HLA) DR were present in virus preparations at one-fifth the concentration of Gag on a molar basis. Antisera to HLA DR, β 2 m, as well as HLA class I precipitated intact viral particles, suggesting that these cellular proteins were physically associated with the surface of the virus. Antisera to class I, β 2 m, and HLA DR also inhibited infection of cultured cells by both HIV-1 and SIV. The specific, selective association of these cellular proteins in a physiologically relevant manner has major implications for our understanding of the infection process and the pathogenesis of immunodeficiency viruses and should be considered in the design of vaccines.

Bibliography

Arthur, L. O., Bess, J. W., Sowder, R. C., Benveniste, R. E., Mann, D. L., Chermann, J.-C., & Henderson, L. E. (1992). Cellular Proteins Bound to Immunodeficiency Viruses: Implications for Pathogenesis and Vaccines. Science, 258(5090), 1935â1938.

Authors 7

Larry O. Arthur (first)
Julian W. Bess (additional)
Raymond C. Sowder (additional)
Raoul E. Benveniste (additional)
Dean L. Mann (additional)
Jean-Claude Chermann (additional)
Louis E. Henderson (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:03 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 9:52 p.m.)
Indexed	2 weeks, 2 days ago (Aug. 6, 2025, 8:01 a.m.)
Issued	32 years, 8 months ago (Dec. 18, 1992)
Published	32 years, 8 months ago (Dec. 18, 1992)
Published Print	32 years, 8 months ago (Dec. 18, 1992)

Funders 0

None

BibTeX

@article{Arthur_1992, title={Cellular Proteins Bound to Immunodeficiency Viruses: Implications for Pathogenesis and Vaccines}, volume={258}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1470916}, DOI={10.1126/science.1470916}, number={5090}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Arthur, Larry O. and Bess, Julian W. and Sowder, Raymond C. and Benveniste, Raoul E. and Mann, Dean L. and Chermann, Jean-Claude and Henderson, Louis E.}, year={1992}, month=dec, pages={1935–1938} }

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