DOI: 10.1126/science.1439838. Post-Transcriptional Regulation of Early T Cell Development by T Cell Receptor Signals

Post-Transcriptional Regulation of Early T Cell Development by T Cell Receptor Signals

10.1126/science.1439838

Crossref journal-article

American Association for the Advancement of Science (AAAS)

Science (221)

Abstract

During differentiation in the thymus, immature T cells progress through an ordered sequence of developmental stages that are best characterized by variable expression of the co-receptor molecules CD4 and CD8. Crosslinking of T cell receptor (TCR) molecules on precursor thymocytes was found to block their differentiation into CD4 + CD8 + cells by eliminating messenger RNA's encoding two families of developmentally important molecules: the co-receptor molecules CD4 and CD8 and the recombination activating genes 1 and 2. TCR-induced post-transcriptional regulation in early thymocytes was specific for selective messenger RNA's, required protein synthesis, and was itself developmentally regulated. These data identify a post-transcriptional mechanism that is influenced by TCR signals and that regulates early thymocyte development.

Bibliography

Takahama, Y., & Singer, A. (1992). Post-Transcriptional Regulation of Early T Cell Development by T Cell Receptor Signals. Science, 258(5087), 1456â1462.

Authors 2

Yousuke Takahama (first)
Alfred Singer (additional)

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Dates

Type	When
Created	18 years, 10 months ago (Oct. 5, 2006, 7:03 p.m.)
Deposited	1 year, 7 months ago (Jan. 10, 2024, 9:59 p.m.)
Indexed	5 months ago (March 31, 2025, 9:03 a.m.)
Issued	32 years, 9 months ago (Nov. 27, 1992)
Published	32 years, 9 months ago (Nov. 27, 1992)
Published Print	32 years, 9 months ago (Nov. 27, 1992)

Funders 0

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BibTeX

@article{Takahama_1992, title={Post-Transcriptional Regulation of Early T Cell Development by T Cell Receptor Signals}, volume={258}, ISSN={1095-9203}, url={http://dx.doi.org/10.1126/science.1439838}, DOI={10.1126/science.1439838}, number={5087}, journal={Science}, publisher={American Association for the Advancement of Science (AAAS)}, author={Takahama, Yousuke and Singer, Alfred}, year={1992}, month=nov, pages={1456–1462} }

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